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Researchers Found New Method To Detect COVID-19 In Less Than Five Minutes

The researchers of University of Illinois Grainger College of Engineering have developed a rapid, ultrasensitive test using a paper-based electrochemical sensor that can detect the presence of the SARS-CoV-2 in less than five minutes

Researchers Found New Method To Detect COVID-19 In Less Than Five Minutes
Highlights
  • Researchers have used graphene based biosensors to detect COVID-19 disease
  • Graphene-based biosensors have high sensitivity & rapid detection ability
  • The new technology also has a low cost of production

Illinois: The researchers of University of Illinois Grainger College of Engineering claimed to have developed an ultrasensitive test using a paper-based electrochemical sensor which is capable of detecting the presence of the coronavirus in mere five minutes. As the COVID-19 pandemic continues to spread across the world, the researchers from various laboratories have been coming up with the different strategies that can help to track the virus. The new study shows the possibility of detecting the virus through a rapid method with the use of a graphene biosensor which is adaptable to other viruses.

Also Read: New COVID-19 Testing Approach Measures Patients’ Immune Response For Better Diagnosis

A team led by professor Dipanjan Pan reported their findings in ACS Nano which shows that a bioengineering graduate student, Maha Alafeef from the University of Illinois Grainger has co-developed a rapid, ultrasensitive test using a paper-based electrochemical sensor that can detect the presence of the virus in less than five minutes.

Currently, we are experiencing a once-in-a-century life-changing event. We are responding to this global need from a holistic approach by developing multidisciplinary tools for early detection and diagnosis and treatment for SARS-CoV-2, said Maha Alafeef.

Also Read: New Smartphone-Based COVID-19 Test Gives Results In Less Than 30 Minutes

The two broad categories of COVID-19 tests in the market either use reverse transcriptase real-time polymerase chain reaction (RT-PCR) and nucleic acid hybridization strategies to identify viral RNA, or focuses on the detection of antibodies. However, there could be a delay of a few days to a few weeks after a person has been exposed to the virus for them to produce detectable antibodies.

In recent years, researchers have had some success with creating point-of-care biosensors using 2D nanomaterials such as graphene to detect diseases. The main advantages of graphene-based biosensors are their sensitivity, low cost of production and rapid detection turnaround.

Also Read: Rapid Testing Can Eliminate Spread Of COVID-19 Within Weeks, Says A Study

The discovery of graphene opened up a new era of sensor development due to its properties. Graphene exhibits unique mechanical and electrochemical properties that make it ideal for the development of sensitive electrochemical sensors, said Maha Alafeef.

There are two components to this biosensor, according to the study which is: a platform to measure an electrical read-out and probes to detect the presence of viral RNA. To create the platform, researchers first coated filter paper with a layer of graphene nanoplatelets to create a conductive film. Then, they placed a gold electrode with a predefined design on top of the graphene as a contact pad for electrical readout. Both gold and graphene have high sensitivity and conductivity which makes this platform ultrasensitive to detect changes in electrical signals.

Also Read: ICMR Nods For Centre For Cellular And Molecular Biology’s Dry Swab Testing For COVID-19

Current RNA-based COVID-19 tests screen for the presence of the N-gene (nucleocapsid phosphoprotein) on the SARS-CoV-2 virus. In this research, the team designed antisense oligonucleotide (ASOs) probes to target two regions of the N-gene. Targeting two regions ensures the reliability of the senor in case one region undergoes gene mutation. Furthermore, gold nanoparticles (AuNP) are capped with these single-stranded nucleic acids (ssDNA), which represents an ultra-sensitive sensing probe for the SARS-CoV-2 RNA.
The researchers showed that the hybridization of the viral RNA with these probes causes a change in the sensor electrical response.

The AuNP caps accelerate the electron transfer and when broadcasted over the sensing platform, results in an increase in the output signal and indicates the presence of the virus.

