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COVID-19 Variant N440K Spreading More In Southern States: Centre For Cellular And Molecular Biology

Scientists from Centre for Cellular and Molecular Biology, in a recent publication, have presented an exhaustive analysis of over 5,000 coronavirus variants in India and how they have evolved over the course of the pandemic

COVID-19 Variant N440K Spreading More In Southern States: Centre For Cellular And Molecular Biology
Highlights
  • Closer surveillance is needed to understand spread of new strains: CCMB
  • Different coronavirus variants have gained prevalence in India: CCMB
  • Due to natural process of mutation, variants will keep emerging: Experts

Hyderabad: The Hyderabad-based Centre for Cellular and Molecular Biology (CSIR-CCMB) said there is emerging evidence that coronavirus variant N440K is spreading “a lot more” in southern states in the country. Scientists from CSIR-CCMB, in a recent publication, have presented an exhaustive analysis of over 5,000 coronavirus variants in India and how they have evolved over the course of the pandemic.

Also Read: Amravati Surge Due To Mutation, People’s Carelessness: Maharashtra Official

Dr Rakesh Mishra, Director, CCMB and corresponding author on the study said,

The novel variants that are worrying many countries globally have been identified with only a low prevalence in India so far. These include the variants with immune-escape E484K mutation and the N501Y mutation with higher transmission rate. However, their apparent low prevalence might be simply because not enough sequencing has been done. More coronavirus genomes need to be sequenced across the country to accurately identify the emergence of these and other new variants.

According to a release by CSIR-CCMB, the study also finds that a few novel variants are spreading more in some states of India.

We now have emerging evidence that N440K is spreading a lot more in southern states. Closer surveillance is needed to understand its spread properly. Accurate and timely detection of new variants that may show greater infectivity or worse clinical symptoms, including immune escape, will be extremely important to preempt disastrous consequences, said Dr Mishra.

In the paper, the authors explain how different coronavirus variants gained prevalence in India during the last year.

One of the variants called the A3i had mutations that were predicted to make its spread slower. The study confirms that it was overtaken by the globally prevalent A2a variant, carrying the D614G mutation, by June 2020. The A2a variant has remained in global dominance for the major part of the year 2020. The recently discovered variants in many countries have raised concerns because of their mutations in the Spike protein, that makes the coat of the virus and come in contact with the human cells. The Spike protein is required for binding to the receptors on human cells. Mutations in this protein can help the virus in some cases. It can increase viral transmission rates by enhancing its affinity to human receptors. Some of these coronavirus variants can also be immune-escape and cause reinfection. Our immune systems cannot identify them from previous infections because of the changes in their protein structures, read the release.

Also Read: COVID-19 Vaccines Myth Vs Fact: No Vaccines Do Not Alter DNA

The paper documents the Spike mutation landscape of SARS-CoV-2, showcasing the ones that have emerged with high prevalence in the country and abroad.

Spike protein mutations have implications in COVID-19 surveillance and management, vaccines, therapeutics, and the emergence of re-infections. We need to have a focused approach towards monitoring the virus mutations. India has not been sequencing SARS-CoV-2 isolates to full capacity, having deposited only about 6,400 genomes so far. The Indian government’s initiative of INSACOG, which aims to sequence 5 per cent of all positive cases, should soon address this, said Dr Divya Tej Sowpati, the co-corresponding author.

Dr Surabhi Srivastava, the lead author of the study said the success in the development and administration of vaccines is promising but other non-therapeutic prevention measures, such as masks and physical distancing, will still prove to be the most effective in curbing further spread of the disease. Lesser spread of the virus also decreases the scope for emergence and accumulation of harmful mutants, she said.

The take-home of this comprehensive work is that due to the natural process of mutation, variants will keep emerging. The best way to control the potential damage is to exercise extensive genome surveillance and take measures to prevent the spread of new variants as and when detected, read the release.

Also Read: WHO’s Team Tracing the Origin Of COVID-19 Is Back From China; Experts Explain Why It Is Important To Find The Source Of The Outbreak

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

24,06,78,961Cases
20,23,40,977Active
3,34,39,331Recovered
48,98,653Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 24,06,78,961 and 48,98,653 have died; 20,23,40,977 are active cases and 3,34,39,331 have recovered as on October 18, 2021 at 4:17 am.

India

3,40,81,315 13,596Cases
1,89,6946,152Active
3,34,39,331 19,582Recovered
4,52,290 166Deaths
In India, there are 3,40,81,315 confirmed cases including 4,52,290 deaths. The number of active cases is 1,89,694 and 3,34,39,331 have recovered as on October 18, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,91,697 1,715

32,230 994

64,19,678 2,680

1,39,789 29

Kerala

48,54,321 7,555

88,186 3,292

47,39,270 10,773

26,865 74

Karnataka

29,83,459 326

9,479 58

29,36,039 380

37,941 4

Tamil Nadu

26,87,092 1,218

14,814 208

26,36,379 1,411

35,899 15

Andhra Pradesh

20,60,472 432

6,034 159

20,40,131 586

14,307 5

Uttar Pradesh

17,10,028 9

119 10

16,87,011 19

22,898

West Bengal

15,80,530 624

7,421 24

15,54,132 634

18,977 14

Delhi

14,39,390 32

320 6

14,13,981 38

25,089

Odisha

10,35,077 443

4,542 68

10,22,250 508

8,285 3

Chhattisgarh

10,05,654 16

183 2

9,91,901 14

13,570

Rajasthan

9,54,390 2

42 2

9,45,394 4

8,954

Gujarat

8,26,290 10

207 6

8,15,997 16

10,086

Madhya Pradesh

7,92,684 5

84 12

7,82,077 17

10,523

Haryana

7,71,076 15

123 9

7,60,904 6

10,049

Bihar

7,26,026 5

48 4

7,16,317 1

9,661

Telangana

6,68,955 122

3,924 55

6,61,093 176

3,938 1

Assam

6,06,468 205

3,436 46

5,97,082 245

5,950 6

Punjab

6,02,035 27

227 8

5,85,264 16

16,544 3

Jharkhand

3,48,430 7

122 1

3,43,173 8

5,135

Uttarakhand

3,43,756 9

178 1

3,36,181 8

7,397

Jammu And Kashmir

3,31,062 95

843 12

3,25,793 107

4,426

Himachal Pradesh

2,21,437 131

1,303 5

2,16,414 125

3,720 1

Goa

1,77,522 60

604 6

1,73,572 62

3,346 4

Puducherry

1,27,396 52

585 13

1,24,961 64

1,850 1

Manipur

1,22,737 104

1,422 0

1,19,418 102

1,897 2

Mizoram

1,12,848 249

11,633 1,143

1,00,829 1,389

386 3

Tripura

84,321 16

104 4

83,401 12

816

Meghalaya

82,953 55

845 32

80,673 86

1,435 1

Chandigarh

65,302 3

25 3

64,457 6

820

Arunachal Pradesh

54,987 7

140 30

54,567 37

280

Sikkim

31,749 4

174 8

31,184 12

391

Nagaland

31,611 40

248 12

30,689 28

674

Ladakh

20,878 2

36 10

20,634 12

208

Dadra And Nagar Haveli

10,676 1

4 1

10,668

4

Lakshadweep

10,365

0 0

10,314

51

Andaman And Nicobar Islands

7,641

9 0

7,503

129

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