Coronavirus Vaccine: Oxford University’s COVID-19 Vaccine Candidate Exhibits Strong Immune Responses, Says The Lancet Study

Coronavirus Vaccine: Oxford University’s COVID-19 Vaccine Candidate Exhibits Strong Immune Responses, Says The Lancet Study

According to the data published in The Lancet, the first phase of human trial of the vaccine candidate ChAdOx1 nCoV-19 developed at the University of Oxford has shown encouraging results and appears to induce strong immune response within the body
Coronavirus Vaccine, News
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  • Phase-I trial for the ChAdOx1 nCoV-19 vaccine involved 1,077 people
  • The vaccine is made from a harmless chimpanzee virus
  • The vaccine is able to generate both humoural and T-cells immunity response

New Delhi: The preliminary data of the COVID-19 candidate vaccine developed by the University of Oxford has shown encouraging results in first stage of the vaccine development. The study titled ‘Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial’ revealed the findings of the human trial of the vaccine and was published in the medical journal The Lancet on Monday. According to the study, early human testing of Oxford University’s vaccine called ChAdOx1 nCoV-19 found that it produced expected immune responses and was safely tolerated by the subjects during the trial.

Also Read: Serum Institute To Produce COVID-19 Vaccine Candidate Developed By Oxford University, Will Be Called Covishield In India

The Lancet study says that Oxford’s candidate vaccine is made from a harmless chimpanzee virus. The human trials of ChAdOx1 nCoV-19 vaccine that began in April this year involved 1,077 healthy adults aged between 18 and 55 in five hospitals in the United Kingdom. The study found that after receiving the injection, the immune system of the volunteers was triggered which led to the making of antibodies and white blood cells called T-cell specific to antigen or the substance carried by coronavirus. It was also found that after two doses of the vaccine, administered at an interval of 28 days, potent immunogenicity, which is the ability to induce immune response to foreign substance such as an antigen was present in all the participants studied. The results show that the vaccine could induce immune responses for up to 56 days after being injected.

Lead Researchers Pedro M Folegatti and Katiet Ewer, wrote in paper published in The Lancet,

Our preliminary findings show that the candidate ChAdOx1 nCoV-19 vaccine given as a single dose was safe and tolerated. No serious adverse reactions to ChAdOx1 nCoV-19 occurred. The majority of adverse events reported were mild or moderate in severity, and all were self-limiting.

Explaining about the immune responses produced by the ChAdOx1 nCoV-19 vaccine Padma Shri Awardee, Dr KK Aggarwal, President, Confederation of Medical Associations in Asia and Oceania (CMAAO) and Medtalks, Heart Care Foundation of India who has been involved in the treatment of over 2,000 COVID-19 patients in Delhi said,

It is first important to understand the functioning of a vaccine. Think of the virus as a terrorist and body’s immune system as the Police. Vaccination is simply a mock drill for this Police. This means that body is injected with some other virus similar to the virus in consideration or an artificially generated synthetic virus or the virus itself but in a neutralised form. This triggers body’s immune system to use its weapons and activates the humoural immunity which forms antibodies specific to the foreign substance or antigen that has invaded the body. Some vaccines trigger the immune system to call its reserved force, the T-Cells. These are White Blood Cells that have the ability to recognise the antigen on being encountered again and help in producing antibodies that can kill those specific antigens. It also has the capacity to kill bad or infected cells. T-cells are crucial for maintaining protection against the virus for years. Some vaccines have the capacity to induce both, humoural immunity as well as the T-Cell immunity. Oxford’s COVID-19 vaccine candidate is the latter kind. It has been able to induce both kinds of immunity.

However, Dr Aggarwal also added that while the findings are seen as promising, it is too soon to know if this is enough to offer protection to the people against the virus. He said that it has been only three months since the vaccine was administered among the volunteers and it is still not known how long the immunity would last. He said,

During the early trials the Oxford researchers found that by giving a second dose, the immune response was better. However, it is still not clear if this is enough. So, how much dose is required is not known. There is also a need to watch out for the post-vaccination impacts till at least one year. We must wait till the phase three result come which is currently being conducted on volunteers in Brazil, South Africa and the UK and probably soon in India, before there is any decision on which of the multiple vaccines under development can provide maximum protection.

Also Read: Phase II Trial Finds Chinese COVID-19 Vaccine Is Safe, Induces Immune Response: Lancet Study

The vaccine is still undergoing the phase II and III of clinical development as per the study report. In these phases, older age groups with comorbidities, health-care workers, and those with higher risk for SARS-CoV-2 exposure are being recruited and assessed for efficacy, safety and the ability to induce an immune response after the vaccine is given to them. The researchers will also evaluate the vaccine in children, once sufficient safety data has been accumulated in adult studies. Professor Sarah Gilbert, co-author of the study said,

There is still much work to be done before we can confirm if our vaccine will help manage the COVID-19 pandemic, but these early results hold promise. We still need to learn more about the virus. We still do not know how strong an immune response we need to provoke to effectively protect against SARS-CoV-2 infection. If our vaccine is effective, it is a promising option as these types of vaccine can be manufactured at a large scale.

The University of Oxford has partnered with the UK-based global bio-pharmaceutical company AstraZeneca for further development, large-scale manufacture and potential distribution of the COVID-19 vaccine. In India, Serum Institute of India (SII), the world’s largest vaccine manufacturer, has taken up the charge of producing the vaccine being developed by Oxford University and AstraZeneca. It will be called as Covishield in the country. According to Adar Poonawala, CEO, SII, it is most likely to be launched in the country by November this year.

