Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

Plasma Therapy is the transfusion of antibodies from a recovered coronavirus patient to a critical patient and is being looked upon as one of the potential treatments to minimise the COVID-19 deaths
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Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?For COVID-19, Convalescent Plasma therapy has been approved by the United States Food and Drug Administration (FDA)
Highlights
  • Plasma therapy has shown positive results in Delhi, Noida, among others
  • The plasma therapy has been used to treat diseases like Hepatitis B
  • One can donate 500 ml of plasma which can be given to 2 COVID-19 patients

New Delhi: On Monday (June 29), Chief Ministers of Delhi, Maharashtra and Haryana made big announcements with regard to plasma therapy. Delhi Chief Minister Arvind Kejriwal announced setting up of a plasma bank to facilitate availability of life-saving plasma. Chief Minister of Maharashtra Uddhav Thackeray inaugurated ‘Project PLATINA’ claimed to be the world’s largest convalescent plasma therapy (CPT) trial cum treatment of severe COVID-19 patients. After receiving approval from the Indian Council of Medical Research (ICMR), Haryana Health Minister Anil Vij announced that the state will start plasma therapy as a treatment. Plasma therapy has been gaining ground as a possible treatment for critically-ill COVID-19 patients.

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

Also Read: Battling Coronavirus: After Going Through A Traumatic Experience To Find A Plasma Donor, Two Childhood Friends Come Up With A Website

On June 17, Delhi Health Minister Satyendar Jain tested positive for Coronavirus. Over the next two days, his condition deteriorated and he had to be shifted from Rajiv Gandhi Super Speciality Hospital (RGSSH) in Delhi’s Dilshad Garden to a private facility, Max Hospital in Saket. Here he was administered plasma therapy after which his condition improved – the fever subsided and oxygen levels improved. Plasma Therapy involves transfusion of antibodies from someone who has recovered from COVID-19 (convalescent coronavirus patient) into a critical patient. The therapy is based on the principle that the blood of a recovered patient is rich in antibodies needed to combat COVID-19, as these Y shaped proteins produced by a human body is used by the immune system to identify and neutralise foreign objects such as bacteria and viruses. These antibodies are expected to help critical patients recover.

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

The effectiveness of plasma therapy has also got a stamp of approval from the Food and Drug Administration (FDA) of United States. Countries like China, South Korea are using this technique to save lives of people suffering from COVID-19. In a series of tweets, the ICMR backed the center and said that FDA has also viewed plasma therapy as an experimental therapy and there is no robust evidence to support it for routine therapy.

Delhi has also been trying the convalescent plasma therapy (CPT) to treat critically ill patients of COVID-19 for quite some time now and so far, the results have been encouraging. A 49-year-old COVID-19 patient admitted in Delhi’s Max Hospital in April was the first to receive the treatment and recover from it. Since then plasma therapy has been given to 84 COVID-19 patients and has been successful in 80 cases.

Also Read: Combating COVID-19: Patient Treated With Plasma Therapy In Delhi Recovers, Discharged

States like Delhi, Maharashtra had already got the approval from the centre to start a clinical trial of plasma enrichment technique on COVID-19 patients who are critically ill.

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

But there are concerns as well. On April 28, at the regular news briefing, Lav Agarwal, Joint Secretary, Ministry of Health, called the treatment ‘life-threatening’ and said,

There is no concrete evidence to support plasma therapy as coronavirus treatment. The therapy is still in an experimental stage and the ICMR is conducting a national study on it. It can even be life-threatening if not carefully done.

Back then Mr Agarwal very categorically stated that plasma therapy should be used only for research or trial purposes and should not be considered as an approved therapy for the treatment of COVID-19.

