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ICMR Advises States To Conduct Sero-Survey To Measure Coronavirus Exposure In People Using IgG ELISA Test

The Indian Council of Medical Research has said that antibody IgG test is not useful for detecting acute infection but indicates an episode of SARS-CoV-2 infection in the past

ICMR Advises States To Conduct Sero-Survey To Measure Coronavirus Exposure In People Using IgG ELISA Test
  • Antibody tests are useful for detection after 5-7 days of illness: ICMR
  • There is a demand for different COVID-19 tests across the world: ICMR
  • ICMR has offered to provide support to states in carrying of sero-surveys

New Delhi: The Indian Council of Medical Research (ICMR) on Saturday advised States to conduct sero-survey to measure coronavirus exposure in the population using IgG ELISA Test. The ICMR said, “The COVID19 pandemic has so far affected 216 countries and caused more than 59.31 lakh cases and 3.65 lakh deaths worldwide. There is a continuous demand for various types of diagnostic tests by countries all across the globe.”

Also Read: BMC’s Revised Guidelines For COVID-19 Testing: Pregnant Women Likely To Deliver In Next 5 Days To Be Tested

The ICMR said that Real-time i.e. RT-PCR test is considered gold standard frontline test for clinical diagnosis of SARS-CoV-2, causing COVID19. The test is useful only when performed in the acute stage of infection (< 7 days). For several viral infections, antibody tests are useful for disease detection after 5-7 days of illness. Understanding related to antibody tests for COVID19 is evolving and several tests are being developed globally. The ICMR said,

IgG antibodies generally start appearing after two weeks of onset of infection, once the individual has recovered after infection and last for several months. Therefore, the IgG test is not useful for detecting acute infection but indicates episode of SARS-CoV-2 infection in the past. However, detection of IgG antibodies is useful in the following situations: Sero-surveys help to understand the proportion of the population exposed to SARS-CoV-2 infection including asymptomatic individuals. Depending upon the level of sero-prevalence of infection, appropriate public health interventions can be planned and implemented for prevention and control of the disease. Periodic sero-surveys are useful to guide the policy makers. Survey in high risk or vulnerable populations (health care workers, frontline workers, immune-compromised individuals, individuals in containment zones, etc.) to know who has been infected in the past and has now recovered.

It further said that in an attempt to decide the future course of action against the pandemic, ICMR has communicated a detailed plan to all the states to measure coronavirus exposure in general population as well as in high risk populations. This sero-survey will guide appropriate public health intervention. An indicative list of different groups has been provided for adequate representation (Annexure I). The numbers and frequency in different groups to be tested has been entrusted with states depending upon the requirement and situation in that particular area.

Also Read: Quick, Cheap RT-Lamp COVID-19 Test Will Cost Up To Rs. 200, Take Less Than An Hour To Give Result: CSIR

The Annexure I given by ICMR include possible groups/ community/ population based on specific requirement for sero-survey by using IgG Elisa test. The ICMR said,

The sero-survey would be conducted using an IgG ELISA kit. Scientists at ICMR-National Institute of Virology, Pune have developed and validated an indigenous IgG ELISA test for antibody detection for SARS-CoV-2. The test has undergone intense validation in three stages and has been found to have high sensitivity and specificity.

To fast track production and increase availability of the IgG ELISA test, ICMR has transferred this technology to many pharma companies viz. Zydus Cadila, J Mitra & Company, Meril Diagnostics, Voxtur Bio, Trivitron Healthcare, Karwah Enterprises, Avecon Healthcare, etc.

The technology has been transferred to various entities without exclusivity clause and therefore can be further shared with others as per demand and capability. IgG ELISA tests from other USFDA/ CE-IVD/ indigenous sources are also available.

ICMR has offered to provide technical support to States/ UTs, if required, in planning and carrying out sero-surveys using IgG Elisa test kits and also interpreting the results.

Also Read: India Testing 1.1 Lakh COVID-19 Samples In A Day: ICMR Chief

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