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One In Four People Experience Mild Side Effects From Covishield COVID-19 Vaccine: Lancet Study

The researchers from King’s College London in the UK found that most systemic side effects (meaning side effects excluding where the injection took place) of Covishield peaked within the first 24 hours following vaccination and usually lasted 1-2 days

One In Four People Experience Mild Side Effects From Covishield COVID-19 Vaccine: Lancet Study
Highlights
  • After effects of the vaccine are usually mild and short-lived: Researchers
  • The study analysed data of over six lakh people
  • Side effects were more common among people under 55 years: Study

New Delhi: One in four people experience mild, short lived systemic side effects after receiving either the COVID-19 preventive by Pfizer or AstraZeneca vaccine — known as Covishield in India — with headache, fatigue and tenderness the most common symptoms, according to a study published in the Lancet Infectious Diseases journal. The researchers from King’s College London in the UK also found that most systemic side effects — meaning side effects excluding where the injection took place — peaked within the first 24 hours following vaccination and usually lasted 1-2 days.

Also Read: The Good That People Do: Indians Reach Out With Helping Hand As COVID Spirals

The analysis of data from the ZOE COVID Symptom Study app found much fewer side effects in the general population with both the Pfizer and AstraZeneca vaccines than reported in trials. The study also reports a significant decrease of infection rates from 12 to 21 days after the first dose of the Pfizer (58 per cent reduction) and AstraZeneca (39 per cent reduction) vaccines compared to a control group.

The drop in infection at least 21 days after the first dose for Pfizer is 69 per cent and for AstraZeneca 60 per cent, according to the study. Systemic effects included headache, fatigue, chills and shiver, diarrhoea, fever, arthralgia, myalgia, and nausea. Local side effects — meaning side effects where the injection took place in the arm — included pain at the site of injection, swelling, tenderness, redness, itch, warmth and swollen armpit glands.

The data should reassure many people that in the real world, after effects of the vaccine are usually mild and short-lived, especially in the over 50’s who are most at risk of the infection, said Professor Tim Spector, lead scientist on the ZOE COVID Symptom Study app and Professor at King’s College London.

The data comes from 627,383 users of the ZOE COVID Symptom Study app who self-reported systemic and local effects within eight days of receiving one or two doses of the Pfizer vaccine or one dose of the AstraZeneca vaccine between December 8 and March 10.

Also Read: ‘Indian Strain’ Of Coronavirus Found In 17 Countries: WHO

The study also found that side effects were more common among people under 55 years of age and among women. Participants who had a confirmed case of prior COVID-19 were three times more likely to have side effects that affect the whole body after receiving doses of the Pfizer vaccine than those without known infection.

Those with a confirmed case of prior COVID-19 number were almost twice more likely to have side effects that affect the whole body after the first dose of the AstraZeneca vaccine. People with prior known COVID-19 infection were also more likely to experience local side effects, the researchers said.

The researchers noted that in Phase III clinical trials of the Pfizer vaccine, the most common side effects were pain at the injection site (71-83 per cent), fatigue (34-47 per cent) and headache (25-42 per cent). However, the real-world analysis found less than 30 per cent of users complained of injection site pain and less than 10 per cent of fatigue and headache after the first dose, they said.

Similarly, in Phase III trials for the AstraZeneca vaccine, systemic side effects were found in 88 per cent of younger participants (18-55 years) after the first dose but the study found a significantly lower rate of 46.2 per cent after the first dose.

Our results support the after effects safety of both vaccines with fewer side effects in the general population than reported in the Pfizer and AstraZeneca experimental trials and should help allay safety concerns of people willing to get vaccinated, Spector added.

Also Read: Single Vaccine Dose Cuts COVID-19 Transmission By Half: UK Study

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

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