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Covid Poses Higher Risk Of Rare Brain Conditions Than Vaccines: Study

There have been reports of rare neurological complications associated with SARS-CoV-2 infection and Oxford-AstraZeneca or Pfizer-BioNTech COVID-19 vaccines

Covid Poses Higher Risk Of Rare Brain Conditions Than Vaccines: Study
The study used what is known as a "self-controlled case series (SCCS)" design for analysis
Highlights
  • The study analysed healthcare records of over 32 million people in England
  • Risk of neurological complications within 28 days of a first dose: Study
  • Risk from Covid higher than risk from vaccine: Study

London: COVID-19 is more likely to cause very rare neurological conditions than vaccination with the AstraZeneca or Pfizer preventives, according to a study led by the University of Oxford in the UK. There have been reports of rare neurological complications associated with SARS-CoV-2 infection and Oxford-AstraZeneca or Pfizer-BioNTech COVID-19 vaccines. The study, published in the journal Nature Medicine on Monday, analysed anonymised healthcare records of over 32 million people across England.

Also Read: Centre Issues Guidelines To Prevent Surge In Covid Cases During Festivals

The researchers assessed the risk of developing neurological complications within 28 days of a first dose of either the AstraZeneca vaccine, known as Covishield in India, or Pfizer preventive, or within 28 days of testing positive for COVID-19.

They found an increased, but low, risk of the rare neurological conditions Guillain-Barre syndrome and Bel”s palsy following a first dose of the AstraZeneca vaccine and an increased but low risk of hemorrhagic stroke following a first dose of the Pfizer vaccine.

However, infection with COVID-19 was associated with a greater risk of developing neurological complications than receiving either vaccine, according to the researchers.

“This analysis provides important information about which neurological conditions could be linked with COVID-19 vaccination or infection,” said Professor Carol Coupland from the University of Nottingham, UK, one of the researchers involved in the study.

Overall, the findings from this study show that the risks of hospital admission with nervous system complications associated with COVID-19 infection are greater than the risks associated with COVID-19 vaccinations, Professor Coupland said.

The researchers found different risks for different types of neurological conditions depending on which vaccine people received.

However, these were substantially lower than the risks occurring in association with a positive COVID-19 PCR test.

For example, we estimate 145 excess cases of Guillain-Barre syndrome per 10 million people in the 28 days after a positive SARS-CoV-2 test, compared to 38 per 10 million for those who received the AstraZeneca vaccine, said Martina Patone from the University of Oxford, and co-lead author of the study.

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The researchers noted that the initial clinical trials of the vaccines were not large enough to be able to detect very rare adverse neurological events — those that happen in less than 1 person out of 10,000.

The latest study was able to achieve this by looking at the real-world data from over 32 million healthcare records in England, they said.

The study used what is known as a “self-controlled case series (SCCS)” design.

An SCSS compares how often adverse events — in this case neurological complications – happen in different set windows of time.

The authors noted several limitations to the study, including that only risks associated with the first vaccine dose were examined.

Data on outcomes following second doses was limited at the time of this study since the vaccination programme in the UK is still underway.

The researchers could also not distinguish between different types of Guillain-Barre syndrome due to the way healthcare records were coded.

Also Read: Young Children’s Diets Show No Improvement In Last Decade, Could Get Worse’ Under Covid: UNICEF

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol have been working towards a clean and healthy India since 2014 via Banega Swachh India initiative, which is helmed by Campaign Ambassador Amitabh Bachchan. The campaign aims to highlight the inter-dependency of humans and the environment, and of humans on one another with the focus on One Health, One Planet, One Future – Leaving No One Behind. It stresses on the need to take care of, and consider, everyone’s health in India – especially vulnerable communities – the LGBTQ populationindigenous people, India’s different tribes, ethnic and linguistic minorities, people with disabilities, migrants, geographically remote populations, gender and sexual minorities. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign will continue to raise awareness on the same along with focussing on the importance of nutrition and healthcare for women and children, fight malnutrition, mental wellbeing, self care, science and health, adolescent health & gender awareness. Along with the health of people, the campaign has realised the need to also take care of the health of the eco-system. Our environment is fragile due to human activity,  that is not only over-exploiting available resources, but also generating immense pollution as a result of using and extracting those resources. The imbalance has also led to immense biodiversity loss that has caused one of the biggest threats to human survival – climate change. It has now been described as a “code red for humanity.” The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene. Banega Swasth India will also be taking forward the dream of Swasth Bharat, the campaign feels that only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and the country can become a Swasth or healthy India.

