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COVID-19: Indigenous Monoclonal Antibodies Drug’s Production At Low Cost Can Be ‘Game Changer’ For India, Say Experts

The antibody cocktail shot came into the limelight after it was used to treat former United States President Donald Trump from COVID-19 last year

COVID-19: Indigenous Monoclonal Antibodies Drug's Production At Low Cost Can Be 'Game Changer' For India, Say Experts
Highlights
  • Antibodies are proteins generates by the body to defend against a disease
  • An antibody cocktail is administered intravenously or under the skin
  • The therapy is a cocktail of two monoclonal antibodies

New Delhi: Monoclonal antibody drug production in India at reasonable price could be a “game changer” for the country in its fight against COVID-19, said Dr Arvinder S Soin, Chairman, Institute of Liver Transplant and Regenerative Medicine at Medanta Hospital on Sunday (May 30). “If these (Monoclonal antibody drug) are made in large enough quantities at a reasonable price. The monoclonal antibodies could be a game changer for India and the world, and especially for high risk elderly patients and children. There may come a time of the year when anyone testing positive can have monoclonal antibodies, and to avoid serious disease, we should adopt these early,” Dr Soin told ANI here.

Also Read: Coronavirus Warrior: Hyderabad Doctor Treats COVID-19 Patients For Just Rs. 10

Dr Soin also pointed out 3 specific drugs (monoclonal antibodies drug) authorised by the US Food and Drug Administration (FDA) and one by India’s Central Drugs Standard Control Organisation (CDSCO) can ‘nip COVID infection in the bud’. He further said,

There are three specific drugs in the form of monoclonal antibodies against the viral spike protein that have been authorised for emergency use by the US FDA, and one by the CDSCO, India. These can nip COVID infection in the bud, if given soon after testing positive but certainly in the first week. So these can prevent severe disease and deaths, if given at home early during the infection.

Further elaborating the drug combinations, Dr Soin said,

First is the Casirivimab and Imdevimab combination that is available in India. It’s been tested in over 20,000 patients and is 70 per cent effective in preventing hospitalisation and death. Similarly, two more treatments is a combination of bamlanivinab and Etesevimab is 70 per cent effective and the latest one Sotrovimab is 85 per cent effective in preventing severe disease, if given early.

Also Read: Over 100 Inflammatory Syndrome Cases Reported Among Children In North India As Post-COVID Reaction

Echoing the similar sentiment, Dr Nirmal K Ganguly, former Director-General, ICMR expressed that Monoclonal antibodies work as they are made against targeted epitopes.

Since this (monoclonal antibody) is a highly expensive product, don’t use it for all COVID-infected individuals. Use it only for those with severe infection, are hospitalised, at very high risk and with higher chances of mortality, Dr Ganguly added.

The former ICMR DG further said that there are six receptor-binding domain points that are important in spike protein, which undergo mutation/functional enhancement to create specific monoclonal antibodies. Former head scientist epidemiology and communicable disease at ICMR, Dr Raman R Gangakhedkar said,

We can’t say they (rational use of plasma and Remdesivir) are the only reasons for variants. In the next few days, we will get to know how monoclonal antibodies will work against COVID and its variants.

Also Read: Anticipating Third Wave Of COVD-19, Indian Academy Of Pediatrics Train 6,000 Pediatricians To Handle Adult Patients

The antibody cocktail shot came into the limelight after it was used to treat former United States President Donald Trump last year. The therapy is said to reduce the chance of hospitalisation by 70 per cent in patients with mild to moderate COVID-19 symptoms. The therapy is a cocktail of two monoclonal antibodies. Antibodies are proteins that the body generates to defend itself against any disease. Monoclonal antibodies are artificially created in a laboratory and tailor-made to fight a particular disease. Casirivimab and imdevimab, which are part of the antibody cocktail produced by Switzerland-based Roche, are specifically directed against the spike protein of SARS-CoV-2. They block the virus’ attachment and its subsequent entry into human cells. Use of two antibodies protects against the body’s resistance to them. An antibody cocktail is administered intravenously or subcutaneously (under the skin) as an injection. Presently, it is being administered at Medanta Hospital in Gurugram, Haryana and Delhi’s Fortis Escorts Heart Institute and Apollo Hospital. Zydus Cadila has also sought approval for early-to late-stage human trials of its antibody cocktail candidate, ZRC-3308, to treat mild COVID-19 patients.

