- 3 main families of coronaviruses cause human disease: Study
- Prior Covid infections can help in preventing subsequent infections
- SARS-CoV-1 and SARS-CoV-2 are genetically similar: Researchers
Washington: COVID-19 vaccines and prior coronavirus infections can provide broad immunity against other, similar coronaviruses, according to a study. The findings, published in the Journal of Clinical Investigation, build a rationale for universal coronavirus vaccines that could prove useful in the face of future epidemics. “Until our study, what hasn’t been clear is if you get exposed to one coronavirus, could you have cross-protection across other coronaviruses? And we showed that is the case,” said study lead author Pablo Penaloza-MacMaster, assistant professor at Northwestern University Feinberg School of Medicine, US.
The three main families of coronaviruses that cause human disease include Sarbecovirus, which includes the SARS-CoV-1 strain responsible for the 2003 outbreak of Severe Acute Respiratory Syndrome (SARS), as well as SARS-CoV-2, which causes COVID-19.
The other two are Embecovirus, which includes OC43, often responsible for the common cold, and Merbecovirus, which is the virus responsible for Middle East Respiratory Syndrome (MERS), first reported in 2012. The study found that plasma from humans who had been vaccinated against SARS-CoV-2 produced antibodies that were cross-reactive, or provided protection, against SARS-CoV-1 and the common cold coronavirus (OC43).
The researchers found that mice immunised with a SARS-CoV-1 vaccine developed in 2004 generated immune responses that protected them from intranasal exposure by SARS-CoV-2. They also found prior coronavirus infections can protect against subsequent infections with other coronaviruses.
Mice that had been immunised with COVID-19 vaccines and later were exposed to the common cold coronavirus (HCoV-OC43) were partially protected against the common cold, but the protection was much less robust, according to the study. The reason, the scientists explained, is because both SARS-CoV-1 and SARS-CoV-2 are genetically similar — like cousins of one another — while the common cold coronavirus is more divergent from SARS-CoV-2.
As long as the coronavirus is greater than 70 per cent related, the mice were protected. If they were exposed to a very different family of coronaviruses, the vaccines might confer less protection, Penaloza-MacMaster said.
Given how different each coronavirus family is, the study authors said a universal coronavirus vaccine may not be possible. However, there may be a path forward for developing a vaccine for each coronavirus family, they said.
Our study helps us re-evaluate the concept of a universal coronavirus vaccine. It’s likely there isn’t one, but we might end up with a generic vaccine for each of the main families of coronaviruses, Penaloza-MacMaster said.
For example, the scientist said, a universal Sarbecovirus vaccine can be made for SARS-CoV-1, SARS-CoV-2 and other SARS-related coronaviruses, and a universal Embecovirus for HCoV-OC43 and HKU1 that cause common colds. In the study, Penaloza-MacMaster and Northwestern Medicine physician Igor Koralnik evaluated immune responses in humans who received SARS-CoV-2 vaccines, as well as in COVID-19 patients admitted to Northwestern Memorial Hospital. “We found that these individuals developed antibody responses that neutralised a common cold coronavirus, HCoV-OC43,” Penaloza-MacMaster said. “We are now measuring how long this cross-protection lasts,” he added.
(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)
NDTV – Dettol have been working towards a clean and healthy India since 2014 via Banega Swachh India initiative, which is helmed by Campaign Ambassador Amitabh Bachchan. The campaign aims to highlight the inter-dependency of humans and the environment, and of humans on one another with the focus on One Health, One Planet, One Future – Leaving No One Behind. It stresses on the need to take care of, and consider, everyone’s health in India – especially vulnerable communities – the LGBTQ population, indigenous people, India’s different tribes, ethnic and linguistic minorities, people with disabilities, migrants, geographically remote populations, gender and sexual minorities. In wake of the current COVID-19 pandemic, the need for WASH (Water, Sanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign will continue to raise awareness on the same along with focussing on the importance of nutrition and healthcare for women and children, fight malnutrition, mental wellbeing, self care, science and health, adolescent health & gender awareness. Along with the health of people, the campaign has realised the need to also take care of the health of the eco-system. Our environment is fragile due to human activity, that is not only over-exploiting available resources, but also generating immense pollution as a result of using and extracting those resources. The imbalance has also led to immense biodiversity loss that has caused one of the biggest threats to human survival – climate change. It has now been described as a “code red for humanity.” The campaign will continue to cover issues like air pollution, waste management, plastic ban, manual scavenging and sanitation workers and menstrual hygiene. Banega Swasth India will also be taking forward the dream of Swasth Bharat, the campaign feels that only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and the country can become a Swasth or healthy India.