- The study may have hints for targets for treatment: Experts
- Drugs targeting SR-B1 may help limit SARS-CoV-2 infection: Experts
- Coronavirus may use cells' cholesterol system to enhance infection: Study
Beijing: The SARS-CoV-2 virus, which causes COVID-19, may hijack our cells’ internal cholesterol processing system to help it spread through the body, according to a study which hints at new targets for a potential therapy against the disease. The cell culture study, published in the journal Nature Metabolism, identifies a potential molecular connection between cholesterol metabolism and COVID-19.
The researchers from the Academy of Military Medical Sciences (AMMS) in China found that the SARS-CoV-2 virus sticks to a receptor on the human cells that usually binds to HDL cholesterol, also known as ‘good’ cholesterol. When the scientists blocked the cholesterol receptor in the cells, the virus was no longer able to stick to them.
They say this hints at new targets for treatment, although this is very early-stage research. The study suggests that SARS-CoV-2 may use the cell’s internal cholesterol mechanisms to enhance infection. During SARS-CoV-2 infection, the spike protein on the virus binds a host-cell receptor called angiotensin-converting enzyme 2 (ACE2).
The researchers highlight the role of another receptor, called HDL scavenger receptor B type 1 (SR-B1), which is expressed in several tissues, including human lung cells. This receptor usually binds high-density lipoprotein (HDL). However, in this study, the viral spike protein bound cholesterol, and expression of SR-B1 and the presence of HDL together helped the virus bind and enter ACE2-expressing cells.
The virus seems to hijack the cell’s cholesterol-uptake machinery to facilitate entry into host cells, but when the researchers blocked this pathway with a monoclonal antibody or a specific pharmacological antagonist of SR-B1, the HDL-mediated enhancement of viral infection was absent. They conclude that the study highlights a potential molecular connection between COVID-19 and cholesterol, and they suggest that drugs targeting SR-B1 may help limit SARS-CoV-2 infection.
(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)
NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (Water, Sanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollution, waste management, plastic ban, manual scavenging and sanitation workers and menstrual hygiene.[corona_data_new]