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Coronavirus Vaccine

Indian Institute of Science Professor, Collaborators Develop Potential Covid-19 Vaccine Candidate

Since the beginning of the Covid-19 pandemic, Raghavan Varadarajan, Professor at the Molecular Biophysics Unit (MBU), IISc, and collaborators have been working on developing a heat-tolerant vaccine that can offer protection against different strains of SARS-CoV-2- both current and future variants

IISc Professor, Collaborators Develop Potential Covid-19 Vaccine Candidate
In a study published in 'npj Vaccines', the scientists showed that their vaccine candidate is effective against all current strains of SARS-CoV-2

Bengaluru: An Indian Institute of Science (IISc) Professor and collaborators have designed a synthetic antigen that can be manufactured as a potential Covid-19 vaccine candidate. Since the beginning of the Covid-19 pandemic, Raghavan Varadarajan, Professor at the Molecular Biophysics Unit (MBU), IISc, and collaborators have been working on developing a heat-tolerant vaccine that can offer protection against different strains of SARS-CoV-2- both current and future variants.

In a study published in ‘npj Vaccines’, the scientists show that their vaccine candidate is effective against all current strains of SARS-CoV-2 and can be quickly adapted for future variants as well, according to the press release issued by the institution here on Wednesday (January 10).

Also Read: COVID-19 Updates: India Logs More than 600 Fresh Cases, Four Deaths

While current vaccines are proven to be effective against most SARS-CoV-2 strains, their efficacy has declined due to the virus’ rapid mutation, it said.

After analysing various proteins found in the virus, the researchers selected two parts of SARS-CoV-2’s spike protein — the S2 subunit and the Receptor Binding Domain (RBD) — for designing their vaccine candidate.

The S2 subunit is highly conserved and it mutates much less than the S1 subunit, which is the target of most current vaccines.

Scientists have also known that RBD can provoke a strong immune response in the host. Therefore, the team created a hybrid protein called RS2 by combining these two components, the release said.

The researchers used mammalian cell lines to study the expression of the hybrid protein. She added,

The protein showed very high levels of expression, and I [initially] thought that the experiment was not working properly,” said Nidhi Mittal, PhD student at MBU and first author of the study. This means that it can potentially be produced in large quantities.

The team then tested the effects of the protein in both mice and hamster models. They found that the hybrid protein triggered a strong immune response and provided better protection when compared to vaccines containing the whole spike protein.

The RS2 antigen can also be stored at room temperature for a month without the need for cold storage, unlike many vaccines on the market which require mandatory cold storage, it said, adding that this would make the distribution and storage of these vaccine candidates more economical.

Also Read: COVID-19 Updates: India Logs Over 400 Cases; Six Fatalities Reported From Three States

Mr Varadarajan explained that his team began working on the vaccine even before the effects of the pandemic became widespread in India. “At that time, the Bill and Melinda Gates Foundation provided us with funding and support,” he added.

Since 2000, Mr Varadarajan’s team has been working on designing several viral vaccines, including those against AIDS and influenza. They have leveraged this expertise to design their current RS2-based Covid-19 vaccine candidate in collaboration with the startup Mynvax, that was, until recently, incubated at IISc, the statement said.

According to the team, the vaccine candidate can be tailored to incorporate the RBD region of any new variant of SARS-CoV-2 that might emerge. Its high levels of expression and stability at room temperature can greatly reduce production and distribution costs, making it well suited for combating Covid-19.

Also Read: COVID-19 Updates: India Reports 605 New Cases, Four Deaths In The Last 24 Hours

(This story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol have been working towards a clean and healthy India since 2014 via the Banega Swachh India initiative, which in its Season 10 is helmed by Campaign Ambassador Ayushmann Khurrana. The campaign aims to highlight the inter-dependency of humans and the environment, and of humans on one another with the focus on One Health, One Planet, One Future – Leaving No One Behind. It stresses on the need to take care of, and consider, everyone’s health in India – especially vulnerable communities – the LGBTQ populationindigenous people, India’s different tribes, ethnic and linguistic minorities, people with disabilities, migrants, geographically remote populations, gender and sexual minorities. In a world post COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign will continue to raise awareness on the same along with focussing on the importance of nutrition and healthcare for women and children, fight malnutrition, mental well-being, self-care, science and health, adolescent health & gender awareness. Along with the health of people, the campaign has realised the need to also take care of the health of the eco-system. Our environment is fragile due to human activity, which is not only over-exploiting available resources, but also generating immense pollution as a result of using and extracting those resources. The imbalance has also led to immense biodiversity loss that has caused one of the biggest threats to human survival – climate change. It has now been described as a “code red for humanity.” The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene. Banega Swasth India will also be taking forward the dream of Swasth Bharat, the campaign feels that only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and the country can become a Swasth or healthy India.

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