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Pfizer Jab Side Effects In 12–15-Year-Olds At High Risk Of COVID-19 Complications, Mild To Moderate: Study

The UK’s vaccine advisory group, the Joint Committee on Vaccination and Immunisation (JCVI), advised that children aged 12 and over with severe neurological disabilities, who tend to get recurrent respiratory infections and have complex care needs, should be offered the COVID-19 jab

Pfizer Jab Side Effects In 12–15-Year-Olds At High Risk Of COVID-19 Complications, Mild To Moderate: Study
Highlights
  • Side effects of the vaccine in children were all mild to moderate: Study
  • All recorded side effects cleared up within a week: Study
  • The study aims to offer reassurance to parents and clinicians

London: A new study has revealed that the side effects of the Pfizer-BioNTech jab against COVID-19 in 12-15-year-olds at high risk of complications from the infection are likely to be mild to moderate and clear up quickly because of certain coexisting conditions. The findings of the study were published in the journal ‘Archives of Disease in Childhood’.

Also Read: What Are COVID-19 Breakthrough Infections? How Long Does Immunity Last After COVID-19 Vaccination? An Expert Explains

Although the study numbers are small, the data are representative of those teens most likely to benefit from the vaccination, and should offer reassurance to parents and clinicians, said the authors. Healthy children with COVID-19 infection generally have a mild illness, but some coexisting conditions, particularly neurological conditions, are associated with severe disease.

These high-risk children were therefore shielded to reduce their risk of infection, and wouldn’t have been included in early vaccine safety studies, said the authors. The UK’s vaccine advisory group, the Joint Committee on Vaccination and Immunisation (JCVI), advised that children aged 12 and over with severe neurological disabilities, who tend to get recurrent respiratory infections and have complex care needs, should be offered the COVID-19 jab.

Given the unknown side effects of vaccination in this complex and vulnerable group, the authors asked the parents of 27 of these children to record any side effects of subsequent COVID-19 vaccinations for each child.

The children were aged between 12 and 15; three were hospital inpatients; 16 were boys and most (21) were white. They had various neurological conditions, including muscular dystrophy and cerebral palsy, plus a range of coexisting medical conditions, such as epilepsy, congenital heart defects, and immune deficiency, for which they were receiving drug treatment of various kinds.

The reported side effects were all mild to moderate, except for one child who experienced severe fatigue and discomfort, combined with increased agitation. One family also reported that seizure type changed to clusters, although this had resolved a week later.

In all, there were 8 ‘events’ in 6 children after the first dose, all of which resolved within 72 hours: mild rash; headache; diarrhoea; presumed sore throat; neck pain; difficulty sleeping; and low blood glucose. After the second dose, 8 additional events occurred in 5 children: diarrhoea; vomiting; armpit swelling; and blisters around the mouth. Paracetamol use after the first dose was high and fever was more common than reported in studies of adults (13 per cent vs 4 per cent in 16-55-year-olds). But all recorded side effects cleared up within a week.

Numbers were small, but these data are especially important as they are representative of the children who are most likely to benefit from vaccination, and parents and clinicians may have concerns regarding an increased risk of unexpected events. The parents choosing to take up this vaccination at a time when it was off-licence, with little available safety data, did so because they (and their clinicians) believed their children to be at high risk of COVID-19 disease. Indeed, many had been shielding and felt that vaccination would make a significant difference to their lives, noted the authors.

Also Read: Half Of Hospitalised Covid Patients Have Persisting Symptoms After A Year: Lancet Study

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

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World

22,95,44,435Cases
19,20,52,504Active
3,27,83,741Recovered
47,08,190Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 22,95,44,435 and 47,08,190 have died; 19,20,52,504 are active cases and 3,27,83,741 have recovered as on September 22, 2021 at 3:49 am.

India

3,35,31,498 26,964Cases
3,01,9897,586Active
3,27,83,741 34,167Recovered
4,45,768 383Deaths
In India, there are 3,35,31,498 confirmed cases including 4,45,768 deaths. The number of active cases is 3,01,989 and 3,27,83,741 have recovered as on September 22, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,27,629 3,131

44,269 960

63,44,744 4,021

1,38,616 70

Kerala

45,39,926 15,768

1,61,765 5,813

43,54,264 21,367

23,897 214

Karnataka

29,69,361 818

13,769 617

29,17,944 1,414

37,648 21

Tamil Nadu

26,48,688 1,647

16,993 9

25,96,316 1,619

35,379 19

Andhra Pradesh

20,40,708 1,179

13,905 483

20,12,714 1,651

14,089 11

Uttar Pradesh

17,09,693 13

194 0

16,86,612 13

22,887

West Bengal

15,62,710 537

7,741 69

15,36,291 592

18,678 14

Delhi

14,38,556 39

400 21

14,13,071 18

25,085

Odisha

10,21,216 462

4,844 103

10,08,226 560

8,146 5

Chhattisgarh

10,05,120 26

297 0

9,91,260 26

13,563

Rajasthan

9,54,275 12

99 8

9,45,222 4

8,954

Gujarat

8,25,751 14

133 0

8,15,536 14

10,082

Madhya Pradesh

7,92,410 8

90 6

7,81,803 14

10,517

Haryana

7,70,754 8

328 12

7,60,618 20

9,808

Bihar

7,25,907 6

60 9

7,16,188 15

9,659

Telangana

6,63,906 244

4,938 53

6,55,061 296

3,907 1

Punjab

6,01,359 36

304 3

5,84,554 37

16,501 2

Assam

5,98,864 441

5,081 97

5,87,970 338

5,813 6

Jharkhand

3,48,139 14

65 10

3,42,941 4

5,133

Uttarakhand

3,43,405 12

249 18

3,35,765 29

7,391 1

Jammu And Kashmir

3,28,214 145

1,450 11

3,22,345 154

4,419 2

Himachal Pradesh

2,17,403 263

1,715 99

2,12,033 162

3,655 2

Goa

1,75,690 107

886 76

1,71,507 29

3,297 2

Puducherry

1,25,618 101

922 55

1,22,864 46

1,832

Manipur

1,18,870 197

2,174 9

1,14,861 203

1,835 3

Tripura

83,956 51

353 7

82,794 44

809

Mizoram

82,815 1,355

15,363 223

67,184 1,127

268 5

Meghalaya

79,817 150

1,878 18

76,558 167

1,381 1

Chandigarh

65,195 7

44 3

64,333 4

818

Arunachal Pradesh

54,190 64

413 3

53,504 60

273 1

Sikkim

31,014 43

627 27

30,007 70

380

Nagaland

30,959 52

470 3

29,832 46

657 3

Ladakh

20,743 6

144 6

20,392

207

Dadra And Nagar Haveli

10,670

0 0

10,666

4

Lakshadweep

10,360 1

9 1

10,300

51

Andaman And Nicobar Islands

7,607 7

17 4

7,461 3

129

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