Connect with us

Coronavirus Outbreak

Two Positive Tests At Interval Of 102 Days With One Negative Defined As SARS-CoV-2 Re-Infection: ICMR Study

While COVID-19 re-infection is still rarely reported, nonetheless, immunity should not be assumed and public health measures such as physical distancing, hand-hygiene, and use of masks should be followed after recovery from first event of infection, said ICMR study

Two Positive Tests At Interval Of 102 Days With One -Ve Defined As SARS-CoV-2 Re-Infection: ICMR Study
Highlights
  • SARS-CoV-2 re-infection is still a rare phenomenon but concerning: ICMR
  • ICMR's new study has defined COVID-19 re-infections
  • Re-infections means a person testing positive twice after a gap: ICMR

New Delhi: Two positive tests at an interval of at least 102 days with one interim negative test have been defined as SARS-CoV-2 re-infection by Indian scientists for establishing surveillance systems, according to an ICMR (Indian Council of Medical Research) study. But a confirmation of the re-infection will require a whole genome sequencing, it stated. While SARS-CoV-2 re-infection is still a rare phenomenon, Indian scientists have developed an easy-to-use epidemiological definition of re-infection for establishing surveillance systems.

Also Read: Compromised COVID Appropriate Behaviour Is Single Largest Reason For Cases Upsurge: Dr. Ram Manohar Lohia Hospital’s Director

According to the study ‘SARS-CoV-2 re-infection: development of an epidemiological definition from India’ which has been published by Cambridge in the Epidemiology and Infection journal, an investigation was conducted with the objective to develop an epidemiological case definition of possible SARS CoV-2 re-infection and assess its magnitude in India.

SARS-CoV-2 re-infection is an emerging concern and there is a need to define it, the scientists highlighted. Therefore, working epidemiological case definition for re-infection was developed and its magnitude was explored via archive-based, telephonic survey. The epidemiological case definition for SARS-CoV-2 reinfection was developed from literature review of data on viral kinetics.

Re-infection with SARS CoV-2 was defined as two positive tests at an interval of at least 102 days with one interim negative test. During the archive based, telephonic survey, thirty-eight of the 58 eligible patients could be contacted, with twelve (31.6 per cent) being healthcare workers. Majority of the participants were asymptomatic and had higher Ct value during their first episode.

To conclude, a working epidemiological case definition of SARS CoV-2 re-infection is important to strengthen surveillance. The present investigation contributes to this goal and records reinfection in 4.5 per cent of SARS CoV-2 infected individuals in India, the study stated.

Also Read: Pfizer-BioNTech Say COVID-19 Vaccine Protection Lasts At Least Six Months, Effective Against South African Variant

Taking available evidence into consideration, re-infection with SARS CoV-2 in our study was defined as any individual who tested positive for SARS-CoV-2 on two separate occasions by either molecular tests or rapid antigen test at an interval of at least 102 days with one negative molecular test in between, the study stated.

While SARSCoV-2 re-infection is still a rare phenomenon, there is a need for an epidemiological definition of re-infection for establishing surveillance systems and this study contributes to such goal, it said.

Some respondents in the study had a symptomatic second episode as opposed to the first one. The rate and duration of hospitalisation was not compared as during the initial phase of the pandemic in India all cases were being hospitalized for at least 14 days, irrespective of symptom severity.

Currently, there is no consensus regarding the working definition of re-infection, based only on epidemiological features; a resource intensive method like whole genome sequencing being the only confirmation.

It is not logistically feasible to store the samples of millions of positive cases for future sequencing to identify an important phenomenon like SARS CoV-2 re-infection, the study said.

Also Read: New Portable Test To Diagnose COVID-19 Quickly, Track Variants

Centers for Disease Control and Prevention (CDC) has considered the duration of 90 days between two positive SARS-CoV-2 RNA along with genomic evidence of re-infection as an investigative criterion to understand the phenomenon of reinfection. Both CDC and European CDC suggested the use of genomic evidence for confirmation of reinfection, However, an epidemiological working definition will be more pragmatic and helpful to assess the magnitude of re-infection in most population and resource constrained settings.

While COVID-19 re-infection is still rarely reported, nonetheless, immunity should not be assumed and public health measures such as physical distancing, hand-hygiene, and use of masks should be followed after recovery from first event of infection, the study stated.

