Connect with us

Coronavirus Outbreak

WHO Recommends Antibody Treatment For Critical Covid Patients

COVID-19: The WHO Guideline Development Group (GDG) panel recommends treatment combining casirivimab and imdevimab for two specific groups of patients with COVID-19

WHO Recommends Antibody Treatment For Critical Covid Patients

New Delhi: COVID-19 patients at high risk of hospitalisation or those with severe disease should be given a combination of two antibody treatments, according to latest World Health Organisation guidelines published in The BMJ today. The WHO Guideline Development Group (GDG) panel recommends treatment combining casirivimab and imdevimab for two specific groups of patients with COVID-19.

Also Read: Keep Strict Vigil To Prevent The Spread Of COVID-19 During Festivals: Union Health Secretary To States, UTs

The first are patients with non-severe COVID-19 who are at highest risk of hospitalisation and the second are those with severe or critical COVID-19 who are seronegative, meaning they have not mounted their own antibody response to COVID-19.

The first recommendation is based on new evidence from three trials that have not yet been peer reviewed.

The trial show that casirivimab and imdevimab may reduce the risk of hospitalisation and duration of symptoms in those at highest risk of severe disease, such as unvaccinated, older, or immunosuppressed patients.

The second recommendation is based on data from another trial which shows that the two antibodies probably reduce deaths and the need for mechanical ventilation in seronegative patients.

This study showed that treatment with Casirivimab and imdevimab led 49 fewer deaths per 1,000 in the severely ill and 87 fewer deaths in the critically ill patients.

For all other COVID-19 patients, any benefits of this antibody treatment are unlikely to be meaningful, the panel noted.

Casirivimab and imdevimab are monoclonal antibodies that when used together bind to theS-CoV-2 spike protein, neutralising the virus’s ability to infect cells. The spike protein helps the virus to bind and infect the human cells.

The panel acknowledged several cost and resource implications associated with this treatment, which may make access to low and middle income countries challenging.

Also Read: Union Health Ministry Issues Guidelines For COVID Vaccination At Home For People With Special Needs

For example, rapid serological tests will be needed to identify eligible patients who are severely ill, treatment must be given intravenously using specialist equipment, and patients should be monitored for allergic reactions.

They also recognise the possibility that new variants may emerge in which casirivimab and imdevimab antibodies may have reduced effect.

However, the panel says given the demonstrated benefits for patients, “the recommendations should provide a stimulus to engage all possible mechanisms to improve global access to the intervention and associated testing.”

The latest guidance adds to previous recommendations for the use of interleukin-6 receptor blockers and systemic corticosteroids for patients with severe or critical COVID-19.

The panel also recommends against the use of ivermectin and hydroxychloroquine in patients with COVID-19 regardless of disease severity.

Also Read: Close-Knit Society, Delta Variant, Ignoring Covid-Appropriate Behaviour Behind Rising Cases In Mizoram: Reports

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol have been working towards a clean and healthy India since 2014 via Banega Swachh India initiative, which is helmed by Campaign Ambassador Amitabh Bachchan. The campaign aims to highlight the inter-dependency of humans and the environment, and of humans on one another with the focus on One Health, One Planet, One Future – Leaving No One Behind. It stresses on the need to take care of, and consider, everyone’s health in India – especially vulnerable communities – the LGBTQ populationindigenous people, India’s different tribes, ethnic and linguistic minorities, people with disabilities, migrants, geographically remote populations, gender and sexual minorities. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign will continue to raise awareness on the same along with focussing on the importance of nutrition and healthcare for women and children, fight malnutrition, mental wellbeing, self care, science and health, adolescent health & gender awareness. Along with the health of people, the campaign has realised the need to also take care of the health of the eco-system. Our environment is fragile due to human activity,  that is not only over-exploiting available resources, but also generating immense pollution as a result of using and extracting those resources. The imbalance has also led to immense biodiversity loss that has caused one of the biggest threats to human survival – climate change. It has now been described as a “code red for humanity.” The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene. Banega Swasth India will also be taking forward the dream of Swasth Bharat, the campaign feels that only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and the country can become a Swasth or healthy India.

 

World

24,06,78,961Cases
20,23,40,977Active
3,34,39,331Recovered
48,98,653Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 24,06,78,961 and 48,98,653 have died; 20,23,40,977 are active cases and 3,34,39,331 have recovered as on October 18, 2021 at 4:17 am.

India

3,40,81,315 13,596Cases
1,89,6946,152Active
3,34,39,331 19,582Recovered
4,52,290 166Deaths
In India, there are 3,40,81,315 confirmed cases including 4,52,290 deaths. The number of active cases is 1,89,694 and 3,34,39,331 have recovered as on October 18, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,91,697 1,715

32,230 994

64,19,678 2,680

1,39,789 29

Kerala

48,54,321 7,555

88,186 3,292

47,39,270 10,773

26,865 74

Karnataka

29,83,459 326

9,479 58

29,36,039 380

37,941 4

Tamil Nadu

26,87,092 1,218

14,814 208

26,36,379 1,411

35,899 15

Andhra Pradesh

20,60,472 432

6,034 159

20,40,131 586

14,307 5

Uttar Pradesh

17,10,028 9

119 10

16,87,011 19

22,898

West Bengal

15,80,530 624

7,421 24

15,54,132 634

18,977 14

Delhi

14,39,390 32

320 6

14,13,981 38

25,089

Odisha

10,35,077 443

4,542 68

10,22,250 508

8,285 3

Chhattisgarh

10,05,654 16

183 2

9,91,901 14

13,570

Rajasthan

9,54,390 2

42 2

9,45,394 4

8,954

Gujarat

8,26,290 10

207 6

8,15,997 16

10,086

Madhya Pradesh

7,92,684 5

84 12

7,82,077 17

10,523

Haryana

7,71,076 15

123 9

7,60,904 6

10,049

Bihar

7,26,026 5

48 4

7,16,317 1

9,661

Telangana

6,68,955 122

3,924 55

6,61,093 176

3,938 1

Assam

6,06,468 205

3,436 46

5,97,082 245

5,950 6

Punjab

6,02,035 27

227 8

5,85,264 16

16,544 3

Jharkhand

3,48,430 7

122 1

3,43,173 8

5,135

Uttarakhand

3,43,756 9

178 1

3,36,181 8

7,397

Jammu And Kashmir

3,31,062 95

843 12

3,25,793 107

4,426

Himachal Pradesh

2,21,437 131

1,303 5

2,16,414 125

3,720 1

Goa

1,77,522 60

604 6

1,73,572 62

3,346 4

Puducherry

1,27,396 52

585 13

1,24,961 64

1,850 1

Manipur

1,22,737 104

1,422 0

1,19,418 102

1,897 2

Mizoram

1,12,848 249

11,633 1,143

1,00,829 1,389

386 3

Tripura

84,321 16

104 4

83,401 12

816

Meghalaya

82,953 55

845 32

80,673 86

1,435 1

Chandigarh

65,302 3

25 3

64,457 6

820

Arunachal Pradesh

54,987 7

140 30

54,567 37

280

Sikkim

31,749 4

174 8

31,184 12

391

Nagaland

31,611 40

248 12

30,689 28

674

Ladakh

20,878 2

36 10

20,634 12

208

Dadra And Nagar Haveli

10,676 1

4 1

10,668

4

Lakshadweep

10,365

0 0

10,314

51

Andaman And Nicobar Islands

7,641

9 0

7,503

129

Coronavirus Outbreak: Full CoverageTesting CentresFAQs

Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Highlights From The 12-Hour Telethon

Leaving No One Behind

Mental Health

Environment

Join Us