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Monoclonal Antibody Cocktail Unlikely To Cause Further Mutations Of COVID-19: Former ICMR Head Scientist Dr RR Gangakhedkar

The antibody cocktail therapy is not recommended for patients who are hospitalised due to severe COVID-19, or those who require oxygen therapy due to COVID-19 or underlying non-COVID-19 related comorbidity

Monoclonal Antibody Cocktail Unlikely To Cause Further Mutations Of COVID-19: Former ICMR Head Scientist Dr RR Gangakhedkar

New Delhi: Monoclonal antibody cocktail, used for the treatment of COVID-19, is unlikely to lead to further mutation of the virus, said Dr Raman R Gangakhedkar, former Head Scientist of Epidemiology and Communicable Diseases at the Indian Council of Medical Research (ICMR) on Sunday (May 30). Speaking to ANI, Dr Gangakhedkar also said that when a person develops moderate to severe illness, it’s more likely due to a dysregulated immune response rather than the virus itself. “I don’t think that it will lead to mutation theory-wise because we know when the person develops moderate to severe illness we also know that it’s more likely due to dysregulated immunity response rather than the virus itself. So if there is no virus then it will not mutate under pressure,” he said.

Also Read: COVID-19: Indigenous Monoclonal Antibodies Drug’s Production At Low Cost Can Be ‘Game Changer’ For India, Say Experts

He, however, added,

But as I said, rationale use based on evidence is vital to be promoted these monoclonal antibodies which we want to use if one to use it one should use it as early as possible within three days of detection or a maximum of ten days.

He further said that there was no data on how monoclonal antibodies protect people against the new variants. Asked if plasma therapy and Remedesivir have helped in reducing Covid virus mutation, Dr Gangakhedkar said,

All evidence shows that viruses tend to mutate since they have error-prone enzymes. When they reproduce, they are likely to produce a virus that may have a minor mutation. This particular virus accumulates one mutation in almost two weeks time in the population.

Also Read: Kerala To Issue COVID-19 Vaccination Certificates With Passport Numbers

“Now, if you put a selection pressure additionally of either an ineffective drug or you put a selection pressure from convalescent plasma by exposing that individual to multiple antibodies, neutralising the antibodies you will find that will also act,” Dr Gangakhedkar said.

He further quoted one of the studies done for Cambridge that showed that use of repeated convalescent plasma adds up to mutations dramatically.

There are reasons to believe that we need to be cautious. No government has come with guidelines that convalescent plasma use shouldn’t be done in management. For Remdesivir, the guidelines tend to say that unless you have moderate to severe disease, you shouldn’t use Remedesivir, he added.

The first person to be administered the antibody therapy was an 84-year old male Covid-positive patient in Gurgaon who went back to his home on May 27. He has become the first person in India to be administered the COVID drug cocktail, which came into the limelight after it was administered to former US President Donald Trump when he tested positive for the virus last year.

Also Read: Coronavirus Warrior: Hyderabad Doctor Treats COVID-19 Patients For Just Rs. 10

The antibody cocktail therapy is not recommended for patients who are hospitalized due to severe COVID-19, or those who require oxygen therapy due to COVID-19 or who require an increase in baseline oxygen flow rate due to the disease and in patients on chronic oxygen therapy due to underlying non-Covid-19 related comorbidity. This FDA-approved therapy demonstrated good efficacy in Phase 1/2 and Phase 3 studies by reducing COVID-19 related hospitalization and death by 70 per cent. Approved by the Drugs Controller General of India (DCGI), this single dose infusion-based treatment can be provided on an outpatient or day care basis and marks a dramatic shift in coronavirus care in India.

Also Read: Over 100 Inflammatory Syndrome Cases Reported Among Children In North India As Post-COVID Reaction

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

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World

22,70,55,138Cases
18,97,86,461Active
3,25,98,424Recovered
46,70,253Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 22,70,55,138 and 46,70,253 have died; 18,97,86,461 are active cases and 3,25,98,424 have recovered as on September 17, 2021 at 5:36 am.

India

3,33,81,728 34,403Cases
3,39,0563,867Active
3,25,98,424 37,950Recovered
4,44,248 320Deaths
In India, there are 3,33,81,728 confirmed cases including 4,44,248 deaths. The number of active cases is 3,39,056 and 3,25,98,424 have recovered as on September 17, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,11,525 3,595

52,893 310

63,20,310 3,240

1,38,322 45

Kerala

44,46,228 22,182

1,86,754 4,559

42,36,309 26,563

23,165 178

Karnataka

29,65,191 1,108

16,202 282

29,11,434 808

37,555 18

Tamil Nadu

26,40,361 1,693

16,756 120

25,88,334 1,548

35,271 25

Andhra Pradesh

20,34,786 1,367

14,708 105

20,06,034 1,248

14,044 14

Uttar Pradesh

17,09,628 23

193 11

16,86,549 11

22,886 1

West Bengal

15,59,567 707

8,025 25

15,32,922 725

18,620 7

Delhi

14,38,373 28

409 5

14,12,880 22

25,084 1

Odisha

10,18,298 580

5,335 105

10,04,845 681

8,118 4

Chhattisgarh

10,04,988 31

352 2

9,91,077 29

13,559

Rajasthan

9,54,230 4

103 1

9,45,173 5

8,954

Gujarat

8,25,677 22

149 0

8,15,446 22

10,082

Madhya Pradesh

7,92,374 7

119 5

7,81,738 12

10,517

Haryana

7,70,697 9

327 8

7,60,562 17

9,808

Bihar

7,25,864 12

72 6

7,16,134 6

9,658

Telangana

6,62,785 259

5,282 43

6,53,603 301

3,900 1

Punjab

6,01,180 30

314 11

5,84,399 38

16,467 3

Assam

5,97,074 468

5,381 15

5,85,914 479

5,779 4

Jharkhand

3,48,102 6

102 8

3,42,867 14

5,133

Uttarakhand

3,43,330 20

284 12

3,35,657 32

7,389

Jammu And Kashmir

3,27,466 170

1,421 72

3,21,630 98

4,415

Himachal Pradesh

2,16,430 127

1,568 82

2,11,215 206

3,647 3

Goa

1,75,183 95

699 1

1,71,195 96

3,289

Puducherry

1,25,170 107

963 63

1,22,380 42

1,827 2

Manipur

1,17,913 216

2,614 7

1,13,478 219

1,821 4

Tripura

83,787 31

427 26

82,553 56

807 1

Meghalaya

78,958 229

1,804 140

75,784 86

1,370 3

Mizoram

76,591 1,121

13,888 85

62,449 1,202

254 4

Chandigarh

65,168 4

31 2

64,319 2

818

Arunachal Pradesh

53,990 47

536 9

53,183 56

271

Sikkim

30,802 64

775 28

29,648 36

379

Nagaland

30,763 32

505 14

29,610 44

648 2

Ladakh

20,631 6

41 1

20,383 5

207

Dadra And Nagar Haveli

10,670

5 0

10,661

4

Lakshadweep

10,353

4 0

10,298

51

Andaman And Nicobar Islands

7,595 3

15 2

7,451 1

129

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