Also Read: Combating COVID-19: Centre Approves Pool Testing, Plasma Therapy For Maharashtra

Plasma therapy has indeed raised hopes of the people, but what are the dos and don’ts? NDTV spoke to a group of medical experts – Dr Ravindra Mehta, Chief of Pulmonary and Critical Care Medicine at Apollo Hospitals in Bengaluru; Anurag Mehrotra, Chief Cardiologist at Siddh Hospital in Moradabad, Uttar Pradesh; Dr Sandeep Budhiraja, Group Medical Director, Max Healthcare; Dr Suresh Kumar, Medical Director at LNJP; Dr Guido Vanham, Virologist; Dr Ravi Godse, Attending Physician, UPMC, Pennsylvania; Dr Pramod Gandhi, Endocrinologist; Dr Vivek Nangia, Director, Pulmonology, Fortis Hospital Vasant Kunj.

How Does Plasma Therapy Work?

Blood plasma, a yellowish liquid is a component of blood and consists of protein, minerals and anitbodies. If someone has recovered from COVID-19 there are chances that the person’s body has developed antibodies that helped him/her to fight the virus. The same antibodies, if infused into a critical patient may provide passive immunity and help in the recovery process.

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

Also Read: Ghaziabad Duo Design App To Match Plasma Donors For COVID Patients

What Is The Procedure Of Convalescent Plasma Therapy?

The procedure of donating plasma and transfusing it into someone’s body is similar to blood transfusion. Plasma from a patient who has recovered from coronavirus infection is taken out and infused Intravenously (IV).

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

Explaining the procedure, Dr Ravindra Mehta, Chief of Pulmonary and Critical Care Medicine at Apollo Hospitals in Bengaluru, says,

First blood is drawn to check the level of antibodies. Once it’s clear that an individual can donate plasma, we take blood, then we separate plasma from the blood and give that to a compatible person, not to everyone. The point to be noted is, only plasma is taken from the blood and at the end, blood is sent back to the body. The plasma can either be immediately given to the prospective patient or stored for a year.

Among many donors is 36-year-old Tabrez Khan who donated his plasma at the Institute of Liver and Biliary Sciences (ILBS) in South Delhi. Talking to NDTV about the process, Mr Khan says,

It was very easy. In total, it took two hours in the hospital, which includes blood testing, reports analysis, the process of extracting blood and then removing the plasma from it and infusing the remaining blood again in the body. The hospital also made all arrangements.

Also Read: Fight Against COVID-19: Tests To Soon Touch 1 Crore; 1,065 Testing Labs Across India, Says Union Health Ministry

Who Can Donate Plasma?

Patients who have passed through the cycle of coronavirus, who have recovered from COVID-19, can donate plasma because only they have developed the immunity against this virus, says Dr Anurag Mehrotra, Chief Cardiologist at Siddh Hospital in Moradabad, Uttar Pradesh.

This means that a healthy individual or anyone who has not had COVID-19 cannot donate plasma. According to Dr Ravindra Mehta, Plasma can be donated after 14 days of recovering from the disease.

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

Dr Sandeep Budhiraja, Group Medical Director, Max Healthcare who did the first plasma therapy in India for a COVID patient back in April informs that 500ml of plasma is taken from an individual which can be used for two patients. Also, not all COVID-19 recovered patients can donate plasma. Dr Budhiraja adds,

There are certain restrictions like people less than 18 years of age, individuals over 60 years and people who have contracted any other infection in the recent past cannot donate plasma.

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

Also Read: How Andhra Pradesh Has Been Fighting Against Coronavirus And Is The State Prepared For The Upcoming Peak

Will Donating Plasma Make Me Weak And Prone To COVID-19?

No, donating plasma won’t make the donor weak as only plasma from the blood is taken out and not the blood. Also, there is no evidence to suggest that donating plasma can make one prone to contracting the Novel Coronavirus again.

Fatima Hashmi, a plasma donor and a nurse at Max Super Speciality Hospital, Patparganj encourages people to donate plasma and says,

I’m a nurse and I know how pathetic the Coronavirus condition is right now. Having seen the situation, I decided to donate plasma because what’s better than saving someone’s life? Donating plasma is like donating blood; in fact, easier, as only plasma is extracted. I didn’t feel any weakness or wasn’t exposed to any other virus. Now, I’m back to work also.

