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Latest Discovery Provides Hope For Early Detection Of Serious COVID-19

The researchers from QIMR Berghofer Medical Research Institute hope the discovery could be used to identify early on which patients’ immune systems are not responding appropriately, and who might be at higher risk of becoming seriously unwell

Latest Discovery Provides Hope For Early Detection Of Serious COVID-19
Highlights
  • T cells are the immune cells that destroy cells infected with SARS-CoV-2
  • T cells produce signalling molecules when they fight viruses: Researcher
  • The study is published in the journal Clinical and Translational Immunology

Brisbane: Australian researchers have developed a way of testing whether or not COVID-19 patients’ immune systems are gearing up to fight the virus that causes the deadly disease. The researchers from QIMR Berghofer Medical Research Institute hope the discovery could be used to identify early on which patients’ immune systems are not responding appropriately, and who might be at higher risk of becoming seriously unwell. The prototype test detects high levels of two key chemical signals that are produced by T cells when they recognise SARS-CoV-2-infected cells and start to fight the infection. SARS-CoV-2 is a virus that causes COVID-19.

Also Read: Antibodies In Mucous Membrane May Dominate Early COVID-19 Immune Response: Study

T cells are the immune cells that recognise and destroy cells infected with SARS-CoV-2. Study leader and the head of QIMR Berghofer’s Translational and Human Immunology Group, Associate Professor Corey Smith, said the researchers examined blood donated by 44 Queenslanders who had recovered from COVID-19 to find out which combination of viral peptides could be used to stimulate T cells in the laboratory and allow researchers to measure their response to SARS-CoV-2.

T cells produce a range of signalling molecules when they fight viruses, Associate Professor Corey Smith said.

Also Read: COVID-19: ‘Don’t Hug’ Is World Health Organisation’s Advice For The Holidays

These signalling molecules are basically indicators of whether T cells are responding to the SARS-CoV-2 virus and are mobilising the immune army to launch an attack. If we can find a way to detect whether or not they are present, then we can find out whether or not a patient’s immune system is responding as it should, Corey Smith added.

We isolated the T cells from the donated blood, exposed them to viral peptides, and measured the production of a number of different signalling molecules. We then compared the levels produced by T cells from the recovered COVID-19 patients with levels released by T cells from 20 healthy donors who had never been infected with SARS-CoV-2, said Corey Smith.

Also Read: World Health Organisation Says Almost All COVID-19 Cases Develop Immune Response

The researchers found that T cells from people who had recovered from COVID-19 produced larger amounts of the signalling molecules interferon-gamma and interleukin-2, which are involved in killing virus-infected cells and encouraging other T cells to come to the infected area.

Details of the study have been published on Monday (December 7) in the journal Clinical and Translational Immunology.

Also Read: New Smartphone-Based COVID-19 Test Gives Results In Less Than 30 Minutes

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

26,43,68,460Cases
22,50,84,762Active
3,40,45,666Recovered
52,38,032Deaths
Coronavirus has spread to 196 countries. The total confirmed cases worldwide are 26,43,68,460 and 52,38,032 have died; 22,50,84,762 are active cases and 3,40,45,666 have recovered as on December 3, 2021 at 1:36 pm.

India

3,46,15,757 9,216Cases
99,976 213Active
3,40,45,666 8,612Recovered
4,70,115 391Deaths
In India, there are 3,46,15,757 confirmed cases including 4,70,115 deaths. The number of active cases is 99,976 and 3,40,45,666 have recovered as on December 3, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

66,37,221 796

10,882 180

64,85,290 952

1,41,049 24

Kerala

51,51,919 4,700

45,030 252

50,66,034 4,128

40,855 320

Karnataka

29,96,833 363

6,772 169

29,51,845 191

38,216 3

Tamil Nadu

27,28,350 715

8,155 45

26,83,691 748

36,504 12

Andhra Pradesh

20,73,252 159

2,138 11

20,56,670 169

14,444 1

Uttar Pradesh

17,10,417 12

93 1

16,87,413 11

22,911

West Bengal

16,17,408 657

7,690 22

15,90,208 667

19,510 12

Delhi

14,41,190 217

307 21

14,15,785 196

25,098

Odisha

10,49,597 252

2,211 26

10,38,971 276

8,415 2

Chhattisgarh

10,06,870 37

328 12

9,92,949 25

13,593

Rajasthan

9,54,827 21

213 10

9,45,659 11

8,955

Gujarat

8,27,570 50

318 25

8,17,158 24

10,094 1

Madhya Pradesh

7,93,199 12

128 4

7,82,543 8

10,528

Haryana

7,71,760 27

178 9

7,61,528 18

10,054

Bihar

7,26,230 5

32 0

7,16,534 4

9,664 1

Telangana

6,76,376 189

3,680 50

6,68,701 137

3,995 2

Assam

6,17,163 124

2,535 77

6,08,517 198

6,111 3

Punjab

6,03,352 32

344 13

5,86,402 18

16,606 1

Jharkhand

3,49,271 15

95 1

3,44,035 13

5,141 1

Uttarakhand

3,44,325 22

182 4

3,36,735 18

7,408

Jammu And Kashmir

3,37,263 177

1,697 10

3,31,089 167

4,477

Himachal Pradesh

2,27,354 85

835 29

2,22,669 113

3,850 1

Goa

1,79,046 56

367 40

1,75,295 16

3,384

Mizoram

1,35,765 315

3,717 55

1,31,545 368

503 2

Puducherry

1,28,998 33

299 10

1,26,826 23

1,873

Manipur

1,25,269 33

663 4

1,22,627 28

1,979 1

Tripura

84,835 15

94 6

83,916 8

825 1

Meghalaya

84,534 24

296 2

82,764 25

1,474 1

Chandigarh

65,475 4

65 1

64,590 5

820

Arunachal Pradesh

55,285 6

36 1

54,969 5

280

Sikkim

32,267 15

137 10

31,727 5

403

Nagaland

32,128 3

128 5

31,302 6

698 2

Ladakh

21,642 41

306 21

21,122 20

214

Dadra And Nagar Haveli

10,683

0 1

10,679 1

4

Lakshadweep

10,397 1

18 8

10,328 9

51

Andaman And Nicobar Islands

7,686 3

7 2

7,550 1

129

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