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COVID-19 Vaccine Race: Where They Stand Currently

As India prepares to launch its vaccine drive against coronavirus on January 16, here is a look at the COVID-19 vaccine options available worldwide

COVID-19 Vaccine Race: Where They Stand Currently
Highlights
  • Covishield is developed by Oxford and British-Swedish firm AstraZeneca
  • Moderna and Pizer-BioNTech have developed mRNA vaccines against COVID-19
  • Moderna has so far been approved for use in Israel, the EU, Canada, the US

New Delhi: Almost a year into the COVID-19 pandemic, about 200 vaccine candidates are in the works and 10 have been either approved by several countries or are under limited emergency use. As India prepares to launch its vaccine drive on January 16, here is a look at the options:

Also Read: As India Gears Up To Kick-starts COVID-19 Vaccination Drive From January 16, Expert Explains When Will The Common Man Get The Vaccine

Covaxin

Developed by Bharat Biotech in collaboration with the Indian Council of Medical Research and the National Institute of Virology, the indigenous vaccine was granted emergency use authorisation in ‘clinical trial mode’ by the Indian government this week. It is an “inactivated” vaccine developed by chemically treating novel coronavirus samples to make them incapable of reproduction. This process leaves the viral proteins, including the spike protein of the coronavirus which it uses to enter the human cells, intact.

Given as two doses, three weeks apart, the viral proteins in the vaccine activate the immune system and prepare people for future infections with the actual infectious virus. According to Bharat Biotech, the therapeutic can be stored at room temperature for at least a week. A study on the Phase 1/2 trial published in the preprint server medRxiv in December showed the therapeutic doesn’t cause any serious side effects. However, there has been no further data released in the public domain which could demonstrate that the vaccine is safe and effective.

ICMR-Bharat Biotech vaccine is a killed whole-virus vaccine and there are absolutely no data available so far on its protective efficacy. I am critical of its getting approval by the authorities, immunologist Vineeta Bal, affiliated with the National Institute of Immunology in New Delhi, told PTI.

Covishield

Co-developed by the University of Oxford and British-Swedish company AstraZeneca and known as Covishield in India, the vaccine was the first on which a scientific study was published based on Phase 3 clinical trials. It has so far been given emergency use authorization in the UK, Argentina, Mexico and India. Scientists have engineered a version of adenoviruses that infect chimpanzees to carry the gene responsible for the spike protein of the novel coronavirus. It requires two doses, provided four weeks apart, to produce the desired effects.

Manufactured by the Serum Institute of India, Covishield will be sold at Rs. 1,000 per dose in the private market but cost the Indian government only Rs 200, said SII CEO Adar Poonawalla.

Oxford-AstraZeneca-Serum Institute vaccine has shown protective efficacy in global trials to the tune of 60-70 per cent. While clear data from bridging trials in India are not available, the vaccine is certainly proven safe, Ms. Bal said.

According to virologist Upasana Ray from the CSIR-Indian Institute of Chemical Biology, Kolkata, the AstraZeneca-Oxford vaccine is less restricted in terms of cold storage as it can be stored, transported and handled at normal refrigerator temperatures (2-8 degrees Celsius) for at least six months.

Also Read: COVID-19 Vaccination To Start In India On Jan 16; 3 Crore Healthcare, Frontline Workers To Get Shots First

Moderna

The mRNA vaccine by US-based company Moderna has so far been approved for use in Israel, the EU, Canada and the US. A study of the efficacy of Moderna vaccine revealed it has 94.1 per cent efficacy in preventing the disease. In this type of vaccine, the messenger RNA — or mRNA — acts as a blueprint for the production of the coronavirus spike protein and is encapsulated by lipid molecules and delivered into human cells.

The cells of the vaccine recipient then use this mRNA genetic code to produce the viral protein to train the immune system for a future encounter with the infectious coronavirus. Administered as two doses, four weeks apart, the Moderna vaccine can reportedly be stored in the refrigerator at 2-8 degrees Celsius for up to 30 days. At -20 degrees Celsius it can be stored for up to six months.

This is still a challenge for many developing countries in the tropical regions that experience very high temperatures in the summer months.

In November last year, Moderna Chief Executive Stephane Bancel told a German weekly that the company would charge governments between USD 25 and 37 per dose of its COVID-19 vaccine candidate, depending on the amount ordered.

Pfizer-BioNtech

The US-backed Pfizer-Biontech’s COVID-19 preventive, like the Moderna vaccine, is based on the segments of the genetic material of the novel coronavirus. Preliminary data from the clinical trials showed that two doses of the vaccine, given three weeks apart, provided an efficacy of over 90 per cent. Following the results, the UK, Canada, the EU and Saudi Arabia have approved the Pfizer vaccine for use.

Several countries, including the US, Singapore, Argentina and Mexico, have given emergency use authorisation. One limitation for the Pfizer vaccine has been its requirement for ultracold storage — up to -70 degrees Celsius. Each dose is reportedly priced at USD 37.

Sputnik V

Sputnik V from Russia’s Gamaleya Research Institute has been approved for emergency use by several countries but awaits more results from Phase 3 trials. An adenovirus vectored vaccine, Sputnik V is produced using a combination of two adenoviruses called Ad5 and Ad26. Preliminary evidence from Phase 3 trials indicates it is 90 per cent effective when given as two doses, three weeks apart.

