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National Task Force And Joint Monitoring Group Will Decide On Continuing Plasma Therapy For COVID Treatment: ICMR

Presently, Convalescent Plasma is used for the treatment of COVID-19 patients with the moderate disease who are not improving (oxygen requirement is progressively increasing) despite the use of steroids

National Task Force And Joint Monitoring Group Will Decide On Continuing Plasma Therapy For COVID Treatment: ICMR
Highlights
  • Plasma therapy has been used for over 100 years for various virus infection
  • It was used in Ebola and now being tried in treating COVID-19 patients
  • Plasma therapy didn't help in reducing deaths due to COVID-19: ICMR study

New Delhi: The National Task Force on COVID-19 and joint monitoring group (JMG) of the Health Ministry will decide whether the plasma therapy should be continued in the treatment of coronavirus infected patients in India, Professor (Dr.) Balram Bhargava, Director General of Indian Council of Medical Research (ICMR) on Tuesday (September 15). Dr Bhargava informed in context with the ICMR findings that revealed Convalescent Plasma (CP) therapy didn’t help in reducing death due to the coronavirus in India.

Also Read: Convalescent Plasma Therapy Cannot Be Given To Everyone, May Be Useful In Early Stage Of COVID-19: AIIMS Director

Plasma therapy has been used for more than 100 years now in some form or the other for various virus infections. It was used in ebola and now being COVID-19. Whether it helps in coronavirus treatment or not, it is being studied. It is still undergoing peer review, he said during a press conference here.

“Once peer review happens and we get a full publication out, this data will be considered again by the National Task Force and joint monitoring group of Health Ministry, then a decision will be taken if we should continue with it,” he said when asked to comment upon the recent ICMR study stating Convalescent Plasma (CP) therapy did not help in reducing death due to the coronavirus.

Presently, Convalescent Plasma is in the-off label use in patients with moderate disease who are not improving (oxygen requirement is progressively increasing) despite the use of steroids.

India has also contributed internationally by randomized trials on 464 patients in 39 hospitals in 25 districts across 14 states and Union Territories. Trials have shown that it does not reduce mortality or prevent progression from moderate to severe disease, Dr. Bhargava said.

Also Read: Convalescent Plasma Therapy Didn’t Help In Reducing COVID-19 Deaths: ICMR Study

It may be noted that the apex medical research has made these revelations to investigate the effectiveness of plasma therapy for the treatment of COVID-19 after conducting a study in 39 hospitals across India.

According to medical experts, bodies of people who recover from coronavirus produce an anti-body/plasma in the blood to help the person fight against coronavirus. If a little bit of this anti-body/plasma is given to a critical patient then the plasma helps in the latter person’s recovery.

The ICMR researchers did an open-label, parallel-arm, phase II, multicentre, and randomized controlled trial from April 22 to July 14. The trial was registered with the Clinical Trial Registry of India (CTRI) for the purpose, it said.

The study was conducted between April 22 to July 14 in 464 participants who were hospitalized and moderately ill confirmed COVID-19 patients. About 464 patients were randomly enrolled. About 235 participants were put in the intervention arm while 229 subjects were in the control arm.

Also Read: Initial Findings On Plasma Therapy Trial Did Not Show Promising Evidence: AIIMS

According to the study, participants were randomized to either control or intervention arm. Two doses of 200 ml CP were transfused 24 hours apart in the intervention arm, the study noted.

Composite primary outcome was achieved in 44 (18.7 percent) participants in the intervention arm and 41 (17.9 percent) in the control arm. Mortality was documented in 34 (13.6 percent) and 31 (14.6 percent) participants in intervention and control arm, respectively, study mentioned.

“Convalescent plasma was not associated with a reduction in mortality or progression to severe COVID-19. This trial has high generalizability and approximates the real-life setting of convalescent plasma therapy in settings with limited laboratory capacity. A prior measurement of neutralizing antibody titres in donors and participants may further clarify the role of CP in the management of COVID-19,” concluded the findings of the study.