Also Read: Sputnik V COVID-19 Vaccine To Be Rolled Out Across Apollo Hospitals, Will Cost Rs. 1,195 Per Dose

(This story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

24,50,12,529Cases
20,64,25,824Active
3,36,14,434Recovered
49,72,271Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 24,50,12,529 and 49,72,271 have died; 20,64,25,824 are active cases and 3,36,14,434 have recovered as on October 28, 2021 at 4:00 am.

India

3,42,31,809 16,156Cases
1,60,9891,672Active
3,36,14,434 17,095Recovered
4,56,386 733Deaths
In India, there are 3,42,31,809 confirmed cases including 4,56,386 deaths. The number of active cases is 1,60,989 and 3,36,14,434 have recovered as on October 28, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

66,06,536 1,485

23,096 3,500

64,43,342 4,947

1,40,098 38

Kerala

49,38,603 9,445

77,158 2,100

48,31,468 6,723

29,977 622

Karnataka

29,86,835 282

8,459 80

29,40,339 349

38,037 13

Tamil Nadu

26,98,493 1,075

12,288 252

26,50,145 1,315

36,060 12

Andhra Pradesh

20,64,854 567

4,777 122

20,45,713 437

14,364 8

Uttar Pradesh

17,10,114 13

100 6

16,87,115 7

22,899

West Bengal

15,89,042 976

7,973 124

15,61,973 837

19,096 15

Delhi

14,39,709 38

348 25

14,14,270 13

25,091

Odisha

10,39,818 549

4,392 213

10,27,108 334

8,318 2

Chhattisgarh

10,05,926 28

263 14

9,92,088 12

13,575 2

Rajasthan

9,54,411 4

20 0

9,45,437 4

8,954

Gujarat

8,26,481 17

173 2

8,16,220 15

10,088

Madhya Pradesh

7,92,804 20

108 9

7,82,172 10

10,524 1

Haryana

7,71,204 15

133 5

7,61,022 10

10,049

Bihar

7,26,073 5

41 1

7,16,371 4

9,661

Telangana

6,70,829 186

4,164 63

6,62,714 122

3,951 1

Assam

6,09,506 244

3,838 153

5,99,681 391

5,987 6

Punjab

6,02,289 38

246 20

5,85,487 16

16,556 2

Jharkhand

3,48,705 28

160 30

3,43,408 56

5,137 2

Uttarakhand

3,43,861 17

150 6

3,36,312 23

7,399

Jammu And Kashmir

3,31,865 70

838 16

3,26,596 86

4,431

Himachal Pradesh

2,23,406 261

1,972 211

2,17,693 48

3,741 2

Goa

1,77,969 23

454 29

1,74,152 51

3,363 1

Puducherry

1,27,846 40

443 10

1,25,546 50

1,857

Manipur

1,23,473 70

844 29

1,20,712 97

1,917 2

Mizoram

1,19,496 547

7,320 446

1,11,752 991

424 2

Tripura

84,438 15

123 1

83,499 14

816

Meghalaya

83,466 51

507 22

81,511 71

1,448 2

Chandigarh

65,331 5

29 2

64,482 3

820

Arunachal Pradesh

55,120 6

115 22

54,725 28

280

Sikkim

31,925 13

177 1

31,353 12

395

Nagaland

31,759 12

222 3

30,856 15

681

Ladakh

20,925 8

47 6

20,670 2

208

Dadra And Nagar Haveli

10,682 1

6 0

10,672 1

4

Lakshadweep

10,365

0 0

10,314

51

Andaman And Nicobar Islands

7,650 2

5 1

7,516 1

129

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