In November, the Russian Direct Investment Fund said the cost of the vaccine would be less than USD 10 per dose starting from February 2021. It said the dry form of the vaccine can be stored at 2-8 degrees Celsius, and does not need freeze storage.

Also Read: Amid Short Supplies, Vaccine Doses Can Be Six Weeks Apart, Says WHO

Convidecia

The adenovirus vectored vaccine developed by the Chinese company CanSino Biologics is also under Phase 3 trials and has already been approved for limited use by the Chinese military. Since August, the vaccine has been part of Phase 3 trials in several countries, including Russia, Mexico and Pakistan.

Coronavac

Another Chinese company, Sinopharm, has also made progress with its inactivated vaccine dubbed CoronaVac. It has been given emergency approval for limited use in the country. The vaccine is reportedly provided as two doses, administered two weeks apart. Scientists are yet to publish a study on the trial conducted so far.

Vector Institute

Russia’s Vector Institute has developed a protein vaccine. It is currently under Phase 3 clinical trials. It uses modified versions of the coronavirus spike protein to induce immunity. The vaccine reportedly can be stored at 2-8 degrees celsius for up to two years. Data on the efficacy of the therapeutic is yet to be released.

Novavax

After showing promising results in Phase 1-2 trials, and in animal experiments, the vaccine developed by US company Novavax is currently under Phase 3 clinical trials. It uses modified versions of the coronavirus spike protein to induce immunity, and can reportedly be stored at 2-8 degrees Celsius. After some setbacks in manufacturing the doses required for the Phase 3 study in the US, the trial was finally launched on December 28.

Johnson & Johnson

The adenovirus vectored vaccine by the American company has shown protection against the coronavirus in experiments in monkeys and is currently part of Phase 3 clinical trials. Unlike other vaccines, this vaccine is reportedly provided as a single dose, but trials are currently underway to test its efficacy as two doses. The company had noted that the therapeutic can be stored for up to three months when refrigerated at 2-8 degrees Celsius, and up to two years when frozen at -20 degrees Celsius.

Also Read: India Will Be Able To Vaccinate Entire Population Against COVID-19 Soon, Says Health Minister Harsh Vardhan

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

24,00,62,413Cases
20,17,73,183Active
3,33,99,961Recovered
48,89,269Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 24,00,62,413 and 48,89,269 have died; 20,17,73,183 are active cases and 3,33,99,961 have recovered as on October 16, 2021 at 4:08 am.

India

3,40,53,573 15,981Cases
2,01,6322,046Active
3,33,99,961 17,861Recovered
4,51,980 166Deaths
In India, there are 3,40,53,573 confirmed cases including 4,51,980 deaths. The number of active cases is 2,01,632 and 3,33,99,961 have recovered as on October 16, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,88,429 2,149

33,379 222

64,15,316 1,898

1,39,734 29

Kerala

48,38,811 8,867

95,349 1,072

47,16,728 9,872

26,734 67

Karnataka

29,82,869 470

9,700 93

29,35,238 368

37,931 9

Tamil Nadu

26,84,641 1,245

15,238 213

26,33,534 1,442

35,869 16

Andhra Pradesh

20,59,708 586

6,453 135

20,38,960 712

14,295 9

Uttar Pradesh

17,10,014 6

133 2

16,86,984 8

22,897

West Bengal

15,79,463 451

7,513 63

15,52,997 506

18,953 8

Delhi

14,39,337 26

327 10

14,13,921 36

25,089

Odisha

10,34,276 467

4,817 73

10,21,180 535

8,279 5

Chhattisgarh

10,05,624 10

197 6

9,91,857 16

13,570

Rajasthan

9,54,383 1

40 2

9,45,389 3

8,954

Gujarat

8,26,258 14

212 3

8,15,960 17

10,086

Madhya Pradesh

7,92,675 6

106 5

7,82,046 11

10,523

Haryana

7,71,049 14

116 11

7,60,884 3

10,049

Bihar

7,26,021 5

46 4

7,16,314 1

9,661

Telangana

6,68,722 104

4,056 115

6,60,730 218

3,936 1

Assam

6,05,944 97

3,458 188

5,96,547 284

5,939 1

Punjab

6,01,992 21

228 6

5,85,224 25

16,540 2

Jharkhand

3,48,415 9

130 0

3,43,150 9

5,135

Uttarakhand

3,43,739 10

179 4

3,36,163 6

7,397

Jammu And Kashmir

3,30,885 51

895 40

3,25,564 91

4,426

Himachal Pradesh

2,21,203 90

1,361 26

2,16,125 114

3,717 2

Goa

1,77,410 54

648 31

1,73,423 81

3,339 4

Puducherry

1,27,296 37

611 36

1,24,836 73

1,849

Manipur

1,22,545 113

1,444 0

1,19,208 109

1,893 4

Mizoram

1,11,651 932

13,316 285

97,955 1,211

380 6

Tripura

84,299 4

102 8

83,381 12

816

Meghalaya

82,815 81

893 1

80,490 79

1,432 1

Chandigarh

65,297 2

30 2

64,447 4

820

Arunachal Pradesh

54,964 6

183 19

54,501 25

280

Sikkim

31,739 17

189 35

31,159 51

391 1

Nagaland

31,547 31

228 2

30,645 32

674 1

Ladakh

20,871 4

42 2

20,621 6

208

Dadra And Nagar Haveli

10,675

3 0

10,668

4

Lakshadweep

10,365

1 1

10,313 1

51

Andaman And Nicobar Islands

7,641 1

9 1

7,503 2

129

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