According to Centres for Disease Control and Prevention (CDC), a national public health institute in the United States, the development cycle of a vaccine includes following seven stages:

1. Exploratory stage: This is a research-intensive phase to identify natural or synthetic antigens- a substance that causes the immune system to produce antibodies, that might help prevent or treat a disease by inducing immune responses

2. Pre-Clinical stage: During this phase, researchers conduct animal testing to determine whether the candidate vaccine will produce immunity

3. Clinical development stage: This stage is a human trial stage and includes three-phase process. During Phase I, small groups of people receive the trial vaccine. In Phase II, the clinical study is expanded and vaccine is given to people who have characteristics (such as age and physical health) similar to those for whom the new vaccine is intended. In Phase III, the vaccine is given to thousands of people and tested for efficacy and safety.

4. Regulatory review and approval stage: If a vaccine passes through all three phases of clinical development, the vaccine developer submits applications for license and approval with the health authorities.

6. Manufacturing stage: In this stage, vaccine manufacturers provide the infrastructure, personnel and equipment necessary to create mass quantities of vaccines.

7. Quality control stage: This stage involves tracking the immunisation and see whether the vaccines is performing as anticipated.

Apart from the Oxford University’s product, there are more than 100 vaccine candidates under various stages of development across the world, according to the World Health Organisation (WHO). Some of these include, American biotech company Moderna’s COVID-19 vaccine of which the phase-I findings of human trial were published recently prompted neutralising antibody activity, though minor side effects were observed in many patients. China’s CanSino coronavirus vaccine is currently under phase-III trial in Bangladesh and has shown positive results in Phase-I and II, according to Dr. Aggarwal. India’s COVID-19 vaccine candidate Covaxin developed jointly by Bharat Biotech and Indian Council of Medical Research (ICMR) has recently started phase-I of the human trial. Other firms in the country like Serum Institute of India, Zydus Cadila and Indian Immunologicals Limited are also involved in developing a vaccine with an aim to help end the pandemic.

Also Read: COVID-19 Vaccine Likely By End Of This Year Or Early Next Year: AIIMS Doctor

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene


Coronavirus has spread to 193 countries. The total confirmed cases worldwide are 17,66,30,634 and 38,22,022 have died; 5,80,25,717 are active cases and 11,47,82,895 have recovered as on June 16, 2021 at 3:30 am.


2,96,33,105 62,224Cases
2,83,88,100 1,07,628Recovered
3,79,573 2,542Deaths
In India, there are 2,96,33,105 confirmed cases including 3,79,573 deaths. The number of active cases is 8,65,432 and 2,83,88,100 have recovered as on June 16, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths

59,24,773 7,652

1,41,440 8,982

56,69,179 15,176

1,14,154 1,458


27,77,010 5,041

1,62,303 9,859

25,81,559 14,785

33,148 115


27,48,204 12,246

1,12,792 1,456

26,23,904 13,536

11,508 166

Tamil Nadu

23,78,298 11,805

1,25,215 11,669

22,23,015 23,207

30,068 267

Andhra Pradesh

18,20,134 5,741

75,134 4,879

17,32,948 10,567

12,052 53

Uttar Pradesh

17,03,207 270

7,221 890

16,74,072 1,104

21,914 56

West Bengal

14,68,044 3,268

20,046 1,125

14,30,949 2,068

17,049 75


14,31,498 228

3,078 148

14,03,569 364

24,851 12


9,88,172 609

11,717 943

9,63,113 1,544

13,342 8


9,50,133 172

5,619 848

9,35,658 1,006

8,856 14


8,59,526 3,405

44,358 3,436

8,11,780 6,799

3,388 42


8,21,078 352

8,884 658

8,02,187 1,006

10,007 4

Madhya Pradesh

7,88,649 224

3,610 331

7,76,424 528

8,615 27


7,66,357 228

3,703 374

7,53,584 564

9,070 38


7,17,949 410

4,360 412

7,04,075 813

9,514 9


6,06,436 1,556

19,933 528

5,82,993 2,070

3,510 14


5,89,153 628

10,802 1,111

5,62,701 1,691

15,650 48


4,66,590 3,415

41,184 475

4,21,378 2,906

4,028 34


3,43,793 184

2,646 416

3,36,058 596

5,089 4


3,37,449 274

3,642 266

3,26,822 515

6,985 25

Jammu And Kashmir

3,08,726 715

12,407 1,125

2,92,114 1,830

4,205 10

Himachal Pradesh

1,99,197 321

4,050 382

1,91,737 691

3,410 12


1,63,048 327

4,175 231

1,55,926 548

2,947 10


1,13,192 355

4,668 279

1,06,828 629

1,696 5


61,200 40

486 21

59,917 58

797 3


61,096 785

8,744 301

51,354 476

998 8


60,385 536

4,886 65

54,870 596

629 5


42,759 450

4,430 99

37,579 542

750 7

Arunachal Pradesh

31,938 290

2,849 40

28,934 326

155 4


23,854 101

2,972 229

20,423 327

459 3


19,649 38

552 20

18,898 57

199 1


18,659 209

3,239 67

15,136 273

284 3


15,899 268

3,637 45

12,191 312

71 1

Dadra And Nagar Haveli

10,473 9

61 2

10,408 7



9,297 61

484 36

8,768 96

45 1

Andaman And Nicobar Islands

7,280 11

105 4

7,049 15


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