Meanwhile, India’s COVID-19 case tally crossed the 49-lakh mark today. A total of 49,30,237 cases have been reported in the country including 9,90,061 active cases, 38,59,400 cured/discharged/migrated and 80,776 deaths.

Also Read: COVID-19: Muted Response To Plasma Donation Call, Doctors Say Unfounded Fears Keeping People Away

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.) 

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World

22,90,75,864Cases
19,16,26,474Active
3,27,49,574Recovered
46,99,816Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 22,90,75,864 and 46,99,816 have died; 19,16,26,474 are active cases and 3,27,49,574 have recovered as on September 21, 2021 at 3:56 am.

India

3,35,04,534 26,115Cases
3,09,5758,606Active
3,27,49,574 34,469Recovered
4,45,385 252Deaths
In India, there are 3,35,04,534 confirmed cases including 4,45,385 deaths. The number of active cases is 3,09,575 and 3,27,49,574 have recovered as on September 21, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,24,498 2,583

45,229 1,281

63,40,723 3,836

1,38,546 28

Kerala

45,24,158 15,692

1,67,578 6,623

43,32,897 22,223

23,683 92

Karnataka

29,68,543 677

14,386 1,025

29,16,530 1,678

37,627 24

Tamil Nadu

26,47,041 1,661

16,984 15

25,94,697 1,623

35,360 23

Andhra Pradesh

20,39,529 839

14,388 311

20,11,063 1,142

14,078 8

Uttar Pradesh

17,09,680 11

194 4

16,86,599 15

22,887

West Bengal

15,62,173 524

7,810 96

15,35,699 608

18,664 12

Delhi

14,38,517 20

379 8

14,13,053 28

25,085

Odisha

10,20,754 510

4,947 96

10,07,666 600

8,141 6

Chhattisgarh

10,05,094 38

297 7

9,91,234 43

13,563 2

Rajasthan

9,54,263 9

91 10

9,45,218 19

8,954

Gujarat

8,25,737 14

133 3

8,15,522 17

10,082

Madhya Pradesh

7,92,402 8

96 0

7,81,789 8

10,517

Haryana

7,70,746 13

340 6

7,60,598 7

9,808

Bihar

7,25,901 7

69 1

7,16,173 8

9,659

Telangana

6,63,662 208

4,991 14

6,54,765 220

3,906 2

Punjab

6,01,323 59

307 10

5,84,517 38

16,499 31

Assam

5,98,423 455

4,984 72

5,87,632 517

5,807 10

Jharkhand

3,48,125 9

55 1

3,42,937 10

5,133

Uttarakhand

3,43,393 11

267 6

3,35,736 17

7,390

Jammu And Kashmir

3,28,069 128

1,461 32

3,22,191 159

4,417 1

Himachal Pradesh

2,17,140 234

1,616 54

2,11,871 177

3,653 3

Goa

1,75,583 85

810 36

1,71,478 48

3,295 1

Puducherry

1,25,517 54

867 56

1,22,818 109

1,832 1

Manipur

1,18,673 178

2,183 6

1,14,658 183

1,832 1

Tripura

83,905 51

346 10

82,750 40

809 1

Mizoram

81,460 1,731

15,140 1,008

66,057 721

263 2

Meghalaya

79,667 174

1,896 5

76,391 168

1,380 1

Chandigarh

65,188 7

41 4

64,329 3

818

Arunachal Pradesh

54,126 56

410 12

53,444 67

272 1

Sikkim

30,971 16

654 59

29,937 74

380 1

Nagaland

30,907 43

467 17

29,786 59

654 1

Ladakh

20,737 7

138 4

20,392 3

207

Dadra And Nagar Haveli

10,670

0 1

10,666 1

4

Lakshadweep

10,359 3

8 3

10,300

51

Andaman And Nicobar Islands

7,600

13 0

7,458

129

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