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COVID-19 Vaccines Effective At Reducing Severe Illness, Hospitalisation: Lancet Study

According to a large-scale study published in The Lancet Infectious Diseases journal, the odds of experiencing long COVID — illness lasting 28 days or more after a positive test — were reduced to half for people who received two vaccines doses

COVID-19 Vaccines Effective At Reducing Severe Illness, Hospitalisation: Lancet Study
Highlights
  • The researchers used self-reported data from the UK COVID Symptom Study
  • The data included over 1.2 million adults who have got one dose of vaccine
  • Fewer than 0.5% reported a breakthrough infection after first dose: Study

London: People infected with the SARS-CoV-2 virus after receiving one or two COVID-19 vaccine doses have significantly lower chance of severe disease or hospitalisation than unvaccinated individuals, according to a large-scale study published in The Lancet Infectious Diseases journal on Tuesday. Researchers also found that the odds of experiencing long COVID — illness lasting 28 days or more after a positive test — were reduced to half for people who received two vaccines doses. People most vulnerable to a breakthrough infection after their first vaccine dose included frail older adults, 60 years and older, and those living with underlying conditions such as obesity, heart disease, kidney disease, and lung disease, they said.

Also Read: Protection From Pfizer And AstraZeneca’s COVID-19 Vaccine Wanes Within Six Months: UK Study

The study found that in all age groups, people living in deprived areas, such as densely populated urban settings, were more likely to experience a breakthrough infection. These factors were most significantly associated with a post-immunisation infection after receiving the first vaccine dose and before receiving a second dose, it found.

We are at a critical point in the pandemic as we see cases rising worldwide due to the Delta variant. Breakthrough infections are expected and don’t diminish the fact that these vaccines are doing exactly what they were designed to do — save lives and prevent serious illness, said study co-lead author Claire Steves of King’s College London, UK.

“Other research has shown a mortality rate as high as 27 per cent for hospitalised COVID-19 patients. We can greatly reduce that number by keeping people out of the hospital in the first place through vaccination,” Claire Steves said.

The study highlights the crucial role vaccines play in larger efforts to prevent COVID-19 infections, which should still include other personal protective measures such as mask-wearing, frequent testing, and social distancing.

Also Read: Pfizer Jab Side Effects In 12–15-Year-Olds At High Risk Of COVID-19 Complications, Mild To Moderate: Study

The researchers used self-reported data from the UK COVID Symptom Study through the ZOE app from December 8, 2020 through July 4, 2021. They found that of more than 1.2 million adults who received at least one dose of either the Pfizer-BioNTech, Oxford-AstraZeneca, or Moderna vaccine, fewer than 0.5 per cent reported a breakthrough infection over 14 days after their first dose.

Among adults who received two vaccine doses, fewer than 0.2 per cent experienced a breakthrough infection more than seven days after their second dose, the researchers said. Among those who did experience a breakthrough infection, the odds of being asymptomatic increased by 63 per cent after one vaccine dose and by 94 per cent after the second dose, they said.

Also Read: Study Shows Downside Of Not Receiving Second Shot Of COVID-19 Vaccine

Researchers also found that the odds of hospitalisation were reduced by approximately 70 per cent after one or two doses, and that the odds of experiencing severe disease were lessened by about one-third. Also, the odds of long COVID were reduced by 50 per cent after two doses, they said. Severe disease was defined as having five or more symptoms in the first week of illness. For those who did experience symptoms after either one or two vaccine doses, such as fatigue, cough, fever, and loss of taste and smell, almost all symptoms were reported less frequently than in unvaccinated people, according to the study. In frail adults over the age of 60 years, the researchers said, the odds of a breakthrough infection after one vaccine dose were almost doubled, compared to healthy older adults.

The authors acknowledged some limitations of the study. The research used self-reported data and therefore the comorbidities, test results, and vaccination status could be inaccurate or incomplete, and individuals living in more deprived areas could be underrepresented. These findings may not apply to all timepoints post-vaccination, to settings with different proportions of SARS-CoV-2 variants, or to countries with different vaccination schedules, the researchers added.

Also Read: New Variant (C.1.2) Of Coronavirus May Be More Infectious, Evade Vaccines: Study

(This story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

26,06,51,261Cases
22,14,73,133Active
3,39,88,797Recovered
51,89,331Deaths
Coronavirus has spread to 196 countries. The total confirmed cases worldwide are 26,06,51,261 and 51,89,331 have died; 22,14,73,133 are active cases and 3,39,88,797 have recovered as on November 27, 2021 at 4:06 am.

India

3,45,63,749 8,318Cases
1,07,0193,114Active
3,39,88,797 10,967Recovered
4,67,933 465Deaths
In India, there are 3,45,63,749 confirmed cases including 4,67,933 deaths. The number of active cases is 1,07,019 and 3,39,88,797 have recovered as on November 27, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

66,33,105

12,153 699

64,80,061 665

1,40,891 34

Kerala

51,24,618 4,677

50,109 2,343

50,35,384 6,632

39,125 388

Karnataka

29,94,963 402

6,640 119

29,50,130 277

38,193 6

Tamil Nadu

27,23,991 746

8,418 24

26,79,130 759

36,443 11

Andhra Pradesh

20,72,198 184

2,163 31

20,55,603 214

14,432 1

Uttar Pradesh

17,10,368 8

91 0

16,87,368 8

22,909

West Bengal

16,13,451 710

7,847 20

15,86,165 721

19,439 9

Delhi

14,40,807 23

301 8

14,15,411 31

25,095

Odisha

10,48,228 219

2,216 5

10,37,609 222

8,403 2

Chhattisgarh

10,06,706 33

319 7

9,92,794 26

13,593

Rajasthan

9,54,715 21

174 19

9,45,586 2

8,955

Gujarat

8,27,354 27

308 7

8,16,954 34

10,092

Madhya Pradesh

7,93,097 9

103 1

7,82,466 8

10,528

Haryana

7,71,643 21

158 2

7,61,431 19

10,054

Bihar

7,26,209 5

45 1

7,16,501 6

9,663

Telangana

6,75,319 171

3,534 3

6,67,798 167

3,987 1

Assam

6,16,312 175

2,791 44

6,07,435 219

6,086

Punjab

6,03,173 41

335 21

5,86,245 18

16,593 2

Jharkhand

3,49,196 12

109 0

3,43,947 12

5,140

Uttarakhand

3,44,169 13

144 13

3,36,618 26

7,407

Jammu And Kashmir

3,36,237 174

1,719 13

3,30,048 157

4,470 4

Himachal Pradesh

2,26,859 102

827 8

2,22,190 107

3,842 3

Goa

1,78,799 34

266 11

1,75,152 22

3,381 1

Mizoram

1,33,921 359

4,227 111

1,29,206 469

488 1

Puducherry

1,28,825 31

321 3

1,26,632 28

1,872

Manipur

1,25,098 28

674 13

1,22,456 39

1,968 2

Tripura

84,771 10

80 4

83,871 6

820

Meghalaya

84,394 16

335 4

82,591 20

1,468

Chandigarh

65,438 8

48 7

64,570 1

820

Arunachal Pradesh

55,260 2

33 1

54,947 3

280

Sikkim

32,207 9

119 6

31,685 15

403

Nagaland

32,096 4

136 5

31,264 9

696

Ladakh

21,467 32

243 8

21,011 24

213

Dadra And Nagar Haveli

10,683

1 0

10,678

4

Lakshadweep

10,394 11

29 11

10,314

51

Andaman And Nicobar Islands

7,678 1

3 0

7,546 1

129

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