23-year-old Smruti Thakkar who is said to be the first recovered patient in Ahmedabad has donated her plasma. Sharing her experience with NDTV, Smruti says,

The doctors who guided me on plasma therapy sounded very positive and confident and gave me the courage to go ahead and donate my plasma. It is 100 per cent safe procedure and not at all painful. It took me 99 minutes. There was no blood loss. During the procedure, I didn’t feel any drowsiness; I was given juices and vitamins.

Also Read: Delhi’s Commonwealth Games Indoor Stadium Converted Into 600 Bedded COVID Care Centre

At What Stage Of COVID-19 Is Plasma Therapy Recommended?

Dr Sandeep Budhiraja reiterates that plasma therapy is not a defined treatment to COVID-19; it’s still being used in some hospitals as an experiment and on compassionate grounds. However, this doesn’t mean that anyone can opt for the said treatment. Explaining the same, Dr Budhiraja says,

There is no point in administering plasma to mild cases of COVID-19 or at an early stage of infection. The convalescent plasma therapy is not much effective when a patient is on a ventilator. The best stage to give plasma is ‘moderate severity’ – when the patient’s requirement of oxygen increases.

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

Dr Suresh Kumar, Medical Director at LNJP (Lok Nayak) Hospital in Delhi says that plasma therapy benefits people more who are under 65 years of age; have only SARI (severe acute respiratory infections); acute respiratory failure because of COVID; oxygen saturation is less than 90.

If we give plasma before cytokine storm, before multi-organ failure stage then the chances of survival are high, says Dr Kumar.

Also Read: Coronavirus Outbreak Explained: What Is A Cytokine Storm And How Is It Fuelling COVID-19? Experts Answer

Is Plasma Therapy The Only Way To Treat COVID-19?

In the absence of a vaccine against COVID-19, plasma therapy is being looked upon as a potential treatment. But this has not been approved by ICMR yet; it’s being tried as an experimental therapy. Though the treatment has given positive results, Dr Randeep Guleria, Director, All India Institute of Medical Sciences (AIIMS) has asked to not look at the treatment as ‘magic bullets’. Speaking to the news agency ANI, he said,

Plasma therapy is not the only treatment strategy and it is not that it will be effective in all patients because there are a number of other things happening in people affected with coronavirus. Also, patients willing to give blood after 14 days of recovery must contain a good amount of antibodies.

Also Read: Coronavirus Outbreak Explained: What Is Antibody Test And What Role Does It Play In The Fight Against COVID-19?

Dr Guleria adds,

We need to look at it with a research type of treatment modality rather than something which can be done for all patients suffering from COVID-19.

Is There Any Evidence To Support The Use Of Plasma Therapy?

Plasma therapy is not a new concept; in fact, in the past, it has proven to be helpful in the treatment of other diseases like Hepatitis B. Sharing his opinion on plasma therapy and how successful it can be, Dr Guido Vanham, Virologist said,

Plasma therapy has been successfully used in Hepatitis B and unsuccessful in case of HIV and Hepatitis C. There is data from China that about 30 per cent of people who have recovered do not develop neutralising anti-bodies that can block the virus. If that is the case then the therapy will not be universally successful, but you can expect 60-70 per cent success.

Also Read: Coronavirus Outbreak Explained: What Is A Pulse Oximeter And Why Is It Becoming A Tool Against COVID-19?

Hoping that plasma therapy is going to be affective, Dr Ravi Godse, Attending Physician, UPMC, Pennsylvania, said,

In US, FDA has approved it and trials have just started. We hope that plasma is going to be effective. Whether we know it is going to be effective or not, the time to start collecting plasma is right now. We are hoping that the peak doesn’t come to India but in case it comes to India, we should start collecting the plasma and be ready.

Why Is ICMR Not Approving Plasma Therapy As A Treatment For COVID-19?

Anup Agarwal, Consultant at ICMR said that currently, we do not know how effective convalescent Plasma is and added,

This is the reason ICMR is doing a randomised clinical study. We do not know whether or not it will be effective in critically ill patients of COVID -19. It will take 3-6 months to put out the findings of the research.

