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Monkeypox Vaccine Expected To Induce Strong Immune Response: Study

According to the study published in the journal Viruses, specific vaccinia virus (VACV)-based vaccines have demonstrated high efficacy against monkeypox viruses in the past

Monkeypox Vaccine Expected To Induce Strong Immune Response: Study
The data used for the study supported the use of vaccines being recommended globally for combating Monkeypox
  • Over 52,000 Monkeypox cases reported in over 90 countries & regions: Study
  • Vaccinia virus based vaccines have high efficacy against Monkeypox: Study
  • WHO recommends primary preventive vaccination against new monkeypox virus

Melbourne: The recommended vaccinia virus (VACV)-based vaccines will mount a robust immune response against the monkeypox virus observed in the current outbreak, according to a study. Vaccinia virus is a large, complex, enveloped virus belonging to the poxvirus family. Since the new virus was first observed in early May, over 52,000 cases have been confirmed in more than 90 countries and regions, the researchers said.

The team undertook genomic research to find out if the genetic mutations observed in monkeypox virus observed in the current outbreak (MPXV-2022) may affect vaccine-induced immune responses against the disease.

Specific VACV-based vaccines have demonstrated high efficacy against monkeypox viruses in the past and are considered an important outbreak control measure. However, given this is a novel monkeypox virus, we still lack scientific data on how well human immune responses triggered by VACV-based vaccines will recognise MPXV-2022 and provide protection against disease, said Matthew McKay, from the University of Melbourne, Australia.

Also Read: 3 Of 5 Monkeypox Cases From Delhi Reveal Heterosexual Contact: ICMR Study

The study, published recently in the journal Viruses, evaluated the genetic similarities and differences between VACV and MPXV-2022, specifically within the protein regions that are targeted by vaccine-induced neutralising antibodies or T cells.

While we identified a small number of distinct mutations in MPXV-2022, our study more broadly demonstrates that VACV and MPXV-2022 are highly genetically similar in the regions targeted by the immune system through vaccination, Mr. McKay explained.

Also Read: ICMR Plans Sero-Survey Among Contacts Of Monkeypox Patients

Professor Ahmed Abdul Quadeer, from Hong Kong University of Science and Technology (HKUST), said,

Based on our analysis, we anticipate that the immune responses generated by VACV-based vaccines would continue to do a good job of recognising and responding to MPXV-2022, as was the case for monkeypox viruses in the past.Our data lends further support to the use of vaccines being recommended globally for combating MPXV-2022.

The World Health Organization has recommended primary preventive vaccination against the new monkeypox virus, which is also known as pre-exposure prophylaxis, for individuals at high risk of exposure.

While bringing together sequencing and immunological data provides evidence to anticipate a strong immune response, clinical studies are required to determine the exact efficacy of these vaccines against MPXV-2022,” Mr. McKay added.

Also Read: Tomato Flu vs Monkeypox: Here Is What Experts Have To Say

(This story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol have been working towards a clean and healthy India since 2014 via the Banega Swachh India initiative, which is helmed by Campaign Ambassador Amitabh Bachchan. The campaign aims to highlight the inter-dependency of humans and the environment, and of humans on one another with the focus on One Health, One Planet, One Future – Leaving No One Behind. It stresses on the need to take care of, and consider, everyone’s health in India – especially vulnerable communities – the LGBTQ population, indigenous people, India’s different tribes, ethnic and linguistic minorities, people with disabilities, migrants, geographically remote populations, gender and sexual minorities. In wake of the current COVID-19 pandemic, the need for WASH (Water, Sanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign will continue to raise awareness on the same along with focussing on the importance of nutrition and healthcare for women and children, fight malnutrition, mental wellbeing, self care, science and health, adolescent health & gender awareness. Along with the health of people, the campaign has realised the need to also take care of the health of the eco-system. Our environment is fragile due to human activity, which is not only over-exploiting available resources, but also generating immense pollution as a result of using and extracting those resources. The imbalance has also led to immense biodiversity loss that has caused one of the biggest threats to human survival – climate change. It has now been described as a “code red for humanity.” The campaign will continue to cover issues like air pollution, waste management, plastic ban, manual scavenging and sanitation workers and menstrual hygiene. Banega Swasth India will also be taking forward the dream of Swasth Bharat, the campaign feels that only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and the country can become a Swasth or healthy India.


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