Connect with us

Coronavirus Outbreak

Signs Of Brain Inflammation Found In People Who Died Of COVID-19: Study

According to experts, it is likely that many COVID-19 patients, especially those reporting or exhibiting neurological problems or those who are hospitalised, have neuroinflammatory markers that trigger inflammatory responses

Signs Of Brain Inflammation Found In People Who Died Of COVID-19: Study

Boston: Scientists have found signs of inflammation and neurodegeneration in the brains of individuals who died of COVID-19, similar to what is observed in people who die of conditions such as Alzheimer’s and Parkinson’s disease. The findings by researchers at the Stanford School of Medicine, US, and Saarland University in Germany may help explain why many COVID-19 patients report neurological problems. These complaints increase with more severe cases of COVID-19, and can persist as an aspect of “long COVID,” a long-lasting disorder that sometimes arises following infection with SARS-CoV-2, the virus that causes COVID-19.

Also Read: How Has COVID-19 And Lockdown Affected Children, Pregnant Women And Lactating Mothers?

About one-third of individuals hospitalised for COVID-19 report symptoms of fuzzy thinking, forgetfulness, difficulty concentrating and depression, said Tony Wyss-Coray, a professor at Stanford. The researchers could not find any signs of SARS-CoV-2 in brain tissue they obtained from eight individuals who died of the disease. Brain samples from 14 people who died of other causes were used as controls for the study.

The brains of patients who died from severe COVID-19 showed profound molecular markers of inflammation, even though those patients didn’t have any reported clinical signs of neurological impairment, said Mr Wyss-Coray.

The blood-brain barrier consists in part of blood-vessel cells that are tightly stitched together and blob-like abutments created by brain cells’ projections squishing up against the vessels. It has until recently been thought to be exquisitely selective in granting access to cells and molecules produced outside the brain. However, previous work by Mr Wyss-Coray’s group and others has shown that bloodborne factors outside the brain can signal through the blood-brain barrier to ignite inflammatory responses inside the brain.

Also Read: Is Second Wave Of COVID-19 Over? Positivity Rate Below 5 Per Cent For 15 Days, But Experts Say End Still Far

The latest study, published in the journal Nature, found that activation levels of hundreds of genes in all major cell types in the brain differed in the COVID-19 patients’ brains versus the control group’s brains. Many of these genes are associated with inflammatory processes, the researchers said.

There also were signs of distress in neurons in the cerebral cortex, the brain region that plays a key role in decision-making, memory and mathematical reasoning. These neurons, which are mostly of two types — excitatory and inhibitory — form complex logic circuits that perform those higher brain functions.

The outermost layers of the cerebral cortex of patients who died of COVID-19 showed molecular changes suggesting suppressed signalling by excitatory neurons, along with heightened signalling by inhibitory neurons, which act like brakes on excitatory neurons. This kind of signalling imbalance has been associated with cognitive deficits and neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease, the researchers said.

Viral infection appears to trigger inflammatory responses throughout the body that may cause inflammatory signalling across the blood-brain barrier, which in turn could trip off neuroinflammation in the brain. It is likely that many COVID-19 patients, especially those reporting or exhibiting neurological problems or those who are hospitalised, have these neuroinflammatory markers we saw in the people we looked at who had died from the disease, Mr Wyss-Coray said.

Also Read: ‘Lifeline’ Tech Helps Poor Rural Women Get Through India’s COVID-19 Crisis

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

22,70,55,138Cases
18,97,86,461Active
3,25,98,424Recovered
46,70,253Deaths
Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 22,70,55,138 and 46,70,253 have died; 18,97,86,461 are active cases and 3,25,98,424 have recovered as on September 17, 2021 at 5:36 am.

India

3,33,81,728 34,403Cases
3,39,0563,867Active
3,25,98,424 37,950Recovered
4,44,248 320Deaths
In India, there are 3,33,81,728 confirmed cases including 4,44,248 deaths. The number of active cases is 3,39,056 and 3,25,98,424 have recovered as on September 17, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,11,525 3,595

52,893 310

63,20,310 3,240

1,38,322 45

Kerala

44,46,228 22,182

1,86,754 4,559

42,36,309 26,563

23,165 178

Karnataka

29,65,191 1,108

16,202 282

29,11,434 808

37,555 18

Tamil Nadu

26,40,361 1,693

16,756 120

25,88,334 1,548

35,271 25

Andhra Pradesh

20,34,786 1,367

14,708 105

20,06,034 1,248

14,044 14

Uttar Pradesh

17,09,628 23

193 11

16,86,549 11

22,886 1

West Bengal

15,59,567 707

8,025 25

15,32,922 725

18,620 7

Delhi

14,38,373 28

409 5

14,12,880 22

25,084 1

Odisha

10,18,298 580

5,335 105

10,04,845 681

8,118 4

Chhattisgarh

10,04,988 31

352 2

9,91,077 29

13,559

Rajasthan

9,54,230 4

103 1

9,45,173 5

8,954

Gujarat

8,25,677 22

149 0

8,15,446 22

10,082

Madhya Pradesh

7,92,374 7

119 5

7,81,738 12

10,517

Haryana

7,70,697 9

327 8

7,60,562 17

9,808

Bihar

7,25,864 12

72 6

7,16,134 6

9,658

Telangana

6,62,785 259

5,282 43

6,53,603 301

3,900 1

Punjab

6,01,180 30

314 11

5,84,399 38

16,467 3

Assam

5,97,074 468

5,381 15

5,85,914 479

5,779 4

Jharkhand

3,48,102 6

102 8

3,42,867 14

5,133

Uttarakhand

3,43,330 20

284 12

3,35,657 32

7,389

Jammu And Kashmir

3,27,466 170

1,421 72

3,21,630 98

4,415

Himachal Pradesh

2,16,430 127

1,568 82

2,11,215 206

3,647 3

Goa

1,75,183 95

699 1

1,71,195 96

3,289

Puducherry

1,25,170 107

963 63

1,22,380 42

1,827 2

Manipur

1,17,913 216

2,614 7

1,13,478 219

1,821 4

Tripura

83,787 31

427 26

82,553 56

807 1

Meghalaya

78,958 229

1,804 140

75,784 86

1,370 3

Mizoram

76,591 1,121

13,888 85

62,449 1,202

254 4

Chandigarh

65,168 4

31 2

64,319 2

818

Arunachal Pradesh

53,990 47

536 9

53,183 56

271

Sikkim

30,802 64

775 28

29,648 36

379

Nagaland

30,763 32

505 14

29,610 44

648 2

Ladakh

20,631 6

41 1

20,383 5

207

Dadra And Nagar Haveli

10,670

5 0

10,661

4

Lakshadweep

10,353

4 0

10,298

51

Andaman And Nicobar Islands

7,595 3

15 2

7,451 1

129

Coronavirus Outbreak: Full CoverageTesting CentresFAQs

Leaving No One Behind

Mental Health

Environment

Join Us