Pfizer Far Less Effective For Delta Variant Than Earlier Coronavirus Strains: Lancet Study

Pfizer Far Less Effective For Delta Variant Than Earlier Coronavirus Strains: Lancet Study

The study also shows that levels of these antibodies that are able to recognise and fight the virus are lower with increasing age, and that levels decline over time, providing additional evidence in support of plans to deliver a booster dose to vulnerable people
Coronavirus Outbreak, Coronavirus Vaccine, News
- in Coronavirus Outbreak, Coronavirus Vaccine, News
0
Pfizer Far Less Effective For Delta Variant Than Earlier Coronavirus Strains: Lancet StudyThe study analysed antibodies in the blood of 250 healthy people who received the Pfizer vaccine
Highlights
  • Delta variant was first identified in India
  • Study tested ability of antibodies to block entry of the virus into cells
  • This virus will likely be around for some time to come: Expert

London: People fully vaccinated with the Pfizer-BioNTech vaccine are likely to have more than five times lower levels of neutralising antibodies against the Delta variant first identified in India compared to the original strain, according to research published in The Lancet journal. The study also shows that levels of these antibodies that are able to recognise and fight the virus are lower with increasing age, and that levels decline over time, providing additional evidence in support of plans to deliver a booster dose to vulnerable people.

Also Read: Coronavirus Explained: All You Need To Know About The COVID-19 Vaccine For Children In India

It supports current plans in the UK to reduce the dose gap between vaccines since they found that after just one dose of the Pfizer-BioNTech vaccine, people are less likely to develop antibody levels against the B.1.617.2 variant as high as those seen against the previously dominant B.1.1.7 (Alpha) variant, first found in Kent.

The team, led by researchers from the Francis Crick Institute in the UK, noted that levels of antibodies alone do not predict vaccine effectiveness and prospective population studies are also needed. Lower neutralising antibody levels may still be associated with protection against COVID-19, they said.

The study analysed antibodies in the blood of 250 healthy people who received either one or two doses of the Pfizer-BioNTech Covid-19 vaccine, up to three months after their first dose.

The researchers tested the ability of antibodies to block entry of the virus into cells, so called ‘neutralising antibodies’, against five different variants of SARS-CoV-2.

They then compared concentrations of these neutralising antibodies between all variants.

Data from previous clinical studies suggests that higher antibody titres or concentration is a good predictor of vaccine efficacy and greater protection against COVID-19.

The researchers found that in people who had been vaccinated with two doses of the Pfizer-BioNTech vaccine, levels of neutralising antibodies were more than five times lower against the B.1.617.2 variant when compared to the original strain, upon which current vaccines are based.

Also Read: COVID-19 Vaccine Explainer: How Do Vaccines Work?

This antibody response was even lower in people who had only received one dose, they said.

After a single dose of Pfizer-BioNTech, 79 per cent of people had a quantifiable neutralising antibody response against the original strain, but this fell to 50 per cent for B.1.1.7, 32 per cent for B.1.617.2 and 25 per cent for B.1.351 or Beta variant first discovered in South Africa.

While antibody levels decreased with age against all variants, no correlation was observed for sex or body mass index (BMI).

This virus will likely be around for some time to come, so we need to remain agile and vigilant, said Emma Wall, an Infectious Diseases consultant at University College London Hospitals NHS Foundation Trust (UCLH).

Our study is designed to be responsive to shifts in the pandemic so that we can quickly provide evidence on changing risk and protection, Ms Wall said.

The researchers noted that the most important thing is to ensure that vaccine protection remains high enough to keep as many people out of hospital as possible.The study suggests that the best way to do this is to quickly deliver second doses and provide boosters to those whose immunity may not be high enough against these new variants, they said.

Also Read: COVID-19: UK Regulator Approves Pfizer/Biontech Vaccine For 12-15-Year-Olds

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

17,91,56,496Cases
5,81,68,051Active
11,71,06,212Recovered
38,82,233Deaths
Coronavirus has spread to 193 countries. The total confirmed cases worldwide are 17,91,56,496 and 38,82,233 have died; 5,81,68,051 are active cases and 11,71,06,212 have recovered as on June 23, 2021 at 3:45 am.

