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Convalescent Plasma Therapy Didn’t Help In Reducing COVID-19 Deaths: ICMR Study

The India Council of Medical Research (ICMR) conducted a study to investigate the effectiveness of plasma therapy for the treatment of COVID-19 in 39 hospitals across India

Convalescent Plasma Therapy Didn't Help In Reducing COVID-19 Deaths: ICMR Study
Highlights
  • The study assessing plasma therapy was conducted on 464 participants
  • For the study, only 235 COVID patients were administered plasma
  • Mortality was documented in 13.6% participants who were given plasma

New Delhi: The Convalescent Plasma (CP) therapy didn’t help in reducing death due to the coronavirus, the India Council of Medical Research (ICMR) revealed in a study. The apex medical research has made these revelations to investigate the effectiveness of plasma therapy for the treatment of COVID-19 after conducting a study in 39 hospitals across India. For this, the ICMR researchers did an open-label, parallel-arm, phase II, multicentre, and randomized controlled trial from April 22 to July 14 this year. The trial was registered with the Clinical Trial Registry of India (CTRI) for the purpose, it said.

Also Read: Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

A total of 1,210 patients (moderately ill confirmed COVID-19) admitted across 39 trial sites were screened. Of these, 29 were teaching public hospitals and 10 were private hospitals spread across 14 states and Union Territories representing 25 cities.

The study was conducted on 464 participants who were hospitalized and moderately ill confirmed COVID-19 patients, and these 464 patients were randomly enrolled. Out of which, about 235 participants were put in the intervention arm while 229 subjects were in the control arm.

According to the study, participants were randomized to either control or intervention arm. Two doses of 200 ml CP was transfused 24 hours apart in the intervention arm.

Composite primary outcome was achieved in 44 (18.7 per cent) participants in the intervention arm and 41 (17.9 per cent) in the control arm. Mortality was documented in 34 (13.6 per cent) and 31 (14.6 per cent) participants in intervention and control arm, respectively, study mentioned.

“Convalescent Plasma was not associated with a reduction in mortality or progression to severe COVID-19. This trial has high generalizability and approximates real-life setting of convalescent plasma therapy in settings with limited laboratory capacity. A priori measurement of neutralizing antibody titres in donors and participants may further clarify the role of CP in the management of COVID-19,” concluded the findings of the study.

Also Read: COVID-19: Muted Response To Plasma Donation Call, Doctors Say Unfounded Fears Keeping People Away

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.) 

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene.  

World

24,20,23,922Cases
20,36,06,535Active
3,34,95,808Recovered
49,21,579Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 24,20,23,922 and 49,21,579 have died; 20,36,06,535 are active cases and 3,34,95,808 have recovered as on October 21, 2021 at 4:33 am.

India

3,41,27,450 18,454Cases
1,78,831 733Active
3,34,95,808 17,561Recovered
4,52,811 160Deaths
In India, there are 3,41,27,450 confirmed cases including 4,52,811 deaths. The number of active cases is 1,78,831 and 3,34,95,808 have recovered as on October 21, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,96,645 1,825

29,333 1,075

64,27,426 2,879

1,39,886 21

Kerala

48,79,790 11,150

83,333 2,476

47,69,373 8,592

27,084 82

Karnataka

29,84,484 462

9,103 26

29,37,405 479

37,976 9

Tamil Nadu

26,90,633 1,170

14,058 268

26,40,627 1,418

35,948 20

Andhra Pradesh

20,61,810 523

5,566 88

20,41,924 608

14,320 3

Uttar Pradesh

17,10,058 11

112 6

16,87,048 17

22,898

West Bengal

15,82,813 867

7,491 63

15,56,315 795

19,007 9

Delhi

14,39,466 25

310 12

14,14,066 37

25,090

Odisha

10,36,532 559

4,387 106

10,23,849 451

8,296 2

Chhattisgarh

10,05,735 34

185 3

9,91,979 36

13,571 1

Rajasthan

9,54,393 1

38 0

9,45,401 1

8,954

Gujarat

8,26,340 14

176 9

8,16,077 22

10,087 1

Madhya Pradesh

7,92,709 9

82 3

7,82,104 6

10,523

Haryana

7,71,116 15

133 7

7,60,934 8

10,049

Bihar

7,26,036 3

30 12

7,16,345 15

9,661

Telangana

6,69,556 191

3,968 28

6,61,646 162

3,942 1

Assam

6,07,427 308

3,610 25

5,97,859 282

5,958 1

Punjab

6,02,113 32

232 16

5,85,331 15

16,550 1

Jharkhand

3,48,486 25

142 14

3,43,209 11

5,135

Uttarakhand

3,43,773 8

176 1

3,36,199 6

7,398 1

Jammu And Kashmir

3,31,299 78

800 3

3,26,070 80

4,429 1

Himachal Pradesh

2,21,936 110

1,394 46

2,16,815 64

3,727

Goa

1,77,706 47

597 23

1,73,755 70

3,354

Puducherry

1,27,521 42

461 29

1,25,208 71

1,852

Manipur

1,22,970 71

1,360 2

1,19,706 66

1,904 3

Mizoram

1,15,207 741

10,263 505

1,04,548 1,243

396 3

Tripura

84,351 2

95 7

83,440 9

816

Meghalaya

83,158 79

761 21

80,958 58

1,439

Chandigarh

65,312 2

24 1

64,468 3

820

Arunachal Pradesh

55,043 12

138 7

54,625 19

280

Sikkim

31,800 17

175 6

31,232 22

393 1

Nagaland

31,659 18

255 8

30,728 10

676

Ladakh

20,886 3

34 0

20,644 3

208

Dadra And Nagar Haveli

10,676

2 2

10,670 2

4

Lakshadweep

10,365

0 0

10,314

51

Andaman And Nicobar Islands

7,646

7 1

7,510 1

129

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