Connect with us

Coronavirus Outbreak

Study Uncovers Subset Of COVID-19 Patients Who Recover Quickly And Sustain Antibodies

The study suggests that some individuals who recover from COVID-19 faster may be mounting a more effective and durable immune response to the virus

Study Uncovers Subset Of COVID-19 Patients Who Recover Quickly And Sustain Antibodies
Highlights
  • For the study, 92 people who had recovered from COVID-19 were enrolled
  • Blood samples were collected and analysed monthly to measure antibodies
  • COVID-19 antibody sustainers had a shorter course of symptoms: Study

Washington: A new study led by investigators from Brigham and Women’s Hospital examined blood samples and cells from patients who had recovered from mild to moderate COVID-19 and found that while antibodies against the virus declined in most individuals after disease resolution, a subset of patients sustained anti-virus antibody production several months following infection. These antibody “sustainers” had a shorter course of symptoms, suggesting that some individuals who recover from COVID-19 faster may be mounting a more effective and durable immune response to the virus. Results are published in Cell.

Also Read: Coronavirus Mutation May Have Made It More Contagious, Finds Study

“We’ve found a subset of individuals that heal quickly while sustaining virus-specific antibody levels after COVID-19,” said Duane Wesemann, MD, PhD, an immunologist and associate physician in the Brigham Division of Allergy and Clinical Immunology and an associate professor at Harvard Medical School.

The kind of immune response we’re seeing in these individuals is a bit like investing in an insurance policy — it’s the immune system’s way of adding a potential layer of protection against future encounters with the virus, added Duane Wesemann.

Also Read: Festivals, Laxity In Adhering To Protocol Behind Surge In COVID-19 Cases In Delhi, Says Government

The Wesemann lab studies the entire set of antibodies a host’s immune system produces and how they learn to recognise pathogens. In the spring of 2020, the team turned its attention to the COVID-19 pandemic and the immune response of people who become infected. They are eager to understand the nature of the antibody response to the virus.

To this end, the team recruited and enrolled 92 people in the Boston area who had recovered from COVID-19 between March and June of 2020. Five of the individuals were hospitalised but all others recovered at home. The team collected and analysed blood samples monthly, measuring a range of antibodies, including immunoglobulin-G (IgG), against the virus that causes COVID-19.

They split the cohort into two groups — those that sustain virus-specific IgG levels over several weeks, and those that lose them. The team analyzed these groups and potential connections they had to clinical and other immunological data.

The team found that IgG levels against the virus tended to decline substantially in most individuals over the course of three to four months. However, in about 20 per cent of individuals, antibody production remained stable or enhanced over the same time period.

The team found that these “sustainers” had symptoms for a significantly shorter period of time compared to “decayers” (average of 10 days versus 16 days). Sustainers also had differences in memory T cell populations and B cells, two types of immune cells that can play a key role in immune memory and protection.

Also Read: Some COVID-19 ‘Long Haulers’ Experience Lasting Skin Problems, States A New Analysis

An important limitation of the study, the team noted, was that most of the volunteers were adult white women. The researchers said that future research must aim to enroll a more diverse population to further elucidate whether variations in immune response exist across people of different ages and ethnic and racial backgrounds.

The researchers also point out that further research may help determine whether similar dynamics of the immune response are also seen in people with asymptomatic and severe disease.

The data point to a type of immune response that’s not only adept at handling viral disease by leading to a swift resolution of symptoms, but also better at producing cells that can commit to longer term production of anti-virus IgG antibodies, said Duane Wesemann.

“Figuring out how these individuals are able to support longer-term antibody production is relevant to COVID-19, and will also have important implications for our understanding of the immune system in general,” added Duane Wesemann.

Also Read: Seven Different Forms Of Mild COVID-19 Identified: Researchers

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

Click to comment

Leave a Reply

Your email address will not be published.

Folk Music For A Swasth India

RajasthanDay” src=

Reckitt’s Commitment To A Better Future

Expert Blog

हिंदी में पड़े

Latest Posts