India

3,00,28,709 50,848Cases
6,43,19419,327Active
2,89,94,855 68,817Recovered
3,90,660 1,358Deaths
In India, there are 3,00,28,709 confirmed cases including 3,90,660 deaths. The number of active cases is 6,43,194 and 2,89,94,855 have recovered as on June 23, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

59,87,521 8,470

1,26,468 1,055

57,42,258 9,043

1,18,795 482

Kerala

28,29,460 12,617

1,00,881 746

27,16,284 11,730

12,295 141

Karnataka

28,15,029 3,709

1,18,615 4,541

26,62,250 8,111

34,164 139

Tamil Nadu

24,36,819 6,895

56,886 4,443

23,48,353 11,144

31,580 194

Andhra Pradesh

18,57,352 4,169

53,880 4,260

17,91,056 8,376

12,416 53

Uttar Pradesh

17,04,678 202

3,910 253

16,78,486 397

22,282 58

West Bengal

14,85,438 1,852

22,508 232

14,45,493 2,037

17,437 47

Delhi

14,32,778 397

1,918 78

14,05,927 467

24,933 8

Chhattisgarh

9,91,653 482

8,007 557

9,70,244 1,032

13,402 7

Rajasthan

9,51,393 137

2,388 303

9,40,101 437

8,904 3

Odisha

8,83,490 2,957

30,859 1,240

8,48,960 4,159

3,671 38

Gujarat

8,22,620 135

5,159 480

8,07,424 612

10,037 3

Madhya Pradesh

7,89,415 65

1,707 273

7,78,902 318

8,806 20

Haryana

7,67,726 146

2,200 137

7,56,231 263

9,295 20

Bihar

7,20,207 268

2,811 206

7,07,833 468

9,563 6

Telangana

6,15,574 1,175

16,640 606

5,95,348 1,771

3,586 10

Punjab

5,93,063 405

5,968 509

5,71,207 880

15,888 34

Assam

4,88,179 2,869

32,975 350

4,50,924 2,482

4,280 37

Jharkhand

3,44,775 110

1,417 72

3,38,256 180

5,102 2

Uttarakhand

3,38,978 171

2,896 68

3,29,030 231

7,052 8

Jammu And Kashmir

3,12,584 428

7,181 578

3,01,134 999

4,269 7

Himachal Pradesh

2,00,791 188

2,276 132

1,95,062 315

3,453 5

Goa

1,64,957 303

2,920 146

1,59,029 438

3,008 11

Puducherry

1,15,364 284

3,214 150

1,10,423 433

1,727 1

Manipur

64,993 575

9,214 84

54,714 649

1,065 10

Tripura

63,140 395

3,747 163

58,735 554

658 4

Chandigarh

61,467 23

278 33

60,383 56

806

Meghalaya

45,976 421

4,273 77

40,915 341

788 3

Arunachal Pradesh

33,664 289

2,548 9

30,956 279

160 1

Nagaland

24,438 64

1,757 87

22,204 149

477 2

Ladakh

19,871 33

360 5

19,309 38

202

Sikkim

19,458 137

2,430 18

16,732 152

296 3

Mizoram

18,409 430

4,424 197

13,900 233

85

Dadra And Nagar Haveli

10,520 4

61 1

10,455 3

4

Lakshadweep

9,504 33

315 4

9,142 36

47 1

Andaman And Nicobar Islands

7,425 10

103 6

7,195 4

127

Coronavirus Outbreak: Full CoverageTesting CentresFAQs

Leave a Reply

Your email address will not be published. Required fields are marked *

You may also like

Is Second Wave Of COVID-19 Over? Positivity Rate Below 5 Per Cent For 15 Days, But Experts Say End Still Far

The second wave of the COVID-19 pandemic overwhelmed the healthcare system of the country, leaving hospitals struggling to cope with the surge in cases and critical drugs and oxygen in short supply