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Study Shows Downside Of Not Receiving Second Shot Of COVID-19 Vaccine

A team of scientists tested blood samples from adults who had tested positive for SARS-CoV-2 to measure how long the immunity benefits of Pfizer and Moderna vaccines last and how well they protect from newer variants

Study Shows Downside Of Not Receiving Second Shot Of COVID-19 Vaccine
Highlights
  • Prior exposure to COVID19 doesn’t guarantee high level of antibodies: Study
  • The study supports full vaccination even for COVID recovered patients
  • Blood samples full vaccination showed a very high level of antibodies

Washington: A new study has shown that two months after the second Pfizer/Moderna vaccination, antibody response decreases 20 per cent in adults with prior cases of COVID-19. The study also tested how well current vaccines resist emerging variants. The findings of the study were published in the journal ‘Scientific Reports’. The Northwestern University study underscored the importance of receiving a second dose of vaccine, not only because it is commonly known that immunity from vaccines wanes over time, but also because of the risk posed by emerging variants, including the highly contagious delta variant.

Also Read: New Variant (C.1.2) Of Coronavirus May Be More Infectious, Evade Vaccines: Study

The study also showed that prior exposure to SARS-CoV-2 does not guarantee a high level of antibodies, nor does it guarantee a robust antibody response to the first vaccine dose. This directly contradicts the assumption that contracting COVID will naturally make someone immune to re-infection. The findings further support vaccination (and two doses), even for people who have contracted the virus previously.

A team of scientists, including biological anthropologist Thomas McDade and pharmacologist Alexis Demonbreun, tested blood samples from adults who had tested positive for SARS-CoV-2 to measure how long the immunity benefits of Pfizer and Moderna vaccines last and how well they protect from newer variants. Study participants were selected from a racially and ethnically diverse community-based sample of Chicago-area adults recruited at the start of the pandemic.

Also Read: Pfizer Jab Side Effects In 12–15-Year-Olds At High Risk Of COVID-19 Complications, Mild To Moderate: Study

Using at-home antibody testing kits developed in the lab, participants submitted blood samples two to three weeks after their first and second dose of vaccination and two months after the second dose. In the lab, the researchers tested for neutralising antibodies by measuring whether the blood sample could inhibit the interaction between the virus’ spike protein and the ACE2 receptor — this interaction is how the virus causes an infection once it enters the body.

“When we tested blood samples from participants collected about three weeks after their second vaccine dose, the average level of inhibition was 98 per cent, indicating a very high level of neutralising antibodies,” said McDade, professor of anthropology in the Weinberg College of Arts and Sciences and a faculty fellow with the University’s Institute for Policy Research.

Also Read: COVID-19 Bigger Blood Clot Threat Than Vaccines, UK Study Finds

The scientists tested emerging variants B.1.1351 (South Africa), B.1.1.7 (UK) and P.1 (Brazil) and found the level of inhibition to viral variants was significantly lower, ranging from 67 per cent to 92 per cent. In testing samples collected two months after the second dose, they found antibody responses declined by about 20 per cent.

The researchers found that the antibody response to vaccination varied based on the history of prior infection. Individuals with clinically confirmed cases of COVID-19 and multiple symptoms had a higher level of response than those who tested positive but had mild symptoms or were asymptomatic.

Many people, and many doctors, are assuming that any prior exposure to SARS-CoV-2 will confer immunity to re-infection. Based on this logic, some people with prior exposure don’t think they need to get vaccinated, McDade said.

“Or if they do get vaccinated, they think that they only need the first dose of the two-dose Pfizer/Moderna vaccines,” McDade added.

Also Read: Half Of Hospitalised Covid Patients Have Persisting Symptoms After A Year: Lancet Study

Our study shows that prior exposure to SARS-CoV-2 does not guarantee a high level of antibodies, nor does it guarantee a robust antibody response to the first vaccine dose, McDade continued.

“For people who had mild or asymptomatic infections, their antibody response to vaccination is essentially the same as it is for people who have not been previously exposed,” McDade explained.

