Connect with us

Coronavirus Outbreak

COVID-19 ICU Patients At Risk Of Acute Brain Dysfunction, Says Study

Nearly 82 per cent of the COVID-19 patients in the study were in coma stage for an average of 10 days, and 55 per cent were delirious for an average of three days

COVID-19 ICU Patients At Risk Of Acute Brain Dysfunction, Says Study
Highlights
  • Experts noted that acute brain dysfunction lasted for an average of 12 days
  • ICU delirium is associated with higher risk of death: Scientists
  • 2,000 COVID-19 patients were observed for conducting the study

New Delhi: COVID-19 patients admitted to intensive care in the early months of the pandemic experienced a higher burden of delirium and coma than is typically found in those hospitalised with acute respiratory failure, according to the largest study of its kind to date. The research, published in The Lancet Respiratory Medicine journal, tracked the incidence of delirium and coma in over 2,000 COVID-19 patients admitted before April 28, 2020, to 69 adult intensive care units across 14 countries.

Also Read: As India Gears Up To Kick-starts COVID-19 Vaccination Drive From January 16, Expert Explains When Will The Common Man Get The Vaccine

According to the scientists, led by those at Vanderbilt University Medical Center in the US, the choice of sedative medications and curbs on family visitation played a role in increasing acute brain dysfunction for these patients. They said ICU delirium is associated with higher medical costs and greater risk of death and long-term ICU-related dementia.

Nearly 82 per cent of the patients in the study were comatose for a median of 10 days, and 55 per cent were delirious for a median of three days. The scientists noted that acute brain dysfunction lasted for an average of 12 days. “This is double what is seen in non-COVID ICU patients,” said study co-author Brenda Pun from VUMC.

The scientists believe COVID-19 could predispose patients to a higher burden of acute brain dysfunction. However, they also noted that patient care factors, some of which are related to pressures posed on health care by the pandemic, also appear to have played a significant role.

Also Read: COVID-19 Vaccination To Start In India On Jan 16; 3 Crore Healthcare, Frontline Workers To Get Shots First

With respect to COVID-19, the scientists believe there has been widespread abandonment of newer clinical protocols that are proven to help ward off the acute brain dysfunction that usually affects many critically ill patients.

It is clear in our findings that many ICUs reverted to sedation practices that are not in line with best practice guidelines and we’re left to speculate on the causes. Early reports of COVID-19 suggested that the lung dysfunction seen required unique management techniques including deep sedation. In the process, key preventive measures against acute brain dysfunction went somewhat by the boards, Ms. Pun said.

Analysing patient characteristics from electronic health records, and care practices and findings from clinical assessments, the scientists found that about 90 per cent of patients tracked in the study were invasively mechanical ventilated at some point during hospitalisation, and 67 per cent on the day of ICU admission. Patients receiving benzodiazepine sedative infusions were at 59 per cent higher risk of developing delirium, they added. In comparison, the patients who received family visitation were at 30 per cent lower risk of delirium, the study noted.

There’s no reason to think that, since the close of our study, the situation for these patients has changed. These prolonged periods of acute brain dysfunction are largely avoidable. ICU teams need above all to return to lighter levels of sedation for these patients, frequent awakening and breathing trials, mobilisation and safe in-person or virtual visitation, said study senior author, Pratik Pandharipande.

Also Read: Amid Short Supplies, Vaccine Doses Can Be Six Weeks Apart, Says WHO

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

24,50,12,529Cases
20,64,25,824Active
3,36,14,434Recovered
49,72,271Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 24,50,12,529 and 49,72,271 have died; 20,64,25,824 are active cases and 3,36,14,434 have recovered as on October 28, 2021 at 4:00 am.

India

3,42,31,809 16,156Cases
1,60,9891,672Active
3,36,14,434 17,095Recovered
4,56,386 733Deaths
In India, there are 3,42,31,809 confirmed cases including 4,56,386 deaths. The number of active cases is 1,60,989 and 3,36,14,434 have recovered as on October 28, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

66,06,536 1,485

23,096 3,500

64,43,342 4,947

1,40,098 38

Kerala

49,38,603 9,445

77,158 2,100

48,31,468 6,723

29,977 622

Karnataka

29,86,835 282

8,459 80

29,40,339 349

38,037 13

Tamil Nadu

26,98,493 1,075

12,288 252

26,50,145 1,315

36,060 12

Andhra Pradesh

20,64,854 567

4,777 122

20,45,713 437

14,364 8

Uttar Pradesh

17,10,114 13

100 6

16,87,115 7

22,899

West Bengal

15,89,042 976

7,973 124

15,61,973 837

19,096 15

Delhi

14,39,709 38

348 25

14,14,270 13

25,091

Odisha

10,39,818 549

4,392 213

10,27,108 334

8,318 2

Chhattisgarh

10,05,926 28

263 14

9,92,088 12

13,575 2

Rajasthan

9,54,411 4

20 0

9,45,437 4

8,954

Gujarat

8,26,481 17

173 2

8,16,220 15

10,088

Madhya Pradesh

7,92,804 20

108 9

7,82,172 10

10,524 1

Haryana

7,71,204 15

133 5

7,61,022 10

10,049

Bihar

7,26,073 5

41 1

7,16,371 4

9,661

Telangana

6,70,829 186

4,164 63

6,62,714 122

3,951 1

Assam

6,09,506 244

3,838 153

5,99,681 391

5,987 6

Punjab

6,02,289 38

246 20

5,85,487 16

16,556 2

Jharkhand

3,48,705 28

160 30

3,43,408 56

5,137 2

Uttarakhand

3,43,861 17

150 6

3,36,312 23

7,399

Jammu And Kashmir

3,31,865 70

838 16

3,26,596 86

4,431

Himachal Pradesh

2,23,406 261

1,972 211

2,17,693 48

3,741 2

Goa

1,77,969 23

454 29

1,74,152 51

3,363 1

Puducherry

1,27,846 40

443 10

1,25,546 50

1,857

Manipur

1,23,473 70

844 29

1,20,712 97

1,917 2

Mizoram

1,19,496 547

7,320 446

1,11,752 991

424 2

Tripura

84,438 15

123 1

83,499 14

816

Meghalaya

83,466 51

507 22

81,511 71

1,448 2

Chandigarh

65,331 5

29 2

64,482 3

820

Arunachal Pradesh

55,120 6

115 22

54,725 28

280

Sikkim

31,925 13

177 1

31,353 12

395

Nagaland

31,759 12

222 3

30,856 15

681

Ladakh

20,925 8

47 6

20,670 2

208

Dadra And Nagar Haveli

10,682 1

6 0

10,672 1

4

Lakshadweep

10,365

0 0

10,314

51

Andaman And Nicobar Islands

7,650 2

5 1

7,516 1

129

Coronavirus Outbreak: Full CoverageTesting CentresFAQs

Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Highlights From The 12-Hour Telethon

Leaving No One Behind

Mental Health

Environment

Join Us