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Bharat Biotech’s Covaxin Effective Against Delta Plus Covid Variant: Study

According to a study conducted by the Indian Council of Medical Research-National Institute of Virology, Covaxin has shown less reduction in ‘neutralizing activity’ while comparing with Delta and Delta AY.1 (Delta plus) variants in those who are fully vaccinated with the vaccine

Bharat Biotech's Covaxin Effective Against Delta Plus Covid Variant: Study
Highlights
  • MoHFW designated the Delta Plus as a variant of concern on June 22
  • India has as many as 70 cases of Delta plus variant: MoHFW
  • Highly contagious Delta variant led to second wave in India: Expert

New Delhi: Bharat Biotech’s COVID-19 vaccine Covaxin has shown less reduction in ‘neutralizing activity’ while comparing with Delta and Delta AY.1 (Delta plus) variants in those who are fully vaccinated with the vaccine according to a study by the Indian Council of Medical Research-National Institute of Virology (NIV). This means that people vaccinated with Covaxin will be protected against the current variants Delta, Delta AY.1 and B.1.617.3.

Also Read: Explained: What Is A Breakthrough Infection And How To Prevent Catching COVID-19 After Getting Fully Vaccinated

The MoHFW on June 22 designated the ‘Delta Plus’ variant of the novel coronavirus, as a “variant of concern”. Currently, India has as many as 70 cases of Delta plus variant. According to the study,

A minor reduction was observed in the neutralizing antibody titer in COVID- 19 recovered cases full BBV152 vaccinated and post immunized infected cases compared to COVID-19 naive vaccinated individuals.

The study was conducted with samples collected from three groups. Group 1 samples were collected after two doses with a gap of 2.5 to 22 weeks,

Group 1, Sera of individuals vaccinated with two doses of COVAXIN [Female (n=24) and Male (n=18)] collected between 2.5 to 22 weeks after second dose.

After group 1, samples of those individuals were collected who had taken the second dose and recovered from Covid-19, “Group 2: COVID-19 recovered cases with two doses of COVAXIN [female (n=8); male (n=6)], collected 14-70 weeks after the second dose.” The last samples were collected from group 3, “Group 3: breakthrough cases post two-dose COVAXIN vaccinations [female (n=17); male (n=13)] collected between 2-18 weeks.”

Also Read: Entire Adult Population In India Will Be Vaccinated Against COVID-19 By December: Dr NK Arora, Head, Expert Panel On Immunisation

However, with the observed high titers, the sera of individuals belonging to all the aforementioned groups they would still neutralize the Delta, Delta AY.1 and B.1.617.3 variants effectively, said the study.

“The vaccine sera effectively neutralizes the Delta, Delta AY.1 and B.1.617.3 in spite of some reduction in titer, which means vaccination will protect against these variants,” Dr Pragya Yadav, head of the NIV’s Maximum Containment Facility told ANI “Sera of individuals who were fully immunized (with 2 doses) didn’t show significant reduction in the NAb titer against Delta, Delta AY.1 and B.1.617.3”, said Dr Samiran Panda, Head of epidemiology and infectious diseases.

NAb titer of sera of recovered cases with vaccinations and breakthrough cases were significantly high compared to those with two doses of vaccinations. According to Dr Samiran Panda, Immunization is key to protect from severity and deaths in the current situation and reduce the burden on healthcare system.

A significant increase in NAb titer was also observed among these two groups against Delta, Delta AY.1 and B.1.617.3 variants. This demonstrates the possible role of memory cells in immune boosting with post-infection or infection after immunization. The comparative analysis of all the groups revealed that the B.1.617.3 variant seems to be less susceptible to neutralization followed by Delta AY.1 and Delta variants compared to B.1, stated the study.

A recent study published by Hacisuleyman E, demonstrated a reduction in neutralization by 4 fold and 11 fold against Delta variant with the sera of healthy individuals vaccinated with two doses of ChAdOx1 and BNT162b2 vaccine respectively.

Also Read: India Administers Over 35 Crore Doses In 170 Days, Second Highest Globally, Says Union Health Ministry

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

22,95,44,435Cases
19,20,52,504Active
3,27,83,741Recovered
47,08,190Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 22,95,44,435 and 47,08,190 have died; 19,20,52,504 are active cases and 3,27,83,741 have recovered as on September 22, 2021 at 3:49 am.

India

3,35,31,498 26,964Cases
3,01,9897,586Active
3,27,83,741 34,167Recovered
4,45,768 383Deaths
In India, there are 3,35,31,498 confirmed cases including 4,45,768 deaths. The number of active cases is 3,01,989 and 3,27,83,741 have recovered as on September 22, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,27,629 3,131

44,269 960

63,44,744 4,021

1,38,616 70

Kerala

45,39,926 15,768

1,61,765 5,813

43,54,264 21,367

23,897 214

Karnataka

29,69,361 818

13,769 617

29,17,944 1,414

37,648 21

Tamil Nadu

26,48,688 1,647

16,993 9

25,96,316 1,619

35,379 19

Andhra Pradesh

20,40,708 1,179

13,905 483

20,12,714 1,651

14,089 11

Uttar Pradesh

17,09,693 13

194 0

16,86,612 13

22,887

West Bengal

15,62,710 537

7,741 69

15,36,291 592

18,678 14

Delhi

14,38,556 39

400 21

14,13,071 18

25,085

Odisha

10,21,216 462

4,844 103

10,08,226 560

8,146 5

Chhattisgarh

10,05,120 26

297 0

9,91,260 26

13,563

Rajasthan

9,54,275 12

99 8

9,45,222 4

8,954

Gujarat

8,25,751 14

133 0

8,15,536 14

10,082

Madhya Pradesh

7,92,410 8

90 6

7,81,803 14

10,517

Haryana

7,70,754 8

328 12

7,60,618 20

9,808

Bihar

7,25,907 6

60 9

7,16,188 15

9,659

Telangana

6,63,906 244

4,938 53

6,55,061 296

3,907 1

Punjab

6,01,359 36

304 3

5,84,554 37

16,501 2

Assam

5,98,864 441

5,081 97

5,87,970 338

5,813 6

Jharkhand

3,48,139 14

65 10

3,42,941 4

5,133

Uttarakhand

3,43,405 12

249 18

3,35,765 29

7,391 1

Jammu And Kashmir

3,28,214 145

1,450 11

3,22,345 154

4,419 2

Himachal Pradesh

2,17,403 263

1,715 99

2,12,033 162

3,655 2

Goa

1,75,690 107

886 76

1,71,507 29

3,297 2

Puducherry

1,25,618 101

922 55

1,22,864 46

1,832

Manipur

1,18,870 197

2,174 9

1,14,861 203

1,835 3

Tripura

83,956 51

353 7

82,794 44

809

Mizoram

82,815 1,355

15,363 223

67,184 1,127

268 5

Meghalaya

79,817 150

1,878 18

76,558 167

1,381 1

Chandigarh

65,195 7

44 3

64,333 4

818

Arunachal Pradesh

54,190 64

413 3

53,504 60

273 1

Sikkim

31,014 43

627 27

30,007 70

380

Nagaland

30,959 52

470 3

29,832 46

657 3

Ladakh

20,743 6

144 6

20,392

207

Dadra And Nagar Haveli

10,670

0 0

10,666

4

Lakshadweep

10,360 1

9 1

10,300

51

Andaman And Nicobar Islands

7,607 7

17 4

7,461 3

129

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