Also Read: Coronavirus Myth Busted: Do Poultry Products Such As Eggs, Meat Cause COVID-19?

Coronavirus Outbreak Explained: What Is Convalescent Plasma Therapy And How Effective Is It In Treating COVID-19 Patients?

ICMR Director General Dr Balram Bhargava said in an opinion piece written for The Hindu newspaper,

Scientific research in medicine is the only means to overcome novel and complex diseases such as COVID-19 and that too thrives on the same spirit of debate and criticism. So is the case with the convalescent plasma therapy that is being currently studied by the Indian Council of Medical Research, through open label, randomised controlled trial to evaluate it for both safety and efficacy. In theory, the antibodies of the recovered person may help that patient’s immune system fight the virus. While showing great promise, it is a line of treatment that is yet to be validated for efficacy and safety and cannot be deployed widely without caution. The current evidence to conclude anything about the true benefits of this therapy is very thin.

Dr Bhargava also noted that plasma therapy involves risks that make it even more important to study it thoroughly before suggesting it as a treatment.

Are There Any Risks Involved In Plasma Therapy?

Blood transfusion related infections can be transmitted so before plasma transfusion, we need to do other tests like HIV. These are routine tests and are done for all transfusions, says Dr Pramod Gandhi, Endocrinologist.

Further talking about the risks involved and ICMR’s take, Dr Vivek Nangia, Director, Pulmonology, Fortis Hospital Vasant Kunj says,

Plasma therapy has been tried during different pandemics and gave only modest results. In the case of Ebola and MERS, the therapy failed completely. To conduct this therapy, it’s important to know if there are enough antibodies available in the body of COVID-19 recovered patients. But the antibodies test we have is qualitative and not quantitative.

Also Read: Coronavirus Outbreak Explained: What Is A Coronavirus And COVID-19?

Dr Kumar from LNJP says plasma therapy should not be given to patients with a liver problem, renal failure, alcoholics and cancer patients.

Conclusion

As of now, in the treatment of COVID-19 patients, plasma therapy has shown positive results. ICMR categorises CPT as ‘experimental’. Doctors can ask patients to take part in CPT trial and patients can be added to it only with the approval of hospital ethics committees. However, lately, the reports have shown that COVID-19 patients are struggling to find plasma. For instance, it took Shweta Singh, a resident of Delhi, three days to arrange plasma for 58-year-old father. Now, with the government’s involvement in the CPT trial, the search will become easier.

Also Read: 6 Months On, What Do We Know About The Coronavirus Pandemic

World

4,44,51,707Cases
1,32,31,846Active
3,00,46,052Recovered
11,73,809Deaths
Coronavirus has spread to 189 countries. The total confirmed cases worldwide are 4,44,51,707 and 11,73,809 have died; 1,32,31,846 are active cases and 3,00,46,052 have recovered as on October 29, 2020 at 3:43 am.

India

80,40,203 49881Cases
6,03,687 -7116Active
73,15,989 56480Recovered
1,20,527 517Deaths
In India, there are 80,40,203 confirmed cases including 1,20,527 deaths. The number of active cases is 6,03,687 and 73,15,989 have recovered as on October 29, 2020 at 2:30 am.

State & District Details

State Cases Active Recovered Deaths
DistrictCases
Mumbai45,478
Thane13,660
Pune9,920
Mumbai Suburban5,363
Aurangabad1,974
Nashik1,575
Raigad1,462
Palghar1,421
Solapur1,291
Jalgaon1,039
Akola757
Nagpur692
Kolhapur646
Satara629
Ratnagiri350
Amravati291
Dhule228
Hingoli208
Jalna201
Ahmednagar190
Nanded176
Yavatmal150
Sangli145
Latur139
Osmanabad125
Sindhudurg114
Buldhana88
Parbhani78
gondia69
Beed54
Nandurbar42
Gadchiroli42
Bhandara41
Chandrapur32
Washim13
Wardha11