Further well-designed cohort studies must be undertaken to understand the natural history of COVID-19, including its immunogenicity, susceptibility to re-infection, antibody dependent enhancement and the severity of re-infections. It may also be suggested that the samples of healthcare workers may be stored for genomic analysis to study suspected COVID-19 reinfections, particularly in resource limited settings as chances of them encountering such events are higher due to potential high-risk occupational exposure.

Also Read: Administer 5-10 Million COVID Vaccine Doses Per Day, Do Genomic Surveillance For Variants: Expert On COVID In India

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

26,06,51,261Cases
22,14,73,133Active
3,39,88,797Recovered
51,89,331Deaths
Coronavirus has spread to 196 countries. The total confirmed cases worldwide are 26,06,51,261 and 51,89,331 have died; 22,14,73,133 are active cases and 3,39,88,797 have recovered as on November 27, 2021 at 4:06 am.

India

3,45,63,749 8,318Cases
1,07,0193,114Active
3,39,88,797 10,967Recovered
4,67,933 465Deaths
In India, there are 3,45,63,749 confirmed cases including 4,67,933 deaths. The number of active cases is 1,07,019 and 3,39,88,797 have recovered as on November 27, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

66,33,105

12,153 699

64,80,061 665

1,40,891 34

Kerala

51,24,618 4,677

50,109 2,343

50,35,384 6,632

39,125 388

Karnataka

29,94,963 402

6,640 119

29,50,130 277

38,193 6

Tamil Nadu

27,23,991 746

8,418 24

26,79,130 759

36,443 11

Andhra Pradesh

20,72,198 184

2,163 31

20,55,603 214

14,432 1

Uttar Pradesh

17,10,368 8

91 0

16,87,368 8

22,909

West Bengal

16,13,451 710

7,847 20

15,86,165 721

19,439 9

Delhi

14,40,807 23

301 8

14,15,411 31

25,095

Odisha

10,48,228 219

2,216 5

10,37,609 222

8,403 2

Chhattisgarh

10,06,706 33

319 7

9,92,794 26

13,593

Rajasthan

9,54,715 21

174 19

9,45,586 2

8,955

Gujarat

8,27,354 27

308 7

8,16,954 34

10,092

Madhya Pradesh

7,93,097 9

103 1

7,82,466 8

10,528

Haryana

7,71,643 21

158 2

7,61,431 19

10,054

Bihar

7,26,209 5

45 1

7,16,501 6

9,663

Telangana

6,75,319 171

3,534 3

6,67,798 167

3,987 1

Assam

6,16,312 175

2,791 44

6,07,435 219

6,086

Punjab

6,03,173 41

335 21

5,86,245 18

16,593 2

Jharkhand

3,49,196 12

109 0

3,43,947 12

5,140

Uttarakhand

3,44,169 13

144 13

3,36,618 26

7,407

Jammu And Kashmir

3,36,237 174

1,719 13

3,30,048 157

4,470 4

Himachal Pradesh

2,26,859 102

827 8

2,22,190 107

3,842 3

Goa

1,78,799 34

266 11

1,75,152 22

3,381 1

Mizoram

1,33,921 359

4,227 111

1,29,206 469

488 1

Puducherry

1,28,825 31

321 3

1,26,632 28

1,872

Manipur

1,25,098 28

674 13

1,22,456 39

1,968 2

Tripura

84,771 10

80 4

83,871 6

820

Meghalaya

84,394 16

335 4

82,591 20

1,468

Chandigarh

65,438 8

48 7

64,570 1

820

Arunachal Pradesh

55,260 2

33 1

54,947 3

280

Sikkim

32,207 9

119 6

31,685 15

403

Nagaland

32,096 4

136 5

31,264 9

696

Ladakh

21,467 32

243 8

21,011 24

213

Dadra And Nagar Haveli

10,683

1 0

10,678

4

Lakshadweep

10,394 11

29 11

10,314

51

Andaman And Nicobar Islands

7,678 1

3 0

7,546 1

129

Coronavirus Outbreak: Full CoverageTesting CentresFAQs
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Highlights From The 12-Hour Telethon

Leaving No One Behind

Mental Health

Environment

Join Us