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Early BioNTech, Pfizer Data Suggests Boosters May Protect Against Omicron Infection

BioNTech and Pfizer have announced that a booster dose of their vaccine is effective in neutralising the new Omicron variant

Early BioNTech, Pfizer Data Suggests Boosters May Protect Against Omicron Infection
Pfizer and BioNTech suggest the use of a booster dose to neutralise Omicron
Highlights
  • Three doses of vaccination are required to restore protection: BioNTech
  • Current vaccines are still usable against the Omicron: Dr Walter
  • Data on Pfizer effectiveness against Omicron is encouraging:President Biden

BioNTech and Pfizer said on Wednesday a three-shot course of their COVID-19 vaccine was able to neutralise the new Omicron variant in a laboratory test, an early signal that booster shots could be key to protection against infection from the newly identified variant.The German and U.S. companies said two doses of their vaccine resulted in significantly lower neutralising antibodies but could still be protective against severe disease. The first line of defence, with two doses of vaccination, might be compromised and three doses of vaccination are required to restore protection, BioNTech Chief Medical Officer Ozlem Tuereci said at a press conference.

The companies also said they could deliver an upgraded vaccine targeted specifically at the Omicron variant in March 2022 if one is needed.

BioNTech and Pfizer are the first manufacturers of a COVID vaccine to issue an official update on the efficacy of their shot against Omicron.

In samples of blood taken around a month after the third shot the Omicron variant was neutralised about as effectively as two doses neutralised the original virus identified in China. The Omicron variant, first detected in southern Africa and Hong Kong last month, has triggered global alarm about another surge in infections. Cases have already been reported from Japan to the United States and across Europe.

Also Read: Omicron Could Be Milder Than Delta, Says WHO Chief

The new data from Pfizer on vaccine effectiveness against Omicron is encouraging, U.S. President Joe Biden tweeted on Wednesday. Anyone who is eligible and has not been boosted should go get a booster today.BioNTech CEO Ugur Sahin suggested that countries might consider shortening the time period between second and third doses of the vaccine to combat the new variant. He cited recent moves by countries including Britain to bring the third shot forward to three months after the second shot, from six months previously.

We believe this is the right way to go particularly if the Omicron is now spreading further, to enable a better level of protection in the winter season, Sahin said.Dr. Walter Orenstein, a professor at Vanderbilt and former director of the U.S. CDC’s immunization programs, said he found the data encouraging because it suggests that the current vaccines are still usable against the Omicron. We may not have to change the vaccine, he said. We may be able to get by with the current vaccine, at least for repression of severe disease.

Also Read: India’s Omicron Patient #2 – A Bengaluru Doctor Shares His Experience

OMICRON-SPECIFIC VACCINE

The World Health Organization classified Omicron on Nov. 26 as a “variant of concern” but said there was no evidence to support the need for new vaccines specifically designed to tackle the variant and its mutations.

Nevertheless, the companies said they would continue efforts to bring an Omicron-specific COVID-19 vaccine to market. Work started on the 25th of November. They said their planned production of 4 billion doses of the Comirnaty vaccine in 2022 was not expected to change if an adapted vaccine was required. BioNTech said that even if an adapted vaccine was available in March, it would not be broadly available for some time, noting that perhaps 25 to 75 million doses of the new vaccine would be ready at first. Pfizer scientist Kena Swanson said the company is considering also testing two doses of an Omicron-specific vaccine in currently unvaccinated people.

Pfizer and BioNTech’s findings are broadly in line with a preliminary study published by researchers at the Africa Health Research Institute in South Africa on Tuesday, which said Omicron could partially evade protection from two doses of the Pfizer/BioNTech vaccine and suggested a third shot might help fend off infection. Research on the new variant is still at an early stage. Laboratory analysis at University Hospital Frankfurt in Germany found the ability to mount an antibody response to Omicron in people who had three shots was up to 37 times lower than the response to Delta. Even so, two shots of the vaccine may still protect against severe disease, Pfizer and BioNTech said.

The vast majority of surface structures on the Omicron spike protein targeted by the T-cells, which typically emerge after vaccination, are not affected by Omicron’s mutations, they said. T-cells are the second pillar of an immune response, alongside antibodies, and are believed to prevent severe disease by attacking infected human cells.

Also Read: Explained: How Quickly Does Omicron Spread & What Is The Severity Of The Disease?

For their analysis, the two companies used a virus that was bio-engineered to have the hallmark mutations of Omicron, known as a pseudovirus, and blood was collected from subjects three weeks after a second vaccine dose or one month after a third.
There is no significant data yet on how vaccines from Moderna, Johnson & Johnson and other drugmakers hold up against the new variant but they are expected to release their own data within weeks.

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol have been working towards a clean and healthy India since 2014 via Banega Swachh India initiative, which is helmed by Campaign Ambassador Amitabh Bachchan. The campaign aims to highlight the inter-dependency of humans and the environment, and of humans on one another with the focus on One Health, One Planet, One Future – Leaving No One Behind. It stresses on the need to take care of, and consider, everyone’s health in India – especially vulnerable communities – the LGBTQ populationindigenous people, India’s different tribes, ethnic and linguistic minorities, people with disabilities, migrants, geographically remote populations, gender and sexual minorities. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign will continue to raise awareness on the same along with focussing on the importance of nutrition and healthcare for women and children, fight malnutrition, mental wellbeing, self care, science and health, adolescent health & gender awareness. Along with the health of people, the campaign has realised the need to also take care of the health of the eco-system. Our environment is fragile due to human activity,  that is not only over-exploiting available resources, but also generating immense pollution as a result of using and extracting those resources. The imbalance has also led to immense biodiversity loss that has caused one of the biggest threats to human survival – climate change. It has now been described as a “code red for humanity.” The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene. Banega Swasth India will also be taking forward the dream of Swasth Bharat, the campaign feels that only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and the country can become a Swasth or healthy India.

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