16,60,766 6,738

1,30,286 1,783

14,86,926 8,430

43,554 91

DistrictCases
Kurnool795
Krishna557
Guntur511
Anantapur428
East Godavari356
Chittoor319
Sri Potti Sriramulu Nell*296
Y.S.R.205
West Godavari199
Srikakulam183
Prakasam104
Visakhapatnam103
Vizianagaram23

8,14,774 2,949

26,622 678

7,81,509 3,609

6,643 18

DistrictCases
Udupi1,176
Kalaburagi669
Yadgir538
Bengaluru Urban529
Raichur369
Mandya346
Belagavi337
Bidar219
Hassan205
Davangere204
Vijayapura201
Dakshina Kannada179
Chikkaballapura149
Mysuru107
Bagalkote103
Uttara Kannada95
Shivamogga67
Dharwad61
Ballari60
Gadag45
Bengaluru Rural40
Tumakuru36
Kolar29
Haveri24
Chikkamagaluru19
Chitradurga14
Koppal5
Kodagu4
Ramanagara3
Chamarajanagara0

8,12,784 3,146

68,180 3,169

7,33,558 6,260

11,046 55

DistrictCases
Chennai23,324
Chengalpattu1,314
Thiruvallur774
Villupuram509
Kanchipuram503
Tiruvannamalai496
Cuddalore477
Ariyalur444
Tirunelveli433
Tuticorin333
Kallakurichi324
Madurai322
Salem258
Coimbatore188
Virudhunagar185
Dindigul175
Perambalur133
Ranipet133
Thanjavur130
Theni129
Tiruchirappalli119
Ramanathapuram119
Tiruppur116
Kanniyakumari110
Tenkasi103
Nagapattinam99
Karur88
Namakkal83
Erode75
Vellore71
Thiruvarur67
Pudukkottai53
Sivaganga46
Tirupathur45
Krishnagiri43
The Nilgiris17
Dharmapuri15

7,16,751 2,516

26,356 1,378

6,79,377 3,859

11,018 35

DistrictCases
Gautam Buddha Nagar1,119
Agra933
Ghaziabad794
Meerut504
Lucknow386
Saharanpur298
Kanpur Nagar286
Moradabad252
Varanasi243
Hapur225
Aligarh215
Basti214
Amethi206
Rampur203
Jaunpur194
Firozabad190
Barabanki168
Gorakhpur166
Bulandshahr166
Siddharth Nagar159
Ghazipur159
Bijnor157
Deoria143
Azamgarh138
Sant Kabeer Nagar132
Mathura129
Ayodhya120
Muzaffarnagar117
Sambhal116
Sultanpur97
Ambedkar Nagar92
Maharajganj85
Amroha80
Rae Bareli78
Bahraich73
Kheri72
Kannauj69
Baghpat68
Kushi Nagar67
Bhadohi60
Ballia60
Gonda59
Etah52
Hardoi49
Balrampur49
Mau48
Mainpuri46
Etawah46
Hathras43
Unnao42
Jalaun41
Jhansi41
Shamli40
Chandauli38
Auraiya37
Farrukhabad36
Sitapur32
Prayagraj30
Banda27
Shahjahanpur25
Shravasti23
Budaun23
Mirzapur22
Bareilly17
Kasganj16
Pratapgarh15
Pilibhit15
Sonbhadra10
Kaushambi6
Kanpur Dehat4
Chitrakoot4
Lalitpur3
Hamirpur3
Mahoba3
Fatehpur3

4,76,034 1,980

25,487 780

4,43,589 2,742

6,958 18

DistrictCases
Kannur357
Kasaragod333
Palakkad224
Malappuram119
Kollam118
Thrissur106
Thiruvananthapuram104
Pathanamthitta98
Kozhikode90
Alappuzha76
Kottayam73
Ernakulam60
Idukki40
Wayanad36

4,11,464 8,790

93,369 1,103

3,16,692 7,660

1,403 27

DistrictCases
North West5,463
Central4,817
West4,768
New Delhi3,405
North3,059
East2,472
South East2,446
South West2,391
South2,329
North East1,914
Shahdara1,580