The team tested the performance of this sensor by using COVID-19 positive and negative samples. The sensor showed a significant increase in the voltage of positive samples compared to the negative ones and confirmed the presence of viral genetic material in less than five minutes. Furthermore, the sensor was able to differentiate viral RNA loads in these samples. “Viral load is an important quantitative indicator of the progress of infection and a challenge to measure using existing diagnostic methods”, stated the researchers.

Not only this, but this platform has far-reaching applications due to its portability and low cost. The sensor, when integrated with microcontrollers and LED screens or with a smartphone via Bluetooth or wifi, could be used at the point-of-care in a doctor’s office or even at home.

Also Read: COVID-19 Testing: Here’s All You Need To Know About Indigenously Developed Coronavirus Paper Strip Test ‘FELUDA’

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

23,96,06,768Cases
20,13,42,617Active
3,33,82,100Recovered
48,82,051Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 23,96,06,768 and 48,82,051 have died; 20,13,42,617 are active cases and 3,33,82,100 have recovered as on October 15, 2021 at 4:15 am.

India

3,40,37,592 16,862Cases
2,03,6782,908Active
3,33,82,100 19,391Recovered
4,51,814 379Deaths
In India, there are 3,40,37,592 confirmed cases including 4,51,814 deaths. The number of active cases is 2,03,678 and 3,33,82,100 have recovered as on October 15, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,86,280 2,384

33,157 6

64,13,418 2,343

1,39,705 35

Kerala

48,29,944 9,246

96,421 1,802

47,06,856 10,952

26,667 96

Karnataka

29,82,399 310

9,607 43

29,34,870 347

37,922 6

Tamil Nadu

26,83,396 1,259

15,451 199

26,32,092 1,438

35,853 20

Andhra Pradesh

20,59,122 540

6,588 27

20,38,248 557

14,286 10

Uttar Pradesh

17,10,008 12

135 4

16,86,976 16

22,897

West Bengal

15,79,012 530

7,576 81

15,52,491 601

18,945 10

Delhi

14,39,311 28

337 1

14,13,885 29

25,089

Odisha

10,33,809 521

4,890 38

10,20,645 477

8,274 6

Chhattisgarh

10,05,614 16

203 4

9,91,841 20

13,570

Rajasthan

9,54,382 8

42 6

9,45,386 2

8,954

Gujarat

8,26,244 34

215 20

8,15,943 14

10,086

Madhya Pradesh

7,92,669 12

111 1

7,82,035 11

10,523

Haryana

7,71,035 16

105 158

7,60,881

10,049 174

Bihar

7,26,016 8

42 6

7,16,313 2

9,661

Telangana

6,68,618 168

4,171 40

6,60,512 207

3,935 1

Assam

6,05,847 207

3,646 157

5,96,263 362

5,938 2

Punjab

6,01,971 33

234 11

5,85,199 16

16,538 6

Jharkhand

3,48,406 11

130 4

3,43,141 7

5,135

Uttarakhand

3,43,729 28

175 22

3,36,157 6

7,397

Jammu And Kashmir

3,30,834 93

935 11

3,25,473 104

4,426

Himachal Pradesh

2,21,113 182

1,387 5

2,16,011 173

3,715 4

Goa

1,77,356 68

679 27

1,73,342 39

3,335 2

Puducherry

1,27,259 49

647 4

1,24,763 53

1,849

Manipur

1,22,432 69

1,444 15

1,19,099 84

1,889

Mizoram

1,10,719 901

13,601 435

96,744 1,332

374 4

Tripura

84,295 4

110 8

83,369 12

816

Meghalaya

82,734 87

892 31

80,411 115

1,431 3

Chandigarh

65,295 10

32 5

64,443 15

820

Arunachal Pradesh

54,958 4

202 22

54,476 26

280

Sikkim

31,722 6

224 1

31,108 7

390

Nagaland

31,516 9

230 8

30,613 17

673

Ladakh

20,867 6

44 2

20,615 4

208

Dadra And Nagar Haveli

10,675

3 1

10,668 1

4

Lakshadweep

10,365

2 0

10,312

51

Andaman And Nicobar Islands

7,640 3

10 1

7,501 2

129

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