Coronavirus Outbreak Explained: What Is Genome Sequencing And How Can It Help Combat COVID-19 Pandemic

Coronavirus Outbreak Explained: What Is Genome Sequencing And How Can It Help Combat COVID-19 Pandemic

According to experts, coronavirus has a tendency to mutate as they multiply which can have harmful, beneficial or no effects and so it is important to keep a track of the genome sequencing in order to check its virulence
Coronavirus Explainers, News
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Coronavirus Outbreak Explained: What Is Genome Sequencing And How Can It Help Combat COVID-19 PandemicScientists are scanning samples taken from #COVID19 infected people to look for mutations, through a process called genome sequencing. Experts explain why it is important in fighting the pandemic
  • Genome sequencing is similar to fingerprinting the DNA code of an organism
  • Viruses can mutate as these multiply after infecting a person: Experts
  • By sequencing virus samples, researchers can look for prevalent strain

New Delhi: After over a year, SARS-CoV-2, the virus behind the COVID-19 pandemic continues to multiply, mutate and spread. Since the outbreak, researchers across the world have found multiple variants of coronavirus that differ from the one found in Wuhan, China in December 2019 which is considered to be the ‘original’ strain. In order to identify and know about the new strains that coronavirus mutates into, scientists are scanning samples from infected persons through a process called ‘genome sequencing’. While this method has been used for years to study organisms like virus, bacteria, plants, animal and humans, NDTV spoke to experts to understand how it can help in combating the COVID-19 pandemic.

Also Read: COVID-19 Vaccine FAQs Answered BY WHO’s Chief Scientist Dr Soumya Swaminathan

What Is Genome Sequencing And How Does It Work?

According to Dr Chandrakant Lahariya, epidemiologist and public health specialist based in Delhi, genome is the complete genetic material of an organism. It is like an instruction manual which contains information about the make-up of the organism, he said. While human genomes are made of DNA (Deoxyribonucleic acid), a virus genome can be made of either DNA or RNA (Ribonucleic acid). DNA and RNA provide genetic instructions for growth and functioning of organisms. Coronavirus is made of RNA. Genome sequencing is a technique that reads and interprets genetic information found within DNA or RNA, said Dr Preeti Kumar, Vice President- Public Health System Support at the Public Health Foundation of India (PHFI).

Dr. Kumar further explained that genome sequencing or Whole Genome Sequencing (WGS) involves analysing the genetic code of an organism and is done with the help of powerful computers. While talking about the need for sequencing, she said,

As we know well that virus undergoes mutation, as they replicate. Mutation are tiny errors in the genetic code that occur during the duplication process. While some are harmless, others can bring about such changes in the virus that can make it more transmissible or deadly. So, it is important to keep a track of the genomic sequencing in order to check the virulence of the virus. As the number of differences between viral strains increase, it’s likely that the resulting viruses will also behave differently in terms of how fast it spreads, the kind of symptoms and the intensity of the disease it causes. The differences can be beneficial, harmful or inconsequential. Different variants can have different tendencies and may need new containment and treatment strategies.

Explaining the process of genome sequencing, Dr Rakesh Mishra, director of the Council of Scientific and Industrial Research- Centre for Cellular and Molecular Biology (CSIR- CCMB), Hyderabad said that after a sample in the form of the swab is tested positive through RT-PCR (Reverse transcription-polymerase chain reaction) test, it can be sent to sequencing labs. He further said that researchers break open the virus’s cells, isolate the genetic material in the form of RNA from it, convert it into DNA and analyse it using technology. The RNA of SARS-CoV-2 contains almost 30,000 molecules with distinct physical and chemical properties. So, by looking at these molecules, scientists can determine the sequence of the genome for that virus. Then, they compare the final sequence with that of previous strains to check whether it is a new or an existing strain.

According to Dr Lahariya, genome sequencing help scientists find the exact location in the virus where a mutation has taken place. If the mutation happens in significant proteins of the virus like the spike proteins which helps it to infect the human cell, then the virus is likely to spread at a faster speed, he said.

Also Read: Most People Are Naturally Armed Against COVID-19, Study Finds

How Can Genome Sequencing Help Fight The Pandemic?

By analysing differences in the genetic code of viruses from different patients, scientists aim to identify the transmission of the virus in real-time and see if different strains are emerging and which strains are more dominating in a particular country or area, said Dr Lahariya. He further explained that the information on the genetic makeup of the virus can help build strategies for public health and clinical care as well as devising containment measures.

According to Dr Lahariya, genome sequencing is useful for identifying hotspots or superspreaders (individuals who transmit the infection to a larger number of people than expected). This information provides insights to the policymakers for planning targeted public health interventions.

An understanding of the viral genomic sequence can assist researchers in designing treatments and vaccines that target specific function of the virus and also helps in preparing for further changes in the virus as it mutates and evolves, said Dr Lahariya.

According to the Global Initiative on Sharing All Influenza Data (GISAID), the open genome repository for viruses that cause influenza and COVID-19, there have been almost 5.25 lakh SARS-CoV-2 genomes sequence studies till February 12. Dr Lahariya said that while there is no set standard for optimal number of samples that should be sequenced, there is a need to ramp up sequencing in almost every country including India as much as possible. He said that currently, the United Kingdom has been leading the world’s sequencing which is roughly 5 per cent of the positive samples while India is doing way less than 1 per cent.