3,70,014 5,673

29,378 1,505

3,34,240 4,128

6,396 40

DistrictCases
Kolkata2,777
Howrah1,435
24 Paraganas North1,031
Hooghly604
24 Paraganas South281
Maldah235
Dinajpur Uttar216
Coochbehar210
Birbhum206
Medinipur West159
Medinipur East153
Nadia139
Purba Bardhaman130
Murshidabad125
Bankura116
Darjeeling97
Jalpaiguri88
Paschim Bardhaman70
Purulia66
Dinajpur Dakshin50
Alipurduar39
Kalimpong18
Jhargram9

3,61,703 3,924

37,111 61

3,17,928 3,925

6,664 60

DistrictCases
Ganjam581
Jajapur322
Khordha238
Baleshwar190
Kendrapara164
Cuttack155
Bhadrak137
Balangir129
Puri103
Sundargarh102
Jagatsinghapur91
Nayagarh86
Mayurbhanj73
Nuapada69
Gajapati61
Dhenkanal36
Boudh34
Kendujhar34
Deogarh33
Kalahandi33
Sonepur29
Kandhamal28
Anugul26
Malkangiri20
Bargarh16
Koraput16
Sambalpur16
Jharsuguda8
Nabarangpur2
Rayagada2

2,85,482 1,540

14,068 487

2,70,130 2,015

1,284 12

DistrictCases
Hyderabad2,475
Ranga Reddy183
Suryapet87
Jagitial77
Nizamabad76
MedchalMalkajgiri75
Mancherial43
YadadriBhuvanagiri40
Jogulamba Gadwal40
Vikarabad40
Nalgonda33
Warangal Urban32
Mahabubnagar30
Sangareddy26
Khammam26
Adilabad22
Nirmal21
Karimnagar17
RajannaSircilla16
Medak11
Kamareddy11
Mahabubabad10
Jayashankar Bhupalapally9
Nagarkurnool8
Kumuram Bheem Asifabad8
Jangoan8
Siddipet7
Peddapalli5
Bhadradri Kothagudem5
Warangal Rural4
Mulugu3
Narayanpet3
Wanaparthy1

2,35,656 1,504

17,979 63

2,16,353 1,436

1,324 5

DistrictCases
Patna279
Bhagalpur266
Rohtas256
Khagaria253
Begusarai243
Madhubani199
Munger188
Jehanabad178
Katihar175
Darbhanga143
Samastipur139
Siwan139
PurbiChamparan138
Purnia135
Banka134
Buxar134
Nalanda123
Gopalganj123
Nawada122
Sheikhpura118
Gaya115
Kaimur (bhabua)105
Bhojpur103
Saran101
Muzaffarpur96
Saharsa88
Supaul87
Vaishali87
Madhepura82
Kishanganj75
Aurangabad75
Sitamarhi73
Lakhisarai72
Araria68
Pashchim Champaran57
Arwal52
Jamui47
Sheohar20

2,13,576 491

8,329 517

2,04,178 1,004

1,069 4

DistrictCases
Kamrup Metro276
Golaghat203
Nagaon143
Hojai89
Dima Hasao86
Karimganj85
Tinsukia84
Cachar80
Dibrugarh61
Hailakandi57
Lakhimpur57
Marigaon50
Dhemaji47
Kamrup42
Kokrajhar37
Dhubri30
Charaideo29
Barpeta28
Udalguri28
Sonitpur27
Jorhat24
Nalbari23
Darrang20
Sivasagar20
Goalpara19
Biswanath16
Baksa14
KarbiAnglong13
Bongaigaon12
Chirang6
West KarbiAnglong5
South SalmaraMancachar4
Majuli2

2,05,237 448

11,803 1,042

1,92,517 1,487

917 3

DistrictCases
Jaipur2,177
Jodhpur1,748
Udaipur724
Bharatpur563
Kota503
Nagaur500
Ajmer379
Dungarpur374
Pali352
Jhalawar329
Bhilwara250
Sikar231
Chittorgarh188
Tonk171
Jalore164
Rajsamand140
Sirohi130
Bikaner112
Banswara91
Alwar90
Churu81
Jhunjhunu64
Dausa61
Dholpur60
Baran59
Jaisalmer53
Barmer34
Hanumangarh31
SawaiMadhopur26
Karauli17
Pratapgarh14
Ganganagar8
Bundi5

