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Double Mutation Found In 61 Per Cent Of 361 COVID-19 Samples: Expert

A senior genome sequencing expert, the sample collection has to be random and added that the double mutation was found in all samples from a particular set of samples sent from Nashik

Double Mutation Found In 61 Per Cent Of 361 COVID-19 Samples: Expert
  • Maharashtra is witnessing an unprecedented spike in cases
  • Maharashtra is the worst affected state in the country: Center
  • Maharashtra had 5,93,042 active cases as of Tuesday (April 13)

Mumbai: Double mutation has been detected in 61 per cent of the total 361 COVID-19 samples tested between January and March this year, a genome sequencing expert claimed on Wednesday (April 4) even as he raised doubts over the methods of sample collection being adopted by authorities in Maharashtra, which is worst affected by the pandemic. However, experts in the fields of genome sequencing and cell science have observed that such a small sample size cannot be considered as an indication of the spread of the mutated virus.

Also Read: One COVID-19 Patient Can Infect 400 People: Maharashtra Health Official

These 361 samples were tested at the genome sequencing laboratories in Maharashtra. On the other hand, authorities and officials of civic bodies that are collecting COVID-19 samples daily have complained about the lack of communication from the genome sequencing laboratories in Maharashtra as well as from the Centre about their findings on the sample analysis.

This lack of communication is resulting in civic bodies and state health officials remaining in the dark and thus unable to come up with a better strategy to curb the rapid spread of coronavirus in Maharashtra, they said.

I am told that out of 361 COVID-19 samples tested by the National Institute of Virology in Pune, 61 per cent had the double mutation. However, this sample size is too small to conclude as Maharashtra has been conducting nearly two lakh tests per day. One should not take such a small sample size as an indication that the mutated virus is widespread, a senior genome sequencing expert told PTI.

Maharashtra is witnessing an unprecedented spike in coronavirus positive cases for the last few weeks. As of Tuesday, the cumulative tally of the infections in Maharashtra, the worst-hit state in India, stood at35,19,208 while the death toll stood at 58,526, as per the state health department.

Maharashtra had 5,93,042 active cases as of Tuesday.

Concerns were raised recently about the methods of sample collection being adopted by civic bodies and local health officials who are conducting daily COVID-19 tests, the expert said.

Stressing that the sample collection has to be random, he said the double mutation was found in all samples from a particular set of samples sent from Nashik.

Some 10 samples were sent from Nashik. When we inquired about the method used in collecting these samples, we found that local officials had sent 10 consecutive samples for genome sequencing. The sample selection has to be random to assess where exactly the mutated virus is found, he said.

In the case of Nashik, it means that these samples could be of the members of a big joint family

Also Read: Maharashtra Government Aims To Vaccinate 3 Lakh People Per Day: Health Minister Rajesh Tope

Another possibility is that the people could be from the same area. (sample collection which is done in such a manner) completely defeats the purpose of random sampling and the genome sequencing efforts, he added.

The expert PTI spoke to works with a genome sequencing laboratory. Genome sequencing is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism’s genome at a single time.

Brihanmumbai Municipal Corporation (BMC) Additional Commissioner Suresh Kakani said that samples are being sent regularly to genome sequencing laboratories, “but we are not receiving any communication from them”.

We still do not know whether the sent samples contain the double mutation of the novel coronavirus or whether it is the earlier variant. If genome sequencing identifies the presence of double mutant virus (technically known as B.1.617) in the samples, in that event, we can issue revised guidelines to minimise its spread as it is more infectious, Mr. Kakani said.

He said the need of the hour is a regular update from the Centre or the consortium of ten laboratories set up for genome sequencing (by the Union government). Known as the “Indian SARS-CoV-2 Consortium on Genomics (INSACOG), it has identified two important mutations in the coronavirus variant dubbed as a “double mutant”. So far, the double mutant has been reported in various countries.

Meanwhile, another senior scientist in the field of genomic sequencing claimed the consortium is still not fully operational “as there is a huge communication gap among the member laboratories”.

Unless the communication is smooth, it will take a longer time for the state machinery to know whether they are dealing with an old variant of COVID-19 or an infectious one. We are lucky that the virus is not mutated yet and not become lethal. We cannot afford to learn about the status of the virus so late due to the lack of communication between these laboratories that have a common goal of genome sequencing, he said.

Also Read: Maharashtra In Beginning Of Second COVID-19 Wave, Says Central Team Report

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

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