Also Read: Why Did South Africa Stop AstraZeneca COVID-19 Vaccine Rollout, An Expert Explains

Genomic Surveillance for Coronavirus (SARS-CoV-2) In India

India started sequencing genomes of COVID-19 positive samples in the beginning of the pandemic itself. According to the Ministry of Health and Family Welfare (MoHFW), in order to further enhance the genome surveillance, the Government of India formed Indian SARS-CoV-2 Genomics Consortium (INSACOG) in December 2020 for centralised genome surveillance of the novel coronavirus in the country. Coordinated by Department of Biotechnology (DBT) along with MoHFW, Indian Council of Medical Research (ICMR), and Council of Scientific and Industrial Research (CSIR), the consortium brings together 10 labs from around the country with a cumulative sequencing infrastructural capacity of more than 25,000 samples a month.

According to the Genome Evolution Analysis Resource for COVID-19 (GEAR-19), a dashboard built by CSIR- CCMB, India has submitted 5,898 genome sequences till date which is only 0.05 per cent of the total number of cases in the country. The INSACOG, according to Dr Mishra, aims to increase the sequencing to 5 per cent in the coming months. For this, it has asked the labs to ensure that genome sequences are coming from all parts of the country and samples from all the people arriving in India who test positive will be sent for genome sequencing to know about mutations.

The World Health Organsiation has urged countries to expand sequencing studies to address the unknown strains of coronavirus. It explained that coronavirus mutation first found in the United Kingdom had spread to over 50 countries while the one found in South Africa has spread in over 20 nations. Another strain, from Brazil, is being analysed and could impact immune response, WHO said. Dr Matshidiso Moeti, Regional Director for Africa, WHO said while addressing a press conference,

Even if the new variant is not more virulent, a virus that can spread more easily will put further strain on hospitals and health workers who are in many cases already overstretched. This is a stark reminder that the virus is relentless, that it still presents a manifest threat.

WHO asserted that more the virus spreads, higher are chances of mutations and new strains to come up, so it is important to vaccinate a critical mass of people to break the chain of transmission at soon as possible and till then it is essential to follow preventive measures like social distancing, hand hygiene, wearing masks and taking the vaccine to avoid infections.

Also Read: India’s Sero-Survey Findings: One In Five Indians Exposed To COVID-19, AIIMS Director Randeep Guleria Explains What It Means

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene


Coronavirus has spread to 193 countries. The total confirmed cases worldwide are 17,66,30,634 and 38,22,022 have died; 5,80,25,717 are active cases and 11,47,82,895 have recovered as on June 16, 2021 at 3:30 am.


2,96,33,105 62,224Cases
2,83,88,100 1,07,628Recovered
3,79,573 2,542Deaths
In India, there are 2,96,33,105 confirmed cases including 3,79,573 deaths. The number of active cases is 8,65,432 and 2,83,88,100 have recovered as on June 16, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths

59,24,773 7,652

1,41,440 8,982

56,69,179 15,176

1,14,154 1,458


27,77,010 5,041

1,62,303 9,859

25,81,559 14,785

33,148 115


27,48,204 12,246

1,12,792 1,456

26,23,904 13,536

11,508 166

Tamil Nadu

23,78,298 11,805

1,25,215 11,669

22,23,015 23,207

30,068 267

Andhra Pradesh

18,20,134 5,741

75,134 4,879

17,32,948 10,567

12,052 53

Uttar Pradesh

17,03,207 270

7,221 890

16,74,072 1,104

21,914 56

West Bengal

14,68,044 3,268

20,046 1,125

14,30,949 2,068

17,049 75


14,31,498 228

3,078 148

14,03,569 364

24,851 12


9,88,172 609

11,717 943

9,63,113 1,544

13,342 8


9,50,133 172

5,619 848

9,35,658 1,006

8,856 14


8,59,526 3,405

44,358 3,436

8,11,780 6,799

3,388 42


8,21,078 352

8,884 658

8,02,187 1,006

10,007 4

Madhya Pradesh

7,88,649 224

3,610 331

7,76,424 528

8,615 27


7,66,357 228

3,703 374

7,53,584 564

9,070 38


7,17,949 410

4,360 412

7,04,075 813

9,514 9


6,06,436 1,556

19,933 528

5,82,993 2,070

3,510 14


5,89,153 628

10,802 1,111

5,62,701 1,691

15,650 48


4,66,590 3,415

41,184 475

4,21,378 2,906

4,028 34


3,43,793 184

2,646 416

3,36,058 596

5,089 4


3,37,449 274

3,642 266

3,26,822 515

6,985 25

Jammu And Kashmir

3,08,726 715

12,407 1,125

2,92,114 1,830

4,205 10

Himachal Pradesh

1,99,197 321

4,050 382

1,91,737 691

3,410 12


1,63,048 327

4,175 231

1,55,926 548

2,947 10


1,13,192 355

4,668 279

1,06,828 629

1,696 5


61,200 40

486 21

59,917 58

797 3


61,096 785

8,744 301

51,354 476

998 8


60,385 536

4,886 65

54,870 596

629 5


42,759 450

4,430 99

37,579 542

750 7

Arunachal Pradesh

31,938 290

2,849 40

28,934 326

155 4


23,854 101

2,972 229

20,423 327

459 3


19,649 38

552 20

18,898 57

199 1


18,659 209

3,239 67

15,136 273

284 3


15,899 268

3,637 45

12,191 312

71 1

Dadra And Nagar Haveli

10,473 9

61 2

10,408 7



9,297 61

484 36

8,768 96

45 1

Andaman And Nicobar Islands

7,280 11

105 4

7,049 15


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