1,91,629 1,785

15,708 241

1,74,044 2,016

1,877 10

DistrictCases
Bilaspur100
Korba100
Mungeli87
Baloda Bazar85
Jashpur77
Janjgir-Champa56
Mahasamund54
Rajnandgaon52
Kabirdham52
Raigarh47
Raipur46
Balod41
Korea39
Durg31
Bemetara21
Kanker19
Balrampur17
Surguja14
Gariyaband10
Surajpur9
Dhamtari6
Bijapur2
Bastar2
Dantewada0
Kondagaon0
Narayanpur0
Sukma0

1,81,583 1,929

22,167 474

1,57,480 1,400

1,936 55

DistrictCases
Ahmadabad17,125
Surat2,311
Vadodara1,555
Gandhinagar410
Mahesana159
Banas Kantha147
Bhavnagar146
Rajkot135
Arvalli134
Mahisagar125
Anand107
PanchMahals107
Patan105
SabarKantha101
Kachchh99
Kheda98
Jamnagar63
Bharuch56
Botad55
Surendranagar55
Valsad47
GirSomnath45
Dohad43
Chhotaudepur37
Naysari35
Junagadh31
Narmada25
DevbhumiDwarka22
Amreli16
Porbandar11
Tapi6
Dang5
Morbi4

1,69,891 980

13,332 133

1,52,858 1,107

3,701 6

DistrictCases
Indore3,839
Bhopal1,880
Ujjain799
Burhanpur351
Neemuch319
Jabalpur276
East Nimar266
Sagar228
Gwalior211
Khargone196
Dewas140
Dhar132
Mandsaur112
Morena109
Bhind87
Raisen71
Barwani60
Ratlam51
Rewa39
Shajapur39
Hoshangabad37
Vidisha37
Chhatarpur35
Betul35
Rajgarh31
Dindori29
Sheopur26
Damoh26
Satna24
Anuppur22
Panna20
Tikamgarh18
Sidhi17
Narsinghpur17
Chhindwara16
Agar Malwa15
Mandla15
Shivpuri15
Jhabua14
Shandol14
Singrauli13
Ashoknagar13
Datia12
Sehore12
Umaria10
Balaghat9
Guna8
Harda4
Alirajpur3
Katni3
Seoni2
Niwari0

1,69,271 788

10,094 259

1,56,264 1,032

2,913 15

DistrictCases
Gurugram2,950
Faridabad867
Sonipat404
Rohtak145
Palwal120
Jhajjar114
Karnal104
Hisar98
Ambala93
Panipat78
Nuh68
Bhiwani60
Rewari56
Kurukshetra55
Sirsa50
Kaithal48
Mahendragarh47
CharkiDadri43
Panchkula39
Fatehabad38
Jind38
Yamunanagar19

1,62,223 1,518

11,014 562

1,49,451 948

1,758 8

DistrictCases
Amritsar485
Jalandhar297
Ludhiana293
Tarn Taran163
Gurdaspur154
Hoshiarpur140
S.A.S Nagar137
Patiala132
Sangrur107
Shahid Bhagat Singh Nagar (Nawanshahr)99
Pathankot86
Rupnagar (Ropar)74
Faridkot74
Sri Muktsar Sahib71
Moga65
Bathinda60
Fatehgarh Sahib57
Fazilka53
Firozepur50
Kapurthala44
Mansa31
Barnala25

1,32,263 526

4,239 150

1,23,866 356

4,158 20

DistrictCases
East Singhbum170
Ranchi148
Hazaribagh110
Garhwa80
Ramgarh75
Koderma58
Simdega48
Dhanbad32
Gumla28
Palamu27
West Singhbhum21
SaraikelaKharsawan20
Giridih19
Bokaro16
Latehar14
Khunti10
Lohardaga8
Deoghar5
Dumka5
Pakur4
Jamtara2
Godda2
Chatra1
Sahebganj0

