COVID-19: Indiscriminate Use Of Convalescent Plasma Therapy Not Advisable, Says ICMR

COVID-19: Indiscriminate Use Of Convalescent Plasma Therapy Not Advisable, Says ICMR

The Indian Council of Medical Research (ICMR) has asked to avoid the indiscriminate use of Convalescent Plasma Therapy (CPT) as it does not reduce mortality in COVID-19 patients
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COVID-19: Indiscriminate Use Of Convalescent Plasma Therapy Not Advisable, Says ICMRThe Indian Council of Medical Research (ICMR) said plasma therapy should be administered between 3-7 days from onset of symptoms
Highlights
  • ICMR has advised states to desist indiscriminate use of plasma therapy
  • ICMR issued Standard Operating Procedure on plasma therapy
  • An individual can donate plasma after 14 days of symptom resolution: ICMR

New Delhi: The country’s top medical research body–India Council of Medical Research (ICMR) on Wednesday (November 18) said that indiscriminate use of Convalescent Plasma Therapy (CPT) should be avoided as it does not reduce mortality in COVID-19 patients. The apex medical research body issued Standard Operating Procedure (SoP) on plasma therapy and advised states to desist from its indiscriminate use. “ICMR conducted an open-label phase II multicentre randomised controlled trial in India across 39 public and private hospitals on use of convalescent plasma in the management of cases with moderate COVID-19 disease (PLACID Trial). It was concluded that, CPT did not lead to reduction in progression to severe COVID19 or all cause mortality in the group that received CPT as compared to the group that did not receive CPT,” said the ICMR in its new advisory.

Also Read: Convalescent Plasma Therapy Didn’t Help In Reducing COVID-19 Deaths: ICMR Study

PLACID is the world’s largest pragmatic trial on CPT conducted in 464 moderately ill laboratory confirmed COVID-19 affected adults in real-world setting wherein no benefit of use of CPT could be established, it said.

The ICMR also mentioned that similar studies conducted in China and the Netherlands have also documented no significant benefit of CPT in improving the clinical outcomes of hospitalised COVID-19 patients, hence indiscriminate use of CPT is not advisable.

It is speculated that convalescent plasma having low concentration of specific antibody against SARS-CoV-2 may be less beneficial for treating COVID-19 patients as compared to plasma with high concentration of such antibodies, said the guidance note.

“This ICMR advisory, therefore, embraces the principle that a potential donor for convalescent plasma should have sufficient concentration of antibody working against COVID19,” it added.

Also Read: Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

The ICMR’s advisory noted that a potential donor of CPT can be a male and female–who have never been pregnant can only donate plasma, it said. The donor should be in the age group of 18-65 years who after 14 days of symptom resolution — testing negative for COVID-19 is not necessary, can donate plasma.

For the potential recipient, the ICMR said that donor can be in the early stage of COVID-19 and the therapy should be administered between 3-7 days from onset of symptoms, but not later than 10 days. There should be no IgG antibody against COVID-19 by appropriate test and informed consent has to be taken.

Also Read: Haryana Health Minister Anil Vij Offers To Be ‘First Volunteer’ For Phase-III Trial Of Covaxin In The State

It also highlights that presence of antibodies against COVID-19 in a potential recipient makes transfusing convalescent plasma a futile intervention.

CPT, therefore, should only be used, as advised by ICMR NTF, for management of COVID-19 when specific criteria are fulfilled, it said.

The advisory came after Union Home Minister Amit Shah held a meeting to assess the COVID situation in Delhi wherein it was discussed to issue SoP for plasma therapy and plasma administration for treatment of COVID-19 patients immediately.

On 20 October, ICMR Chief Dr Balram Bhargava had said the government is planning to delete plasma therapy from the national treatment guidelines on COVID-19.

Also Read: Convalescent Plasma Therapy Cannot Be Given To Everyone, May Be Useful In Early Stage Of COVID-19: AIIMS Director

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

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World

17,91,56,496Cases
5,81,68,051Active
11,71,06,212Recovered
38,82,233Deaths
Coronavirus has spread to 193 countries. The total confirmed cases worldwide are 17,91,56,496 and 38,82,233 have died; 5,81,68,051 are active cases and 11,71,06,212 have recovered as on June 23, 2021 at 3:45 am.

India

3,00,28,709 50,848Cases
6,43,19419,327Active
2,89,94,855 68,817Recovered
3,90,660 1,358Deaths
In India, there are 3,00,28,709 confirmed cases including 3,90,660 deaths. The number of active cases is 6,43,194 and 2,89,94,855 have recovered as on June 23, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

59,87,521 8,470

1,26,468 1,055

57,42,258 9,043

1,18,795 482

Kerala

28,29,460 12,617

1,00,881 746

27,16,284 11,730

12,295 141

Karnataka

28,15,029 3,709

1,18,615 4,541

26,62,250 8,111

34,164 139

Tamil Nadu

24,36,819 6,895

56,886 4,443

23,48,353 11,144

31,580 194

Andhra Pradesh

18,57,352 4,169

53,880 4,260

17,91,056 8,376

12,416 53

Uttar Pradesh

17,04,678 202

3,910 253

16,78,486 397

22,282 58

West Bengal

14,85,438 1,852

22,508 232

14,45,493 2,037

17,437 47

Delhi

14,32,778 397

1,918 78

14,05,927 467

24,933 8

Chhattisgarh

9,91,653 482

8,007 557

9,70,244 1,032

13,402 7

Rajasthan

9,51,393 137

2,388 303

9,40,101 437

8,904 3

Odisha

8,83,490 2,957

30,859 1,240

8,48,960 4,159

3,671 38

Gujarat

8,22,620 135

5,159 480

8,07,424 612

10,037 3

Madhya Pradesh

7,89,415 65

1,707 273

7,78,902 318

8,806 20

Haryana

7,67,726 146

2,200 137

7,56,231 263

9,295 20

Bihar

7,20,207 268

2,811 206

7,07,833 468

9,563 6

Telangana

6,15,574 1,175

16,640 606

5,95,348 1,771

3,586 10

Punjab

5,93,063 405

5,968 509

5,71,207 880

15,888 34

Assam

4,88,179 2,869

32,975 350

4,50,924 2,482

4,280 37

Jharkhand

3,44,775 110

1,417 72

3,38,256 180

5,102 2

Uttarakhand

3,38,978 171

2,896 68

3,29,030 231

7,052 8

Jammu And Kashmir

3,12,584 428

7,181 578

3,01,134 999

4,269 7

Himachal Pradesh

2,00,791 188

2,276 132

1,95,062 315

3,453 5

Goa

1,64,957 303

2,920 146

1,59,029 438

3,008 11

Puducherry

1,15,364 284

3,214 150

1,10,423 433

1,727 1

Manipur

64,993 575

9,214 84

54,714 649

1,065 10

Tripura

63,140 395

3,747 163

58,735 554

658 4

Chandigarh

61,467 23

278 33

60,383 56

806

Meghalaya

45,976 421

4,273 77

40,915 341

788 3

Arunachal Pradesh

33,664 289

2,548 9

30,956 279

160 1

Nagaland

24,438 64

1,757 87

22,204 149

477 2

Ladakh

19,871 33

360 5

19,309 38

202

Sikkim

19,458 137

2,430 18

16,732 152

296 3

Mizoram

18,409 430

4,424 197

13,900 233

85

Dadra And Nagar Haveli

10,520 4

61 1

10,455 3

4

Lakshadweep

9,504 33

315 4

9,142 36

47 1

Andaman And Nicobar Islands

7,425 10

103 6

7,195 4

127

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