McDade added that although the research was conducted prior to the emergence of the delta virus, the conclusions are similar.

“As far as protection goes after vaccination, the story is the same for all the variants, including delta — the vaccine provides good protection, but not as good protection as the original version of the virus for which the vaccine was designed,” McDade said.

“Combine that with the fact that immunity wanes over time, you get increased vulnerability to breakthrough infection. So, it’s two strikes right now — delta plus waning immunity among the first wave of the vaccinated,” McDade concluded.

Also Read: What Are COVID-19 Breakthrough Infections? How Long Does Immunity Last After COVID-19 Vaccination? An Expert Explains

(This story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

24,29,84,542Cases
20,45,14,204Active
3,35,32,126Recovered
49,38,212Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 24,29,84,542 and 49,38,212 have died; 20,45,14,204 are active cases and 3,35,32,126 have recovered as on October 23, 2021 at 3:51 am.

India

3,41,59,562 16,326Cases
1,73,7282,017Active
3,35,32,126 17,677Recovered
4,53,708 666Deaths
In India, there are 3,41,59,562 confirmed cases including 4,53,708 deaths. The number of active cases is 1,73,728 and 3,35,32,126 have recovered as on October 23, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,99,850 1,632

27,747 152

64,32,138 1,744

1,39,965 40

Kerala

48,97,884 9,361

81,490 603

47,88,629 9,401

27,765 563

Karnataka

29,85,227 378

8,920 97

29,38,312 464

37,995 11

Tamil Nadu

26,92,949 1,152

13,531 259

26,43,431 1,392

35,987 19

Andhra Pradesh

20,62,781 478

5,398 102

20,43,050 574

14,333 6

Uttar Pradesh

17,10,069 1

85 22

16,87,085 23

22,899

West Bengal

15,84,492 846

7,577 42

15,57,882 792

19,033 12

Delhi

14,39,526 38

340 29

14,14,095 8

25,091 1

Odisha

10,37,523 467

4,197 139

10,25,025 603

8,301 3

Chhattisgarh

10,05,799 26

214 8

9,92,013 18

13,572

Rajasthan

9,54,396 1

32 4

9,45,410 5

8,954

Gujarat

8,26,378 25

165 9

8,16,126 16

10,087

Madhya Pradesh

7,92,729 8

80 8

7,82,126 16

10,523

Haryana

7,71,133 8

122 9

7,60,962 17

10,049

Bihar

7,26,045 3

30 0

7,16,354 3

9,661

Telangana

6,69,932 193

3,963 4

6,62,025 196

3,944 1

Assam

6,08,126 315

3,866 104

5,98,296 209

5,964 2

Punjab

6,02,163 28

230 4

5,85,382 24

16,551

Jharkhand

3,48,562 36

183 17

3,43,244 19

5,135

Uttarakhand

3,43,799 12

166 10

3,36,235 22

7,398

Jammu And Kashmir

3,31,494 108

870 56

3,26,195 52

4,429

Himachal Pradesh

2,22,312 174

1,483 31

2,17,096 141

3,733 2

Goa

1,77,819 54

600 18

1,73,862 72

3,357

Puducherry

1,27,621 57

454 0

1,25,314 56

1,853 1

Manipur

1,23,107 56

906 440

1,20,294 494

1,907 2

Mizoram

1,16,689 745

9,636 398

1,06,653 1,143

400

Tripura

84,376 7

98 7

83,462 14

816

Meghalaya

83,269 59

698 37

81,128 94

1,443 2

Chandigarh

65,320 5

28 2

64,472 3

820

Arunachal Pradesh

55,075 10

141 1

54,654 9

280

Sikkim

31,842 23

183 2

31,266 25

393

Nagaland

31,689 19

245 5

30,766 23

678 1

Ladakh

20,896

40 3

20,648 3

208

Dadra And Nagar Haveli

10,679 1

4 0

10,671 1

4

Lakshadweep

10,365

0 0

10,314

51

Andaman And Nicobar Islands

7,646

6 1

7,511 1

129

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