1,00,569 345

5,363 111

94,326 452

880 4

DistrictCases
Anantnag395
Srinagar300
Kulgam295
Baramulla271
Shopian255
Kupwara231
Bandipora175
Udhampur155
Ramban151
Jammu138
Budgam110
Pulwama108
Kathua53
Rajouri39
Ganderbal37
Poonch35
Doda27
Reasi26
Samba25
Kishtwar10
Mirpur0
Muzaffarabad0

93,213 536

6,976 14

84,782 546

1,455 4

DistrictCases
Dehradun370
Nainital323
Tehri Garhwal110
Haridwar94
Udam Singh Nagar83
Almora71
Champawat45
Pithoragarh43
Chamoli36
PauriGarhwal36
Bageshwar31
Rudraprayag30
Uttar Kashi24

61,261 304

3,696 169

56,556 471

1,009 2

DistrictCases
South Goa69
North Goa57

42,968 221

2,402 18

39,974 196

592 7

DistrictCases
Pondicherry111
Mahe4
Karaikal2
Yanam0

34,583 101

3,686 55

30,307 154

590 2

DistrictCases
Dhalai196
Sepahijala174
Gomati74
South Tripura53
Unakoti49
West Tripura45
Khowai24
North Tripura14

30,566 113

1,696 58

28,525 170

345 1

DistrictCases
Hamirpur117
Kangra105
Una41
Solan32
Chamba29
Bilaspur21
Mandi21
Sirmaur11
Shimla10
Kullu4
Kinnaur2
Lahaul And Spiti0

21,149 332

2,646 125

18,203 205

300 2

DistrictCases
Churachandpur32
Kangpokpi26
Imphal West21
Thoubal18
Imphal East10
Tengnoupal9
Bishnupur7
Senapati6
Chandel5
Kamjong5
Ukhrul4
Jiribam3
Pherzawl3
Kakching2
Tamenglong2
Noney1

17,809 205

4,233 13

13,420 212

156 6

DistrictCases
Changlang31
Papum Pare8
Lohit3
Namsai2
West Siang1
East Siang1
Upper Siang1
Tawang1
PakkeKessang1
West Kameng0
Upper Subansiri0
Tirap0
Siang0
Shi Yomi0
Anjaw0
Lower Subansiri0
Lower Dibang Valley0
Longding0
Leparada0
KurungKumey0
KraDaadi0
Kamle0
East Kameng0
Dibang Valley0
Lower Siang0

14,580 108

2,064 75

12,480 183

36

DistrictCases
Chandigarh313

14,212 60

629 21

13,359 80

224 1

DistrictCases
East Khasi Hills22
West Garo Hills5
South West Garo Hills4
North Garo Hills1
West Jaintia Hills1
West Khasi Hills1
East Garo Hills0
East Jaintia Hills0
Ribhoi0
South Garo Hills0
South West Khasi Hills0

9,226 90

1,364 47

7,777 134

85 3

DistrictCases
Dimapur20
Mon8
Kohima7
Kiphire3
Tuensang3
Peren2
Phek1
Longleng0
Mokokchung0
Wokha0
Zunheboto0

8,824 98

1,845 20

6,945 117

34 1

DistrictCases
Kargil77
LehLadakh43

6,085 61

642 47

5,369 107

74 1

DistrictCases
South Andamans33
Nicobars1
North And Middle Andaman1

4,289 15

192 5

4,039 20

58

DistrictCases
East District3
South District3
North District0
West District0

3,875 12

263 1

3,545 11

67

DistrictCases
Dadra And Nagar Haveli20

3,237 6

51 3

3,184 3

2

DistrictCases
Kolasib11
Aizawl10
Mamit8
Lawngtlai2
Lunglei2
Saitual1
Champhai0
Hnahthial0
Khawzawl0
Saiha0
Serchhip0

2,656 49

417 43

2,238 5

1 1

DistrictCases
Lakshadweep District0

0

0 0

0

0

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