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Antibodies Found To Be More Potent During Recovery Than During Acute Chikungunya Infection: Study

Chikungunya, a mosquito-borne viral disease caused by the chikungunya virus, is characterised by fever and joint pain and is a global public health threat

Antibodies Found To Be More Potent During Recovery Than During Acute Chikungunya Infection, Lancet Study Finds
The researchers collected 196 acute Chikungunya patients and 51 paired serum samples (acute and one-month follow-up) from lab-confirmed infections between 2016 and 2021

New Delhi: Potency of antibodies generated against Chikungunya infection was higher during patients’ recovery phase than that during their acute infection phase, according to a new study published in The Lancet Regional Health-Southeast Asia journal. The findings are crucial in understanding disease dynamics at a given point in time, the study from Indian institutes including AIIMS-Bhubaneswar, Manipal Institute of Virology, Karnataka, and International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, said.

Even though the antibodies were produced as a result of the viral infection, serological analysis indicated that the neutralising capacity of blood serum antibodies of Chikungunya patients during their recovery phase was higher than that during acute infection, it said.

Chikungunya disease (CHIKD), a mosquito-borne viral disease caused by the Chikungunya virus, is characterised by fever and joint pain and is a global public health threat. Patients may also go on to develop headache, muscle pain, joint swelling, or rash.

Also Read: Chikungunya Virus’s ‘Invisibility Shield’ May Lead To Vaccines Or Treatments: Study 

The present study was conducted as part of two consortia involving thirteen clinical sites across India, that included healthcare centres in Tamil Nadu, Karnataka, Tripura, Assam and other states.

The researchers collected 196 acute Chikungunya patients and 51 paired serum samples (acute and one-month follow-up) from lab-confirmed infections between 2016 and 2021. “Acute samples” were those collected in the first two weeks following symptom onset and “convalescent samples” were those collected a month after.

Other clinical-epidemiological data such as age, gender, temperature, Clinical Disease Activity Index (CDAI) score for assessing disease severity and progression, along with symptoms, co-morbidities, complete blood count and travel history were also collected via questionnaires.

The serum samples were profiled for cytokines, proteins involved in regulating the body’s immune and inflammation response, and neutralisation capacity.

The neutralising capacity of the blood serum antibodies was significantly higher in convalescent samples compared to acute samples, the researchers found.

The frequently observed clinical features during the first two weeks of the infection included joint pain (91.84 per cent), muscle pain (90.82 per cent), headache (92.35 per cent) and morning stiffness (56.47 per cent), the researchers said in the study.

Other less frequently observed symptoms recorded were eye infections and pain, nausea, abdominal pain rashes, cough, photophobia or fear of light, diarrhoea, vomiting, oedema, they said.

Also Read: Scientists Identify Drug Target For Multiple Mosquito-Transmitted Viruses

Further, 74 per cent of patients exhibiting severe disease at the time of collection of first sample converted to persistent arthralgia, or joint pain, the researchers found by interviewing these patients. However, in the remaining patients the symptoms appeared to be resolved, they said.

(This story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol have been working towards a clean and healthy India since 2014 via the Banega Swachh India initiative, which is helmed by Campaign Ambassador Amitabh Bachchan. The campaign aims to highlight the inter-dependency of humans and the environment, and of humans on one another with the focus on One Health, One Planet, One Future – Leaving No One Behind. It stresses on the need to take care of, and consider, everyone’s health in India – especially vulnerable communities – theLGBTQ population,indigenous people, India’s different tribes, ethnic and linguistic minorities, people with disabilities, migrants, geographically remote populations, gender and sexual minorities. In wake of the currentCOVID-19 pandemic, the need for WASH (Water,SanitationandHygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign will continue to raise awareness on the same along with focussing on the importance of nutrition and healthcare for women and children, fightmalnutrition, mental wellbeing, self care, science and health,adolescent health & gender awareness. Along with the health of people, the campaign has realised the need to also take care of the health of the eco-system. Our environment is fragile due to human activity, which is not only over-exploiting available resources, but also generating immense pollution as a result of using and extracting those resources. The imbalance has also led to immense biodiversity loss that has caused one of the biggest threats to human survival – climate change. It has now been described as a “code red for humanity.” The campaign will continue to cover issues likeair pollution,waste management,plastic ban,manual scavengingand sanitation workers andmenstrual hygiene. Banega Swasth India will also be taking forward the dream of Swasth Bharat, the campaign feels that only a Swachh or clean India wheretoiletsare used andopen defecation free (ODF)status achieved as part of the Swachh Bharat Abhiyan launched byPrime Minister Narendra Modiin 2014, can eradicate diseases like diahorrea and the country can become a Swasth or healthy India.

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