World

26,06,51,261Cases
22,14,73,133Active
3,39,88,797Recovered
51,89,331Deaths
Coronavirus has spread to 196 countries. The total confirmed cases worldwide are 26,06,51,261 and 51,89,331 have died; 22,14,73,133 are active cases and 3,39,88,797 have recovered as on November 27, 2021 at 4:06 am.

India

3,45,63,749 8,318Cases
1,07,0193,114Active
3,39,88,797 10,967Recovered
4,67,933 465Deaths
In India, there are 3,45,63,749 confirmed cases including 4,67,933 deaths. The number of active cases is 1,07,019 and 3,39,88,797 have recovered as on November 27, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

66,33,105

12,153 699

64,80,061 665

1,40,891 34

Kerala

51,24,618 4,677

50,109 2,343

50,35,384 6,632

39,125 388

Karnataka

29,94,963 402

6,640 119

29,50,130 277

38,193 6

Tamil Nadu

27,23,991 746

8,418 24

26,79,130 759

36,443 11

Andhra Pradesh

20,72,198 184

2,163 31

20,55,603 214

14,432 1

Uttar Pradesh

17,10,368 8

91 0

16,87,368 8

22,909

West Bengal

16,13,451 710

7,847 20

15,86,165 721

19,439 9

Delhi

14,40,807 23

301 8

14,15,411 31

25,095

Odisha

10,48,228 219

2,216 5

10,37,609 222

8,403 2

Chhattisgarh

10,06,706 33

319 7

9,92,794 26

13,593

Rajasthan

9,54,715 21

174 19

9,45,586 2

8,955

Gujarat

8,27,354 27

308 7

8,16,954 34

10,092

Madhya Pradesh

7,93,097 9

103 1

7,82,466 8

10,528

Haryana

7,71,643 21

158 2

7,61,431 19

10,054

Bihar

7,26,209 5

45 1

7,16,501 6

9,663

Telangana

6,75,319 171

3,534 3

6,67,798 167

3,987 1

Assam

6,16,312 175

2,791 44

6,07,435 219

6,086

Punjab

6,03,173 41

335 21

5,86,245 18

16,593 2

Jharkhand

3,49,196 12

109 0

3,43,947 12

5,140

Uttarakhand

3,44,169 13

144 13

3,36,618 26

7,407

Jammu And Kashmir

3,36,237 174

1,719 13

3,30,048 157

4,470 4

Himachal Pradesh

2,26,859 102

827 8

2,22,190 107

3,842 3

Goa

1,78,799 34

266 11

1,75,152 22

3,381 1

Mizoram

1,33,921 359

4,227 111

1,29,206 469

488 1

Puducherry

1,28,825 31

321 3

1,26,632 28

1,872

Manipur

1,25,098 28

674 13

1,22,456 39

1,968 2

Tripura

84,771 10

80 4

83,871 6

820

Meghalaya

84,394 16

335 4

82,591 20

1,468

Chandigarh

65,438 8

48 7

64,570 1

820

Arunachal Pradesh

55,260 2

33 1

54,947 3

280

Sikkim

32,207 9

119 6

31,685 15

403

Nagaland

32,096 4

136 5

31,264 9

696

Ladakh

21,467 32

243 8

21,011 24

213

Dadra And Nagar Haveli

10,683

1 0

10,678

4

Lakshadweep

10,394 11

29 11

10,314

51

Andaman And Nicobar Islands

7,678 1

3 0

7,546 1

129

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