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No Data Shows Need For Booster COVID-19 Vaccines Presently: Dr Gagandeep Kang

Fighting COVID-19: There is no cut-off level of antibodies which reliably predict protection at the individual levels. Antibodies are good, but not all of the immune response, said Dr Gagandeep Kang

No Data Shows Need For Booster COVID-19 Vaccines Presently: Dr Gagandeep Kang
Highlights
  • The third dose may help, it will not guarantee protection: Dr Kang
  • People with poor immune responses should get a third dose, said Dr Kang
  • Different vaccines need to be evaluated in sets of patients: Dr Kang

New Delhi: Speaking about when a booster dose should be administered, Dr Gagandeep Kang, professor at Christian Medical College Vellore on Tuesday (August 17), said some countries that have used inactivated, vectored vaccines or mRNA vaccines have begun to offer a booster dose to selected populations, like the elderly. Dr Kang added, “In India (and elsewhere), we do not have any data showing that anyone who has received two doses of vaccine needs booster vaccines at this time.”

Also Read: India Achieves Highest Ever COVID-19 Vaccination In A Single Day

Talking about Moderna and AstraZeneca she said,

Yes, the Moderna and AZ correlates of protection analysis shows that higher antibodies correlate with better protection, but there is no cut-off level of antibodies which reliably predict protection at the individual levels. Antibodies are good, but not all of the immune response.

According to Dr Kang, whether people will have more antibodies or be better protected with the booster dose is still not known.

It sounds obvious that more antibodies (abs) are better but we really don’t know whether people who push up abs with additional doses will be better protected than with the level they initially made. Or that when abs wane, we need to boost to maintain above some level, she said.

Also Read: Mixing And Matching Of Vaccines Will Help Overcome Shortage: Dr Gagandeep Kang

Further, she explained how people with a poor immune response should get a third dose,

Who needs the booster dose and when? At the moment, we do not know. But about the FDA recommendation; it is not for boosters as much as a recognition that people with poor immune responses should get a third dose as part of their primary series of immunizations, she said.

Talking of who should get an additional dose, Dr Kang said,

Remember that even though the 3rd dose may help, it will not guarantee protection, but the list is solid-organ transplant recipients, those getting active treatment for solid-tumours & haematologic malignancies, those with CAR T cell therapy or within 2 years of stem cell transplant, moderate or severe primary immunodeficiency (e.g., DiGeorge, Wiskott-Aldrich syndromes), advanced or untreated HIV infection or active treatment, with high-dose corticosteroids (i.e., >=20 mg prednisone or equivalent per day), alkylating agents, antimetabolites, transplant-related immunosuppressive drugs, cancer chemotherapeutic agents classified as severely immunosuppressive, tumour necrosis factor (TNF) blockers, and other biologic agents that are immunosuppressive or immunomodulatory.

Also Read: WHO Calls For ‘Moratorium’ On COVID-19 Vaccine Boosters Until At Least September-End To Address Vaccination Disparity

Dr Kang also said that the third dose isn’t currently recommended in many countries but should be considered, and added,

Different vaccines need to be evaluated in sets of patients to see which vx (or combinations) offer the most benefit to these groups of vulnerable people. Again, not boosters at this time.

According to the latest updates, Pfizer Inc and its German partner BioNTech SE have submitted the initial data from an early-stage trial toward seeking authorization of a booster dose of their COVID-19 vaccine. Earlier, Dr V K Paul, Member (Health) on booster dose had said,

We are watching the science for the need for such booster dose. World Health Organization has called for a moratorium. Booster dose and whether there is a need for it and who will need it is a very relevant issue. Let’s say it’s a work in progress in fact a work in progress.

Also Read: 4 More Indian Pharma Firms Expected To Start COVID Vaccine Production By October-November: Union Health Minister

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

24,00,62,413Cases
20,17,73,183Active
3,33,99,961Recovered
48,89,269Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 24,00,62,413 and 48,89,269 have died; 20,17,73,183 are active cases and 3,33,99,961 have recovered as on October 16, 2021 at 4:08 am.

India

3,40,53,573 15,981Cases
2,01,6322,046Active
3,33,99,961 17,861Recovered
4,51,980 166Deaths
In India, there are 3,40,53,573 confirmed cases including 4,51,980 deaths. The number of active cases is 2,01,632 and 3,33,99,961 have recovered as on October 16, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,88,429 2,149

33,379 222

64,15,316 1,898

1,39,734 29

Kerala

48,38,811 8,867

95,349 1,072

47,16,728 9,872

26,734 67

Karnataka

29,82,869 470

9,700 93

29,35,238 368

37,931 9

Tamil Nadu

26,84,641 1,245

15,238 213

26,33,534 1,442

35,869 16

Andhra Pradesh

20,59,708 586

6,453 135

20,38,960 712

14,295 9

Uttar Pradesh

17,10,014 6

133 2

16,86,984 8

22,897

West Bengal

15,79,463 451

7,513 63

15,52,997 506

18,953 8

Delhi

14,39,337 26

327 10

14,13,921 36

25,089

Odisha

10,34,276 467

4,817 73

10,21,180 535

8,279 5

Chhattisgarh

10,05,624 10

197 6

9,91,857 16

13,570

Rajasthan

9,54,383 1

40 2

9,45,389 3

8,954

Gujarat

8,26,258 14

212 3

8,15,960 17

10,086

Madhya Pradesh

7,92,675 6

106 5

7,82,046 11

10,523

Haryana

7,71,049 14

116 11

7,60,884 3

10,049

Bihar

7,26,021 5

46 4

7,16,314 1

9,661

Telangana

6,68,722 104

4,056 115

6,60,730 218

3,936 1

Assam

6,05,944 97

3,458 188

5,96,547 284

5,939 1

Punjab

6,01,992 21

228 6

5,85,224 25

16,540 2

Jharkhand

3,48,415 9

130 0

3,43,150 9

5,135

Uttarakhand

3,43,739 10

179 4

3,36,163 6

7,397

Jammu And Kashmir

3,30,885 51

895 40

3,25,564 91

4,426

Himachal Pradesh

2,21,203 90

1,361 26

2,16,125 114

3,717 2

Goa

1,77,410 54

648 31

1,73,423 81

3,339 4

Puducherry

1,27,296 37

611 36

1,24,836 73

1,849

Manipur

1,22,545 113

1,444 0

1,19,208 109

1,893 4

Mizoram

1,11,651 932

13,316 285

97,955 1,211

380 6

Tripura

84,299 4

102 8

83,381 12

816

Meghalaya

82,815 81

893 1

80,490 79

1,432 1

Chandigarh

65,297 2

30 2

64,447 4

820

Arunachal Pradesh

54,964 6

183 19

54,501 25

280

Sikkim

31,739 17

189 35

31,159 51

391 1

Nagaland

31,547 31

228 2

30,645 32

674 1

Ladakh

20,871 4

42 2

20,621 6

208

Dadra And Nagar Haveli

10,675

3 0

10,668

4

Lakshadweep

10,365

1 1

10,313 1

51

Andaman And Nicobar Islands

7,641 1

9 1

7,503 2

129

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